A5100353573- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Cervical Cancer and HPV Research
- RNA Research and Splicing
- CAR-T cell therapy research
- Lipid metabolism and biosynthesis
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- PARP inhibition in cancer therapy
- Aquaculture disease management and microbiota
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
Southwestern Medical Center
2019-2025
The University of Texas Southwestern Medical Center
2002-2025
Parkland Memorial Hospital
2020-2025
Nanjing Medical University
2018-2025
Jiangsu Province Hospital
2022-2025
Minzu University of China
2022-2025
University of Science and Technology of China
2022-2025
Johns Hopkins University
2023-2025
Fuzhou University
2024-2025
Beijing University of Posts and Telecommunications
2025
A major challenge facing all law-enforcement and intelligence-gathering organizations is accurately efficiently analyzing the growing volumes of crime data. Detecting cybercrime can likewise be difficult because busy network traffic frequent online transactions generate large amounts data, only a small portion which relates to illegal activities. Data mining powerful tool that enables criminal investigators who may lack extensive training as data analysts explore databases quickly...
Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all and germline mutation-associated tumors respond. Herein we report analyses 160 breast ovarian tumors. Retention the normal allele (absence locus-specific heterozygosity (LOH)) observed in 7% ovarian, 16% 10% breast, 46% These have equivalent homologous recombination deficiency scores sporadic tumors, significantly lower than LOH (ovarian, P = 0.0004; < 0.0001, two-tailed Student's...
A halophyte refers to a plant that can naturally tolerate high concentrations of salt in the soil, and its tolerance stress may occur through various evolutionary molecular mechanisms. Eutrema salsugineum is one halophytic species Brassicaceae family multiple types abiotic stresses typically limit crop productivity, such as extreme salinity cold. It has been widely used laboratorial model for biology research plants. Here, we present reference genome sequence (241 Mb) E. at 8x coverage...
view Abstract Citations (292) References (53) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Bolometric Temperature and Young Stars in the Taurus Ophiuchus Complexes Chen, H. ; Myers, P. C. Ladd, E. F. Wood, D. O. S. We calculated bolometric temperature (Tbol) luminosity (Lbol) for 128 young stellar objects (YSOs) Taurus, 74 'core', 33 'off-core' region. have constructed luminosity-temperature (BLT) diagram, log-log plot of Lbol versus Tbol, three samples....
Two East-bloc computing knowledge bases, both based on a semantic network structure, were created automatically from large, operational textual databases using two statistical algorithms. The bases evaluated in detail concept-association experiment recall and recognition tests. In the experiment, one of which exhibited asymmetric link property, outperformed four experts recalling relevant concepts computing. base, contained 20000 (nodes) 280000 weighted relationships (links), was...
Cancer antigen-specific T cells are key components in antitumor immune response, yet their identification the tumor microenvironment remains challenging, as most cancer antigens unknown. Recent advance immunology suggests that similar T-cell receptor (TCR) sequences can be clustered to infer shared antigen specificity. This study aims identify TCRs from genomics sequencing data.We used TRUST (Tcr Repertoire Utilities for Solid Tissue) algorithm assemble TCR hypervariable CDR3 regions 9,700...
It has been reported that approximately 40% of ALI (acute lung injury) incidence resulted from sepsis. Paclitaxel, as a classic anti-cancer drug, plays an important role in the regulation inflammation. However, we do not know whether it protective effect against CLP (cecal ligation and puncture)-induced septic ALI. Our study aims to illuminate mitigative effects paclitaxel on sepsis-induced its relevant mechanisms.The survival rates organ injuries were used evaluate mice. The levels...
Scope Atherosclerosis is the underlying pathogenesis of cardiovascular events caused by inflammation, and dietary intervention has been recommended as one fundamental prevention strategy. Herein, anti‐arteriosclerotic properties quercetin are investigated modulating galectin‐3 (Gal‐3)‐NLR family, pyrin domain‐containing 3 (NLRP3) pathway. Methods results Plaques from ApoE −/− mice fed high‐fat diet (HFD) with or without (100 mg (kg·bw) −1 ) for 16 weeks, carotid plaques patients stenosis...
Abstract Background Hysteroscopy is a commonly used technique for diagnosing endometrial lesions. It essential to develop an objective model aid clinicians in lesion diagnosis, as each type of has distinct treatment, and judgments hysteroscopists are relatively subjective. This study constructs convolutional neural network that can automatically classify lesions using hysteroscopic images input. Methods All histopathologically confirmed were obtained from the Shengjing Hospital China Medical...
Endometrial carcinoma stands as the most prevalent gynecological cancer and fourth common affecting women. The incidence of endometrial has been steadily increasing over past decade, posing a significant threat to public health. early detection its precancers remains critical evolving concern reduce mortality associated with carcinoma. In last our understanding advanced through systematic investigations into molecular genetics precancers. this review, we focus on advances in endometrioid...
article Free Access Share on Automatic concept classification of text from electronic meetings Authors: H. Chen Univ. Arizona, Tucson TucsonView Profile , P. Hsu LSI Logic Corp., Freemont, CA CAView R. Orwig L. Hoopes J. F. Nunamaker Authors Info & Claims Communications the ACMVolume 37Issue 10Oct. 1994 pp 56–73https://doi.org/10.1145/194313.194322Online:01 October 1994Publication History 86citation383DownloadsMetricsTotal Citations86Total Downloads383Last 12 Months4Last 6 weeks1 Get...
In angiosperms, the endosperm provides nutrients for embryogenesis and seed germination is primary tissue where gene imprinting occurs. To identify imprintome of early developing maize (Zea mays) endosperm, we performed high-throughput transcriptome sequencing whole kernels at 0, 3, 5 d after pollination (DAP) endosperms 7, 10, 15 DAP, using B73 by Mo17 reciprocal crosses. We observed gradually increased expression paternal transcripts in 3- 5-DAP kernels. 7-DAP majority genes tested reached...
Mutations of human telomerase RNA component (TERC) and reverse transcriptase (TERT) are associated with a subset lung aging diseases, but the mechanisms by which TERC TERT participate in diseases remain unclear. In this report, we show that knock-out (KO) mouse gene Terc or Tert causes pulmonary alveolar stem cell replicative senescence, epithelial impairment, formation sacs, characteristic inflammatory phenotype. Deficiency remarkable elevation various proinflammatory cytokines, including...
Abstract Background High probability of metastasis limited the long-term survival patients with hepatocellular carcinoma (HCC). Our previous study revealed that Galectin-3 was closely associated poor prognosis in HCC patients. Methods The effects on tumour were investigated vitro and vivo, underlying biological molecular mechanisms involved this process evaluated. Results showed a close correlation vascular invasion large-scale from multiple sets. significantly diverse metastasis-related...
Rare cancers, affecting 1 in 5 cancer patients, disproportionally contribute to mortality. This research focuses on liposarcoma, an understudied rare with unknown risk factors and limited treatment options. Liposarcoma incident cases were identified from the U.S. Surveillance, Epidemiology, End Result (SEER) program combined SEER-National Program of Cancer Registries (CNPCR) between 2001–2016. Incidence rates (age-adjusted age-specific), 5-year survival, time trends determined using...
Abstract Background Psoriasis is a chronic relapsing immunological skin disease characterized by multiple cross-talk inflammatory circuits which are relevantly associated with abnormal cross-reactivity between immune cells and keratinocytes (KCs). It may be inadequate to eradicate complicated pathogenesis only via single-mode therapy. To provide optimal combinatory therapeutics, nanocomposite-based hydrogel was constructed loading methotrexate (MTX) into ZnO/Ag realize combined target...
T-cell immunoglobulin domain and mucin domain-3 (Tim-3) is a versatile immunomodulator that protects against intestinal inflammation. Necroptosis type of cell death regulates homeostasis The mechanism(s) underlying the protective role macrophage Tim-3 in inflammation unclear; thus, we investigated whether specific knockdown macrophages drives via necroptosis. protein mRNA expression were assessed double immunofluorescence staining single-cell RNA sequencing (sc-RNA seq), respectively,...
Intelligence and security informatics (ISI) is an emerging field of study aimed at developing advanced information technologies, systems, algorithms, databases for national- homeland-security-related applications, through integrated technological, organizational, policy-based approach. This paper summarizes the broad application policy context this field. Three detailed case studies are presented to illustrate several key ISI research areas, including cross-jurisdiction sharing; terrorism...
A blackboard-based document management system that uses a neural network spreading-activation algorithm which lets users traverse multiple thesauri is discussed. Guided by heuristics, the activates related terms in and converges of most pertinent concepts. The provides two control modes: browsing module an activation determine sequence operations. With module, have full over knowledge sources to browse what select. system's query formation; retrieving, ranking selection documents; thesaurus...