A5064306401- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Renal and related cancers
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Genital Health and Disease
- Lymphadenopathy Diagnosis and Analysis
- Immunotherapy and Immune Responses
- Kruppel-like factors research
- Acute Lymphoblastic Leukemia research
- Respiratory and Cough-Related Research
- Brain Metastases and Treatment
- Immune cells in cancer
- CNS Lymphoma Diagnosis and Treatment
- Cardiac tumors and thrombi
Southwestern Medical Center
2020-2025
Parkland Memorial Hospital
2020-2025
The University of Texas Southwestern Medical Center
2014-2025
Parkland Health & Hospital System
2022-2024
Endometrial carcinoma stands as the most prevalent gynecological cancer and fourth common affecting women. The incidence of endometrial has been steadily increasing over past decade, posing a significant threat to public health. early detection its precancers remains critical evolving concern reduce mortality associated with carcinoma. In last our understanding advanced through systematic investigations into molecular genetics precancers. this review, we focus on advances in endometrioid...
The prevalence and significance of programmed death-1 ligand (PD-L1) expression in different types tubo-ovarian carcinoma have not been well defined. We evaluated PD-L1 CD8 tumor-infiltrating lymphocyte (TIL) density whole tissue sections 189 cases carcinoma, including high-grade serous (HGSC, n=100), clear cell (CCC, n=24), endometrioid (EmC, n=40), mucinous carcinomas (MC, n=25). Using the tumor proportion score (TPS) with a 1% cutoff, was present 21% HGSC, 16.7% CCC, 2.5% EmC, 4% MC....
Mesonephric-like adenocarcinoma (MLA) is a newly recognized type of carcinoma that occurs in the uterus and ovaries. MLA exhibits distinct morphological immunophenotypical features similar to those mesonephric cervix or vagina, with majority reported tumors containing KRAS mutations. exceedingly rare appears be associated aggressive clinical behavior. Literature regarding behavior MLAs remains limited. Here, we report four additional patients detailed analysis, as well clinicopathological...
MEIS1-NCOA1/2 fusions are recently described gene rearrangements found in rare sarcomas, mainly involving the genitourinary and gynecologic tracts, with 3 cases reported uterine corpus. Although local recurrence was very common, no death has been reported, some investigators consider these sarcomas low grade. Amplification of genes located at 12q13-15 locus, especially MDM2 , is hallmark genetic abnormality well-differentiated dedifferentiated liposarcoma soft tissue. Some tumors have also...
Although collectively regarded as "squamous differentiation (SD)" in endometrial endometrioid carcinoma (EEC) and atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN), morules (often referred to morules") true SD may represent two distinct phenomena. Here, we explored the distinction between versus investigated association of with CTNNB1 mutations. A total 270 cases EEC AH/EIN were studied, including (n=36) or without (n=80) (n=118) morules. Cases analyzed by...
The diagnosis of atypical hyperplasia/endometrioid intraepithelial neoplasm (AH/EIN) within endometrial polyps (EMPs) often poses a diagnostic conundrum. Our previous studies demonstrated that panel immunohistochemical (IHC) markers consisting PAX2, PTEN, and β-catenin can be effectively utilized for the identification AH/EIN. A total 105 AH/EIN EMP were analyzed using 3-marker panel. We also evaluated these cases presence morules. Benign (n=90) unassociated with polyp (n=111) served as...
The pattern-based classification system of endocervical adenocarcinoma correlates with nodal metastasis and clinical outcomes, but its application in biopsies is challenging. aim this study was the correlation additional histologic features patterns invasion as well prognosis. A total 103 specimens from 71 cervical cases were studied. Among cases, all had resection including hysterectomy, cold knife cone excision or loop electrosurgical procedure excision, 32 these prior biopsies. We applied...
Background: Conservative management with progestin is a treatment option for atypical hyperplasia (AH). However, pathologic diagnosis of residual/recurrent lesions often problematic because the profound morphologic changes induced by and lack established diagnostic criteria progestin-treated residual AH. Methods: We conducted longitudinal study 265 endometrial biopsies from 54 patients history AH on therapy. Patient outcomes were divided into 3 categories after review immunohistochemical...
Programmed death-1 ligand (PD-L1) expression has been used as a predictive marker for response to immune checkpoint inhibitors and reported have prognostic value. Its prevalence significance in endocervical adenocarcinoma (ECA) remain underinvestigated. We evaluated PD-L1 CD8 + tumor-infiltrating lymphocyte density whole tissue sections of 89 ECAs. was observed 68% ECAs by combined positive score (CPS, cutoff 1) 29% tumor proportion (TPS, 1%). Using CPS, seen 11%, 78%, 72% pattern A, B, C...
Abstract Primary cardiac angiosarcoma is an exceedingly rare high‐grade malignancy of the heart originating from endothelial cells, with a predilection for right atrium in male. Clinical diagnosis extremely challenging because nonspecific symptoms and radiological findings. Although almost always presenting massive recurrent pericardial effusions, diagnosed based on fluid has rarely been reported, either due to paucity malignant cells or misdiagnosis low familiarity/suspicion lack proper...
Endometrial serous carcinoma (ESC) is an uncommon, aggressive type of endometrial cancer. While immune checkpoint blockade has emerged as a promising treatment option for carcinomas, research on the expression checkpoints that could serve prospective immunotherapy targets in ESC limited. We examined prevalence and prognostic value lymphocyte-activation gene 3 (LAG-3), T-cell immunoglobulin ITIM domain (TIGIT), V-domain (Ig) suppressor activation (VISTA), indoleamine 2,3-dioxygenase 1 (IOD1)...
Endometriosis is a common condition, with the ovary being most anatomic site. Endometriosis-particularly in ovary-is associated risk of malignant progression, histologic spectrum lesions from benign to malignant. Recently, panel 3 markers consisting β-catenin, PAX2, and PTEN has been described as potentially useful diagnostic adjunct diagnosis intrauterine endometrioid neoplasia, where aberrancy for one or more strongly neoplasia. Here, we applied ovarian lesions, including endometriosis,...
The diagnosis of endometrial atypical hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN) remains challenging and subjective in some cases, with variable histologic criteria differences opinion among gynecologic pathologists, potentially leading to under/overtreatment. There has been growing interest the use specific immunohistochemical markers as adjuncts AH/EIN diagnosis. For example, World Health Organization 2020 Classification specifies that loss Pten, Pax2, or mismatch repair...
Microcystic stromal tumors (MCSTs) are rare ovarian tumors. They harbor CTNNB1 or APC mutations, resulting in β-catenin nuclear expression. To date, all MCST cases treated with oophorectomy more extensive surgery have followed benign clinical courses. However, 1 of the 3 cystectomy/tumor resection recurred residual ovary and iliac fossa 9 years after cystectomy. Here, we report a case recurrent 38-year-old woman. The patient underwent cystectomy for 7.5 cm solid-cystic right mass, which...
To stratify the risk of cervical precancers (high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS)) cancers (squamous cell carcinoma (SCC) adenocarcinoma) based on distinct high-risk human papillomavirus (hrHPV) genotypes as well age groups among women with atypical cells undetermined significance (ASC-US) hrHPV+results.
: Aimed to potentially risk-stratify patients with different cervical cytology diagnoses, by HPV genotypes and/or age, we have conducted a series of studies examine the prevalence precancers and cancers for women diagnoses. This paper will be focusing on ASC-H/HSIL cytology.