A5022029674- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Advanced machining processes and optimization
- Autophagy in Disease and Therapy
- Surgical Sutures and Adhesives
- Advanced Surface Polishing Techniques
- Advanced SAR Imaging Techniques
- Inflammasome and immune disorders
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Sirtuins and Resveratrol in Medicine
- Dental Implant Techniques and Outcomes
- Pressure Ulcer Prevention and Management
- biodegradable polymer synthesis and properties
- Advanced Machining and Optimization Techniques
- Extracellular vesicles in disease
- Aerogels and thermal insulation
- Burn Injury Management and Outcomes
- Nerve injury and regeneration
- Facial Trauma and Fracture Management
- Geophysical Methods and Applications
- Advanced biosensing and bioanalysis techniques
- Metal and Thin Film Mechanics
- RNA Interference and Gene Delivery
- Seaweed-derived Bioactive Compounds
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Wenzhou Medical University
2016-2025
Changsha University of Science and Technology
2010-2024
Shanghai Tunnel Engineering (China)
2023
First Affiliated Hospital of Wenzhou Medical University
2019-2021
South China University of Technology
2012-2018
Wenzhou University
2017-2018
Education Department of Hunan Province
2015-2017
Beijing Institute of Technology
2010-2016
National Research Center for Rehabilitation Technical Aids
2012-2015
Rationale: Chronic nonhealing diabetic wound therapy and complete skin regeneration remains a critical clinical challenge. The controlled release of bioactive factors from multifunctional hydrogel was promising strategy to repair chronic wounds. Methods: Herein, for the first time, we developed an injectable, self-healing antibacterial polypeptide-based FHE (F127/OHA-EPL) with stimuli-responsive adipose-derived mesenchymal stem cells exosomes (AMSCs-exo) synergistically enhancing healing...
Diabetic wound healing and angiogenesis remain a worldwide challenge for both clinic research. The use of adipose stromal cell derived exosomes delivered by bioactive dressing provides potential strategy repairing diabetic wounds with less scar formation fast healing. In this study, we fabricated an injectable adhesive thermosensitive multifunctional polysaccharide-based (FEP) sustained pH-responsive exosome release promoting FEP possessed properties including efficient antibacterial...
Abstract Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates transition from inflammation proliferation phase has been proved be an effective way improve diabetic healing. Herein, phenotype‐enabled anti‐inflammatory, antioxidant, antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid repair are reported....
Abstract To eliminate the negative effect of traditional metal-working fluids and achieve sustainable manufacturing, usage nano-enhanced biolubricant (NEBL) is widely researched in minimum quantify lubrication (MQL) machining. It’s improved tool wear surface integrity have been preliminarily verified by experimental studies. The previous review papers also concluded major influencing factors processability including nano-enhancer lubricant types, NEBL concentration, micro droplet size, so...
Diabetic wound repair and skin regeneration remains a worldwide challenge due to the impaired functionality of re-vascularization. Methods: This study reports bioactive self-healing antibacterial injectable dual-network silica-based nanocomposite hydrogel scaffolds that can significantly enhance diabetic healing/skin tissue formation through promoting early angiogenesis without adding any factors. The scaffold comprises main network polyethylene glycol diacrylate (PEGDA) forming scaffolds,...
The repair of diabetic wounds remains challenging, primarily due to the high-glucose-derived immune inhibition which often leads excessive inflammatory response, impaired angiogenesis, and heightened susceptibility infection. However, means reduce immunosuppression regulate conversion M2 phenotype macrophages under a high-glucose microenvironment using advanced biomaterials for are not yet fully understood. Herein, we report two-dimensional carbide (MXene)-M2 macrophage exosome (Exo)...
Treatment of diabetic wounds with a rapid healing performance remains critical clinical challenge. An extracellular matrix (ECM)-biomimetic structure has shown promise in promoting tissue regeneration through mediating cellular microenvironment. Herein, we report bone ECM-biomimetic cell-free nanofibrous scaffolds for enhancing full-thickness wounds. This bioactive was composed ECM-componential collagen (Col, mimicking protein), polycaprolactone (PCL), and glass nanoparticles (BGNs,...
The tissue reconstruction of diabetic wounds mainly depends on the proliferation and remodelling cutaneous cells around transplantation random skin flaps, however, or survival flaps are difficult due to severe inflammation other problems caused by diabetes. stem cell-derived exosomes loaded with miRNA can be an effective therapeutic strategy for promoting wound healing. Therefore, in this study, engineered derived from miR-132-overexpressing adipose (miR-132-exo) was obtained healing flaps....
This study aimed to investigate the effect of bioactive glasses on cutaneous wound healing in both normal rats and streptozotocin-induced diabetic rats. Bioactive glass ointments, prepared by mixing sol–gel 58S (SGBG-58S), nanobioactive (NBG-58S) melt-derived 45S5 (45S5) powder with Vaseline (V) at 18% weight percentage, were used heal full thickness excision wounds. Pure V was as control this study. Compared SGBG-58S, NBG-58S consists relatively dispersible nanoparticles smaller size. The...
Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated wound healing. Melatonin, a major secretory product of the pineal gland, promotes healing; however, its mechanism action remains unclear. Here, EPCs were isolated from bone marrow mice. Treatment with melatonin alleviated advanced glycation end (AGE)-induced cellular dysfunction. We further examined autophagy flux after treatment found increased light chain 3...
The lack of safe and efficient drug gene delivery vectors has become a major obstacle for the clinical applications nonviral therapy. To date, vectors, most studies are focused on cationic polymers, liposomes, modified inorganic nanoparticles which have shown high cellular toxicity, low transfection efficiency, or nondegradation. Additionally, few biodegradable biomaterials demonstrate intrinsic binding abilities to both gene. Bioactive glasses (BGs) achieved successful in bone regeneration...
The ability of biomaterials to induce rapid vascular formation is critical in tissue regeneration. Combining recombinant angiogenic growth factors with bioengineered constructs have proven be difficult due several issues, including the instability proteins, need for sustained delivery and dosage factors. New formulations bioactive glass, 58S nanosized glass (58S-NBG), been reported enhance wound healing animal models better than first generation 45S5 Bioglass. Therefore, we investigated...
Abstract Avascular necrosis frequently occurs as a complication following surgery involving the distal perforator flap. Dihydrocapsaicin (DHC) can protect tissue from ischemia–reperfusion (I/R) injury, but its specific role in multizone flaps remains unclear. In this study, prospective target of DHC context I/R injury was predicted using network pharmacology analysis. Flap viability determined through survival area analysis, laser Doppler blood flow, angiograms, and histological examination....
Attenuating oxidative stress-induced damage and promoting endothelial progenitor cell (EPC) differentiation are critical for ischaemic injuries. We suggested monotropein (Mtp), a bioactive constituent used in traditional Chinese medicine, can inhibit mitochondrial dysfunction stimulate bone marrow-derived EPC (BM-EPC) differentiation. Results showed Mtp significantly elevated migration tube formation of BM-EPCs prevented tert-butyl hydroperoxide (TBHP)-induced programmed death through...
Synthesis of radial mesoporous bioactive glass particles to deliver osteoactivin gene.