A5042404756- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Probiotics and Fermented Foods
- Animal Virus Infections Studies
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Kruppel-like factors research
- Fullerene Chemistry and Applications
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Histone Deacetylase Inhibitors Research
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- 2D Materials and Applications
- Cell death mechanisms and regulation
- Microtubule and mitosis dynamics
- Sphingolipid Metabolism and Signaling
- Mechanisms of cancer metastasis
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
The University of Queensland
2018-2024
Queensland Children’s Hospital
2024
Henan University of Science and Technology
2024
Northeast Agricultural University
2024
Institute of Zoology
2024
Chinese Academy of Sciences
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Anhui University
2023
First Affiliated Hospital of Zhengzhou University
2021-2023
Objective: To investigate the relationship between hypoxia and in vitro "stemness" of cancer stem cells (CSCs).Methods: U87 cells, U251 primary glioma (n=3) experienced hypoxia.Transmission electron microscopy was done to detect ultrastructure these cells; MTT assay cell growth; flow cytometry cycle CD133 expression; Transwell chamber carried out migration; colony-forming efficiency; real-time quantitative PCR Western blot were mRNA protein expression markers their differentiation,...
Sepsis is a life-threatening disease caused by dysregulated host response to infection, resulting in 11 million deaths globally each year. Vascular endothelial cell dysfunction results the loss of barrier integrity, which contributes sepsis-induced multiple organ failure and mortality. Erythropoietin-producing hepatocellular carcinoma (Eph) receptors their ephrin ligands play key role vascular disruption but are currently not therapeutic target sepsis. Using cecal ligation puncture (CLP)...
The heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this is established unknown. Here, we show that Carm1 mRNA a variety specific exon-skipping splicing (ESS) isoforms in two-cell to four-cell embryos contribute heterogeneity. Disruption paraspeckles promotes the ESS precursor mRNAs (pre-mRNAs). LincGET, but not Neat1, required for paraspeckle assembly and inhibits pre-mRNAs embryos. We further find LincGET recruits gene locus through HNRNPU....
NAFLD is considered as the hepatic manifestation of metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH a progressive stage with severe steatosis, hepatocyte death, inflammation, fibrosis. Currently, no pharmacological interventions specifically tailored for are approved. Ovarian tumor domain, ubiquitin aldehyde binding 1 (OTUB1), founding member deubiquitinases, regulates many metabolism-associated signaling pathways. However, role OTUB1 in unclarified.
Aim: Long non-coding RNAs (LncRNAs) have been identified to play a crucial role in tumorigenesis and the progression of many types tumors.However, clinical significance biological function lncRNA nuclear-enriched abundant transcript 1(NEAT1) human osteosarcoma remains unknown.Here, we investigated NEAT1 cell lines tumor samples.Methods: In this study, expression was analyzed 19 tissues paired adjacent non-tumor by using quantitative real-time PCR.Additionally, knockdown Lentivirus-mediated...
Seawater (SW) inhalation can induce acute lung injury (ALI) and respiratory distress syndrome (ARDS). In the present study, SW induced apoptosis of rat alveolar epithelial cells histopathological alterations to tissue. Furthermore, administration increased generation reactive oxygen species (ROS), whereas pretreatment with ROS scavenger, N‑acetyl‑L‑cysteine (NAC), significantly decreased generation, alterations. addition, exposure upregulated expression levels glucose‑regulated protein 78...
Arylamine <i>N</i>-acetyltransferase 1 (NAT1) is a drug-metabolizing enzyme that influences cancer cell proliferation and survival. However, the mechanism for these effects unknown. Because of previous observations NAT1 inhibition decreases invasiveness, we investigated expression metalloproteinase matrix 9 (MMP9) in human breast samples cells. We found negative correlation between MMP9 1904 samples. Moreover, when was deleted highly invasive cells, mRNA protein significantly increased, both...
Reducted arylamine N-acetyltransferase (NAT1) in breast cancers is associated with poor patient survival. NAT1 has also been changes cancer cell survival and invasion both vitro vivo. Here, we report the effects of by addressing its role adherence, migration, vitro. The gene was deleted MDA-MB-231, HT-29 HeLa cells using CRISPR/Cas9 editing. Loss increased adherence to collagen all three cell-lines but migration unaffected. deletion decreased induced morphology. These were independent matrix...
Comprehensive Summary A transition‐metal free three‐component coupling reaction of azaindoles, C 60 , and bromoalkanes/triphenylamines has been developed to provide an efficient access diverse azaindole functionalized 1,4‐C adducts. This protocol exhibits low cost, operational simplicity, wide substrate scope, mild convenient conditions.
The significance of periodic tryptophan protein 1 (PWP1) expression in human cancer and its molecular mechanism action have not been reported so far.Immunohistochemistry was performed to analyze the PWP1 non-small cell lung (NSCLC) tissues statistical analysis applied relationship between clinicopathological factors. effects on NSCLC proliferation invasion were determined by colony formation, transwell MTT assays. Western blot (WB), dual-luciferase reporter gene assays immunofluorescence...
Background Restenosis is one of the main bottlenecks in restricting further development cardiovascular interventional therapy. New signaling molecules involved progress have continuously been discovered; however, specific molecular mechanisms remain unclear. MTMR14 (myotubularin‐related protein 14) a novel phosphoinositide phosphatase that has variety biological functions and diverse processes. However, role vascular biology remains Herein, we addressed neointima formation smooth muscle cell...
Abstract Two‐dimensional (2D) materials are newly developed for their thickness‐dependent physical and chemical properties. The major characteristic of this type material is that the planar structure flaunts a large surface‐to‐volume ratio, thereby providing platform straightforward easy functionalization with moieties, which prompting us to use it as sensor. We designed synthesized two types 2D metal‐organic frameworks based on functionalized anthracene derivative...
The tumor suppressor p53 serves important roles in cell cycle arrest and apoptosis, its activation increases the sensitivity of cancer cells to radiotherapy or chemotherapy. In present study, small molecule 2-[1-(4-(benzyloxy)phenyl)-3-oxoisoindolin-2-yl)-2-(4-methoxyphenyl)] acetic acid (CDS-3078) significantly increased mRNA expression levels a dose-dependent manner. Treatment with CDS-3078 p53-mediated downstream target genes HeLa cells. Additionally, p53<sup>+/+</sup> treated presented...
This study was to investigate cell proliferation regulated by reactive oxygen and nitrogen species their scavengers. Earlier conclusions are paradoxical on roles that scavengers enhance or inhibit cancer proliferations. employed the MTS assay evaluate proliferations of HepG2 cells treated with various concentrations two different nitric oxide donors, hydrogen peroxide for 24 hours. The revealed low SNP, SNAP H2O2 can significantly proliferation, high cPTIO inhibited proliferation....