A5100342818- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Spondyloarthritis Studies and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Bone Metabolism and Diseases
- Autophagy in Disease and Therapy
- Wound Healing and Treatments
- Connective tissue disorders research
- Circular RNAs in diseases
- Aortic Disease and Treatment Approaches
- Lung Cancer Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Adipose Tissue and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Hydrogen's biological and therapeutic effects
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
- Hernia repair and management
Wenzhou Medical University
2023-2025
First Affiliated Hospital of Wenzhou Medical University
2023-2025
Sun Yat-sen University
2020-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Key Laboratory of Guangdong Province
2020-2025
Anhui Medical University
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
First Affiliated Hospital of Zhengzhou University
2022
In 2016, an estimated 1.1 million persons had human immunodeficiency virus (HIV) infection in the United States; 38,700 were new infections. Knowledge of HIV status, behavior change, and antiretroviral therapy (ART) all prevent transmission. Persons who achieve maintain viral suppression (achieved by most within 6 months starting ART) can live long, healthy lives pose effectively no risk transmission to their sexual partners.A model was used estimate rates 2016 along continuum care. Data for...
Inadequate tendon healing and heterotopic bone formation result in substantial pain disability, yet the specific cells responsible for remain uncertain. Here we identify a CD26+ stem/progenitor residing peritendon, which constitutes primitive stem cell population with self-renewal multipotent differentiation potentials. migrate into midsubstance tenocytes during healing, while ablation of these led to insufficient healing. Additionally, contribute ossification Tenascin-C-Hippo signaling is...
The aim of this study was to identify the role tenascin-C (TNC) in entheseal new bone formation and explore underlying molecular mechanism.Ligament tissue samples were obtained from patients with ankylosing spondylitis (AS) during surgery. Collagen antibody-induced arthritis DBA/1 models established observe formation. TNC expression determined by immunohistochemistry staining. Systemic inhibition or genetic ablation performed animal models. Mechanical properties extracellular matrix (ECM)...
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by back pain and spinal ankylosis due to pathological new bone formation. Here, we identified CXCL12 as critical contributor formation through recruitment of osteogenic precursor cells (OPCs). was found highly expressed in the regions that would potentially develop bone. OPCs were recruited where up-regulated. Inhibition CXCL12/CXCR4 axis with AMD3100 or conditional knockout CXCR4 attenuated migration subsequent...
The aim of this study was to identify the role Piezo1-mediated mechanotransduction in entheseal pathological new bone formation and explore underlying molecular mechanism.Spinal ligament tissues were collected from 14 patients with ankylosing spondylitis (AS) non-AS controls bulk RNA sequencing conducted. Collagen antibody-induced arthritis models established observe formation. Pharmacological inhibition genetic ablation Piezo1 performed animal essential Piezo1. Entheseal osteo-chondral...
Article1 December 2020Open Access Source DataTransparent process Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis Xiang Li Department Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Guangdong Province Key Laboratory Orthopaedics and Traumatology, ChinaThese authors contributed equally to this work Search for more papers by author Siwen Chen Zaiying Hu Rheumatology Immunology, Sixth Dongying Jianru Wang...
Abstract Adipose‐derived stem cells (ADSCs) enhance fat graft survival by promoting neovascularization. The mechanism that promotes ADSCs differentiation toward pericytes was not known. We treated with conditional medium (CM) from endothelial (ECs) or human recombinant transforming growth factor β (TGF‐β) to induce into pericytes. Pericytes markers, including platelet‐derived receptor (PDGFRβ), alpha‐smooth muscle actin (α‐SMA), and desmin, were examined. migration, their association ECs...
Abstract Background Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than women. IL-17, which mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role the development of AS. Its expression different between male and female. However, it still unclear whether sex dimorphism IL-17 contribute to differences Methods GSE221786, GSE73754, GSE25101, GSE181364 GSE205812 datasets were collected Gene Expression Omnibus (GEO) database....
A two-way relationship exists between type 2 diabetes (T2DM) and human nonalcoholic steatohepatitis (NASH). Several diabetic NASH models have the disadvantages of long cycles or inconsistent with actual incidence disease, which would be costly time-consuming to investigate disease pathogenesis develop drugs. Therefore, there is an urgent need establish a mouse model.
Purpose: To compare the sagittal alignment of different surgical approaches in patients with multiple levels cervical spondylotic myelopathy and explore relationship between patient’s health relative quality life. Method: A total 97 who underwent surgery from January 2013 to 2019 were collected this study. Patients divided into three groups: anterior discectomy fusion, corpectomy fusion laminectomy groups. Clinical outcomes parameters compared preoperative postoperative. Results: There no...
The aim of this study was to investigate using myogenic differentiation adipose stem cells for the treatment female pelvic floor dysfunction (PFD) and aimed further influences microRNA-124-3p (miR-124-3p) in process adipose-derived (ADSCs) through targeting Caveolin-1 (Cav1) during PFD Sprague Dawley (SD) rats.The ADSCs were separated from 6-8-week-old SD rats (n=25) cultivated. Then, we observed cell status conducted fat osteogenic experiments. We then constructed an ADSC-green fluorescent...
Abstract Adipose‐derived stem cells (ADSCs) have important applications in basic research, especially fat transplantation. Some studies found that three‐dimensional (3D) spheroids formed by mesenchymal enhanced therapeutic potential. However, the fundamental basics of this effect are still being discussed. ADSCs were harvested from subcutaneous adipose tissues and 3D automatic aggregation a non‐adhesive 6‐well plate. Oxygen glucose deprivation (OGD) was used to simulate transplantation...
Abstract Background Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than women. IL-17, which mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role the development of AS. Its expression different between male and female. However, it still unclear whether sex dimorphism IL-17 contribute to differences Methods GSE221786, GSE73754, GSE25101, GSE181364 GSE205812 datasets were collected Gene Expression Omnibus (GEO) database....
To investigate the effect of intermittent parathyroid hormone (iPTH) administration on pathological new bone formation during treatment ankylosing spondylitis-related osteoporosis.
To investigate the protective mechanism of dexmedetomidine (DEX) on adipose-derived stromal cells (ADSCs) under oxidative stress model and its promotion effect retention rate adipose granule transplantation by in vitro vivo experiments. The experiment was divided into control group, group (ADSCs + H 2 O +normal serum), DEX 0 +DEX drug-containing autophagy agonist +rapamycin (RAP)+normal RAP inhibitor +chloroquine (CQ)+normal CQ +CQ serum). HO-1, GSH-PX, SOD CAT ADSCs were measured. ROS...
Adipose-derived stem cells (ADSCs) have important applications in basic research, especially fat transplantation. Some studies found that three-dimensional (3D) spheroids formed by mesenchymal enhanced therapeutic potential. However, the fundamental basics of this effect are still being discussed. In study, ADSCs were harvested from subcutaneous adipose tissues and 3D automatic aggregation a non-adhesive 6-well plate. Oxygen glucose deprivation (OGD) was used to simulate transplantation...