A5009629015- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Radiation Dose and Imaging
- Gallbladder and Bile Duct Disorders
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury Research
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Lymphatic System and Diseases
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and Treatment of Venous Diseases
- Cardiac Arrest and Resuscitation
- Autopsy Techniques and Outcomes
- Burn Injury Management and Outcomes
- Ultrasound in Clinical Applications
- Wound Healing and Treatments
- Child Abuse and Related Trauma
- Neonatal and fetal brain pathology
- Pressure Ulcer Prevention and Management
- Pharmacological Effects and Toxicity Studies
- Traumatic Ocular and Foreign Body Injuries
- Esophageal and GI Pathology
- Epilepsy research and treatment
Queensland Children’s Hospital
2016-2025
The University of Queensland
2014-2025
Hammersmith Hospital
2013-2025
Royal Children's Hospital
2014-2024
Murdoch Children's Research Institute
2023-2024
Queensland University of Technology
2024
McPherson College
2024
Harley-Davidson (United States)
2024
Dr. John T. Macdonald Foundation
2024
East Sussex Healthcare NHS Trust
2021-2024
Objectives: Research in critically ill children poses challenges acquiring prospective informed consent. International ethical guidelines generally have provisions to perform research without prior consent (RWPC) circumstances where is not feasible, but there a paucity of data regarding the community acceptance this process. The objectives current study were explore attitudes and experiences parents enrolled into trials determine understanding acceptability RWPC involved. Design: Qualitative...
Background Sepsis is defined as dysregulated host response to infection that leads life-threatening organ dysfunction. Biomarkers characterising the in sepsis are lacking. We aimed develop gene expression signatures predict dysfunction children with bacterial or viral infection. Methods This cohort study was done emergency departments and intensive care units of four hospitals Queensland, Australia, recruited aged 1 month 17 years who, upon admission, underwent a diagnostic test, including...
OBJECTIVES: In children with septic shock, guidelines recommend resuscitation 40–60 mL/kg of fluid boluses, yet there is a lack evidence to support this practice. We aimed determine the feasibility randomized trial comparing early adrenaline infusion standard in shock. DESIGN: Open-label parallel controlled, multicenter pilot study. The primary end point was feasibility; exploratory clinical endpoint survival free organ dysfunction by 28 days. SETTING: Four pediatric Emergency Departments...
Head injuries in children are responsible for a large number of emergency department visits. Failure to identify clinically significant intracranial injury timely fashion may result long term neurodisability and death. Whilst cranial computed tomography (CT) provides rapid definitive identification injuries, it is resource intensive associated with radiation induced cancer. Evidence based head clinical decision rules have been derived aid physicians identifying patients at risk having...
Abstract Objective Children admitted to hospital commonly require peripheral intravenous catheters ( PIVCs ) for treatment. This study sought address a gap in the literature about current practice securement and dressing of paediatric acute care, ascertain duration failure these devices. Methods A prospective cohort conducted at R oyal C hildren's H ospital Q ueensland, ustralia. All patients aged 0–15 years, who presented ED between 16 J uly O ctober 2012, had PIVC inserted prior emergent...
Sepsis is a life-threatening disease caused by dysregulated host response to infection, resulting in 11 million deaths globally each year. Vascular endothelial cell dysfunction results the loss of barrier integrity, which contributes sepsis-induced multiple organ failure and mortality. Erythropoietin-producing hepatocellular carcinoma (Eph) receptors their ephrin ligands play key role vascular disruption but are currently not therapeutic target sepsis. Using cecal ligation puncture (CLP)...
OBJECTIVES: Vitamin C and thiamin have been trialed as adjunctive therapies in adults with septic shock but their role critically ill children is unclear. We assessed serum levels of vitamin evaluated for sepsis. DESIGN: Single-center prospective observational study. Serum were measured on admission association multiple organ dysfunction syndrome (MODS) was explored using logistic regression. SETTING: Emergency department PICU a tertiary children’s hospital, Queensland, Australia. PATIENTS:...
Importance The novel Phoenix Sepsis Score and sepsis criteria were derived validated using a multicountry dataset proposed as new definition for in children. Objective To externally validate the cohort of children hospitalized with suspected community-acquired sepsis. Design, Setting, Participants This diagnostic study used data from multicenter, Epidemiology Australian New Zealand Emergency Departments (SENTINEL) study, collected 2021 to 2023 including 90-day follow-up. Children admitted...
The Paediatric Research in Emergency Departments International Collaborative (PREDICT) has operated as an emergency research network Australia and Aotearoa New Zealand for 20 years. A focus on both knowledge generation and, over the last decade, translation produced more than 200 publications. Active sites have increased from original 12 to 47, with enhanced representation of where children acute illness present countries. We outline ongoing challenges across network, which will be relevant...
Abstract Background/aims Despite evidence that preferential use of balanced/buffered fluids may improve outcomes compared with chloride-rich 0.9% saline, saline remains the most commonly used fluid for children septic shock. We aim to determine if resuscitation as part usual care will outcomes, in through reduced kidney injury and without an increase adverse effects, Methods The Pragmatic Pediatric Trial Balanced versus Normal Saline Fluid Sepsis (PRoMPT BOLUS) study is international,...
Abstract Background There are no medications known that improve the outcome of infants with bronchiolitis. Studies have shown management bronchiolitis to be varied. Objectives To describe medication use at seven study hospitals from a recent multi‐centre randomised controlled trial on hydration in (comparative rehydration [CRIB]). Methods A retrospective analysis extant data between 2 months (corrected for prematurity) and 12 age admitted identified through CRIB trial. records, medical...
A challenge of conducting research in critically ill children is that the therapeutic window for intervention may be too short to seek informed consent prior enrolment. In specific circumstances, most international ethical guidelines allow enrolled with obtained later, termed deferred (DC) or retrospective consent. There a paucity data on attitudes parents this method enrolment paediatric emergency research. To explore concept DC and expand knowledge limitations these situations. Children...
To determine the prevalence of traumatic brain injuries in children who vomit after head injury and identify variables from published clinical decision rules (CDRs) that predict increased risk.Secondary analysis Australasian Paediatric Head Injury Rule Study. Vomiting characteristics were assessed correlated with CDR predictors presence clinically important (ciTBI) or on computed tomography (TBI-CT). Isolated vomiting was defined as without other predictors.Of 19 920 enrolled, 3389 (17.0%)...
Background Clinical decision rules (CDRs) are commonly used to guide imaging decisions in cervical spine injury (CSI) assessment despite limited evidence for their use paediatric populations. We set out determine CSI incidence, rates and the frequency of previously identified risk factors, thus assess projected impact on if CDRs were strictly applied as a rule our population. Methods A single-centre prospective observational study all aged under 16 years presenting possible tertiary...
Importance Ileocolic intussusception is an important cause of intestinal obstruction in children. Reduction ileocolic using air or fluid enema the standard care. This likely distressing procedure usually performed without sedation analgesia, but practice variation exists. Objective To characterize prevalence opioid analgesia and assess their association with perforation failed reduction. Design, Setting, Participants cross-sectional study reviewed medical records children aged 4 to 48 months...
Sepsis affects 25.2 million children per year globally and causes 3.4 deaths, with an annual cost of hospitalisation in the USA US$7.3 billion. Despite being common, severe expensive, therapies outcomes from sepsis have not substantially changed decades. Variable case definitions, lack a reference standard for diagnosis broad spectrum disease hamper efforts to evaluate that may improve outcomes. This landscape analysis community-acquired childhood Australia New Zealand will characterise...
Clinical practice guidelines (CPGs) are an important tool for the management of children with sepsis. The quality, consistency and concordance Australian New Zealand (ANZ) childhood sepsis CPGs Commission on Safety Quality in Healthcare (ACSQHC) clinical care standards international is unclear.