A5036818230- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Musculoskeletal pain and rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Peripheral Neuropathies and Disorders
- Spine and Intervertebral Disc Pathology
- Natural product bioactivities and synthesis
- Neurotransmitter Receptor Influence on Behavior
- Cancer Treatment and Pharmacology
- Ion channel regulation and function
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Inflammatory Myopathies and Dermatomyositis
- Alzheimer's disease research and treatments
- Phytochemical compounds biological activities
- Phytochemistry and Bioactivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Nuclear Receptors and Signaling
- Parasitic Diseases Research and Treatment
- Biochemical Acid Research Studies
- Inflammatory Bowel Disease
- Sleep and Wakefulness Research
- Celiac Disease Research and Management
- Bioactive natural compounds
The University of Queensland
2014-2024
Queensland Children’s Hospital
2024
Khalifa University of Science and Technology
2024
Mayne Pharma (Australia)
2022
University Hospitals Birmingham NHS Foundation Trust
2020
Queen Elizabeth Hospital
2020
Sahyadri Hospital
2019
University of Pennsylvania
2016-2017
Philadelphia VA Medical Center
2016-2017
Philadelphia University
2017
Sepsis is a life-threatening disease caused by dysregulated host response to infection, resulting in 11 million deaths globally each year. Vascular endothelial cell dysfunction results the loss of barrier integrity, which contributes sepsis-induced multiple organ failure and mortality. Erythropoietin-producing hepatocellular carcinoma (Eph) receptors their ephrin ligands play key role vascular disruption but are currently not therapeutic target sepsis. Using cecal ligation puncture (CLP)...
Abstract Neuropathic pain may affect patients with multiple sclerosis ( MS ) even in early disease. In an experimental autoimmune encephalomyelitis EAE )‐mouse model of , chronic alpha lipoic acid ALA treatment reduced clinical disease severity, but ‐neuropathic was not assessed. Hence, we investigated the pain‐relieving efficacy and mode action using our optimized relapsing‐remitting RR )‐ mouse ‐associated neuropathic pain. C57 BL /6 mice were immunized MOG 35‐55 adjuvants (Quil A...
Background: Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory distress syndrome–coronavirus-2 (SARS-CoV-2), is primarily a infection but has been recently associated with variety of neurological symptoms. We present herewith COVID-19 case manifesting as opsoclonus-myoclonus syndrome (OMS), rare disorder. Case Presentation: A 63-year-old male diagnosed developed behavioral changes, confusion, and insomnia followed reduced mobility abnormal eye movements within 48 h...
A study was conducted to identify constituents that might be responsible for analgesic and antiinflammatory conditions. Tasumatrol B, 1,13-diacetyl-10-deacetylbaccatin III (10-DAD) 4-deacetylbaccatin (4-DAB) were isolated from the bark extract of Taxus wallichiana Zucc. All compounds assessed activities using an acetic acid-induced writhing model, a hot-plate test, carrageenan-induced paw oedema cotton-pellet model in vitro lipoxygenase inhibitory assay. compounds, especially tasumatrol...
Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of infarction Get access Meredith A Redd, Redd Institute for Molecular Bioscience, University Queensland, 306 Carmody Road, St.Lucia, QLD 4072, AustraliaCritical Care Research Group, The Prince Charles Hospital Northside Clinical Unit and Faculty Medicine, Australia Search other works by this author on: Oxford Academic PubMed Google Scholar Yusuke Yoshikawa, Yoshikawa School Biomedical Sciences,...
Previous studies have shown that skin disease in dermatomyositis (DM) is best assessed using the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI). Although CDASI has been validated for use by dermatologists, it not other physicians such as rheumatologists neurologists, who also manage patients with DM assess activity clinical trials.To reliability of among neurologists.Fifteen cutaneous were Physician Global Assessment (PGA) five neurologists.The mean scores neurologists...
The Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) Assessment Tool-Binary Method (CAT-BM) have been shown to be reliable valid outcome measures assess cutaneous disease in adult dermatomyositis (DM) juvenile DM (JDM), respectively.This study compared the CDASI CAT-BM for use by paediatric dermatologists, rheumatologists neurologists patients with JDM.Five five each evaluated 14 JDM using CDASI, CAT-BM, skin Physician Global (PGA) scales. Inter-rater reliability,...
Abstract Purpose Highlight and characterize manifestations, diagnostic/management approaches outcomes in a contemporary cohort of patients with pituitary metastases (PM) from large European center—over 10 years. Methods Retrospective review PM cases between 1/2009 12/2018. Clinical, laboratory, imaging data at detection during follow-up were analysed. Results 18 identified (14 females; median age diagnosis 61.5 years). Most common primary malignancies lung (39%) breast (32%). frequent...
Antibacterial and antifungal activities of the two isolated compounds from Conyza canadensis have been reported in current study. The i.e. Conyzolide (1) Conyzoflavone (2) were tested against six bacterial five fungal strains, employing hole diffusion macrodilution methods. Both showed significant pathogens with special reference to E. coli, P. aeruginosa, S. aureus, Trichophytom longifusus, C. albicans, glaberata. revealed comparatively better antibacterial activity coli (minimum inhibitory...
In the majority of patients with breast cancer in advanced stages, skeletal metastases are common, which may cause excruciating pain. Currently available drug treatments for relief cancer-induced bone pain (BCIBP) include non-steroidal anti-inflammatory drugs and strong opioid analgesics along inhibitors osteoclast activity such as bisphosphonates monoclonal antibodies denosumab. However, these medications often lack efficacy and/or they produce serious dose-limiting side effects. present...
Multiple sclerosis (MS) is an autoimmune disease involving demyelination and axonal damage in the central nervous system (CNS). In this study, we investigated pathological changes lumbar spinal cord of C57BL/6 mice induced with progressive experimental encephalomyelitis (EAE) using 9.4-T magnetic resonance imaging (MRI). Multiparametric MRI measurements including MR spectroscopy, diffusion tensor (DTI) volumetric analyses were applied to detect metabolic CNS EAE mice. Compared healthy mice,...
Recent preclinical and proof-of-concept clinical studies have shown promising analgesic efficacy of selective small molecule angiotensin II type 2 (AT2) receptor antagonists in the alleviation peripheral neuropathic pain. However, their cellular molecular mechanism action requires further investigation. To address this issue, groups adult male Sprague-Dawley rats with fully developed unilateral hindpaw hypersensitivity, following chronic constriction injury (CCI) sciatic nerve, received a...
Colon cancer is the third most diagnosed worldwide, followed by lung and breast cancer. Conventional treatment methods are associated with numerous side effects compliance issues. Thus, colon targeted drug delivery has gained much attention due to its evident advantages. Although many technologies have been explored, use of pH-sensitive polymers, especially biodegradable holds exceptional promise. This review aims collate research articles concerning recent advances in this area. A...
The study evaluated the adulterants in a specimen of illicit street heroin supplied under strict control by Pakistan Anti-Narcotic Force. It also examined effects Hypericum perforatum L. extracts on naloxone-induced withdrawal syndrome. GC-MS analysis showed that addition to (37.8%), sample contained caffeine (8.4%), phenobarbitone (12.7%), 6-acetyl codeine (5.3%), morphine (10.9%) and noscapine (15.8%). Administration rats for 8 days induced physical signs abdominal constriction, diarrhoea...
Chronic low back pain (LBP) ranks among the most common reasons for patient visits to healthcare providers. Drug treatments often provide only partial relief and are associated with considerable side-effects. J-2156 [(1'S,2S)-4amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide] is an agonist that binds nanomolar affinity rat human somatostatin receptor type 4 (SST4 receptor). Hence, our aim was assess efficacy of chronic mechanical LBP in a model. Male...