A5076061804- Catalytic C–H Functionalization Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Fullerene Chemistry and Applications
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Spine and Intervertebral Disc Pathology
- Synthesis and Properties of Aromatic Compounds
- Spinal Fractures and Fixation Techniques
- Marine Sponges and Natural Products
- Synthesis and Biological Evaluation
- Bioactive Natural Diterpenoids Research
- Traditional and Medicinal Uses of Annonaceae
- Carbon Nanotubes in Composites
- Asymmetric Synthesis and Catalysis
- Pelvic and Acetabular Injuries
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Medical Imaging and Analysis
- Synthesis of Indole Derivatives
Anhui University
2016-2025
Zhejiang University
2014-2024
Jinhua Central Hospital
2017-2024
Zhejiang Lab
2024
Ministry of Education of the People's Republic of China
2022-2023
University of California, Berkeley
2020-2022
Hefei University
2017-2021
Westlake University
2021
State Council of the People's Republic of China
2017-2020
Shanghai Centennial Scientific (China)
2019
In the last few years, visible-light initiated organic transformations have attracted increasing attention. The development of visible-light-promoted photocatalytic reactions, which enable rapid and efficient synthesis fine chemicals, is highly desirable from viewpoint cost, safety, availability, environmental friendliness. this Minireview, recent advances made in fast developing area research are discussed.
Visible-light-induced radical decarboxylative functionalization of carboxylic acids and their derivatives has recently received considerable attention as a novel efficient method to create CC CX bonds. Generally, this visible-light-promoted decarboxylation process can smoothly occur under mild reaction conditions with broad range substrates an excellent functional-group tolerance. The species formed from the step participate in not only single photocatalytic transformations, but also...
Abstract Organische Umsetzungen, die durch sichtbares Licht ausgelöst werden, finden seit einigen Jahren immer größere Aufmerksamkeit. Insbesondere im Hinblick auf Kosten, Sicherheit, Verfügbarkeit und Umweltfreundlichkeit ist Entwicklung solcher photokatalytischer Reaktionen zur effizienten Herstellung von Feinchemikalien höchst wünschenswert. In diesem Kurzaufsatz werden jüngsten Fortschritte sich schnell entwickelnden Forschungsgebiet erörtert.
Abstract A photocatalytic formal [3+2] cycloaddition of 2 H ‐azirines with alkynes has been achieved under irradiation by visible light in the presence organic dye photocatalysts. This transformation provides efficient access to highly functionalized pyrroles good yields and applied synthesis drug analogues. primary trial photocascade catalysis merging energy transfer redox neutral reactions was shown be successful.
An unprecedented α-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual process, the catalytic generation allyl radical from corresponding π-allylpalladium intermediate without additional metal reducing reagents (redox-neutral). Various allylation products were obtained in high yields through cross-coupling under mild reaction conditions. Moreover, transformation applied to formal synthesis 8-oxoprotoberberine derivatives...
Abstract A novel and efficient CP bond formation reaction of diarylphosphine oxides with aryl iodides was achieved by combining nickel catalysis visible‐light‐induced photoredox catalysis. This dual‐catalytic showed a broad substrate scope, excellent functional group tolerance, afforded the corresponding products in good to yields. Compared previously reported use photoredox/nickel dual construction CC bonds, methodology described herein observed be first allow for C‐heteroatom formation.
The inorganic-organic interface between metal catalysts and their substrates greatly influences reaction processes, but few studies of this have been conducted for a detailed understanding its structure. Herein, we describe the synthesis structural determination an arylthiolated Au25(F-Ph)18- nanocluster characterize in detail key roles ligands photocatalyzed oxidative functionalization reactions. most significant findings are that (i) interactions established to avoid distortion geometric...
In this feature article, we focus on the photochemical strategy for construction of heterocyclic skeletons, specifically highlighting methods that employ visible light-promoted carbene transfer reactions.
Abstract Carbocyclic and heterocyclic ring systems are important structural architectures in many bioactive natural products, as well a variety of fine chemicals. The utilization visible‐light photocatalytic strategies to construct these has received considerable attention the past few years. This microreview presents brief summary use photoredox catalytic for synthesis carbocyclic targets.
A new and efficient synthesis of highly substituted tetrahydroimidazole derivatives by means visible light-induced intramolecular cyclization reactions has been described. This photoredox catalytic reaction exhibited high diastereoselectivity afforded the desired products in good yields.
Abstract Der radikalischen decarboxylierenden Funktionalisierung von Carbonsäuren und ihren Derivaten mithilfe sichtbarem Licht wird seit einiger Zeit erhöhte Aufmerksamkeit zuteil, da sie ein neuartiges effizientes Verfahren zur Knüpfung C‐C‐ C‐X‐Bindungen ist. Dieses lässt sich unter milden Reaktionsbedingungen auf eine breite Palette Substraten anwenden toleriert Vielzahl funktioneller Gruppen. Die bei der Decarboxylierung gebildeten Radikale können nicht nur für photokatalytische...
A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic route to 2,4,5-trisubstituted oxazoles from easily accessible 2H-azirines and aldehydes under mild reaction conditions. The potential of this strategy was further demonstrated by the rapid synthesis cyclooxygenase-2 inhibitor as well success employing electron-deficient alkenes imines partners.
An efficient, photoredox-catalyst-free radical alkylation of quinoxalin-2(1H)-ones has been described. This reaction utilizes 4-alkyl-1,4-dihydropyridines (R-DHPs) as alkyl precursors and acetoxybenziodoxole (BI-OAc) an electron acceptor to undergo single-electron transfer with photoexcited R-DHPs. The benign conditions allow for good compatibility in the scope both synthetic value protocol was also demonstrated by successful functionalization natural products drug-based complex molecules
A novel and efficient construction of isoquino[2,1-a][3,1]oxazine isoquino[2,1-a]pyrimidine frameworks has been realized by means visible light photocatalytic reactions using air as the oxidant at room temperature. This strategy offers a direct rapid access to two kinds biologically important fused heterocycles in good excellent yields.
Heterocyclic compounds are widely found in many natural isolates and medicinally relevant compounds, as well some fine chemicals. The development of general efficient methods for the construction heterocyclic is one most important tasks synthetic organic chemistry. Along these lines, [3+m]-cycloaddition reactions involving situ generated azaoxyallyl cations 3-atom units have emerged a powerful method synthesis nitrogen-containing heterocycles. In this feature article, we highlight recent...
Cascade radical cyclization of 1,6-enynes for the synthesis biologically important γ-lactams containing alkenyl C-X bonds is reported. In these cascade processes, three new chemical bonds, including C-S, C-C, and are formed in one step. The method attractive valuable due to its mild reaction conditions, broad substrate scope, importance corresponding γ-lactam products.
A silver(I) and base-mediated [3 + 3]-cycloaddition reaction of in situ generated C,N-cyclic azomethine imines with formed aza-oxyallyl cations is reported. This one-pot cycloaddition process shows broad substrate scope an excellent functional group tolerance provides the corresponding biologically important isoquinoline-fused triazines good to yields.
Abstract A method for the synthesis of 3‐acyl quinoxalin‐2(1 H )‐ones through visible‐light promoted decarboxylative acylation α‐oxo‐carboxylic acids with was developed. The reaction performed in aqueous phase and photoredox catalyst not required to run process. magnified image
We develop a visible light-promoted divergent cycloaddition of α-diazo esters with hexahydro-1,3,5-triazines, leading to series aziridine and imidazolidine frameworks in average good yield, by simply changing the reaction media used. It is noteworthy that occurs under sole light irradiation without need for exogenous photoredox catalysts. More significantly, reasonable mechanism was proposed on basis control experiments density functional theory calculation results.
Carbene is one of the most important synthetic intermediates in organic synthesis.In past few decades, transition-metal catalyzed carbene transfer reactions have made remarkable development.Recently, visible light-promoted transformation diazo compounds through formation free as key intermediate begun to rise.The reaction only need light sole energy source which meets concept green chemistry.Since pioneering works developed by groups Diaves and Zhou, photo-promoted has attracted more...