A5100420333- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Palliative Care and End-of-Life Issues
- MicroRNA in disease regulation
- Maternal and fetal healthcare
- Circular RNAs in diseases
- COVID-19 and Mental Health
- Bone Metabolism and Diseases
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Family and Patient Care in Intensive Care Units
- Energy and Environment Impacts
- Health and Wellbeing Research
- Spondyloarthritis Studies and Treatments
- Protein Tyrosine Phosphatases
- Ubiquitin and proteasome pathways
Shanghai Jiao Tong University
2016-2025
International Peace Maternity & Child Health Hospital
2016-2025
Gansu University of Traditional Chinese Medicine
2024-2025
Anhui Medical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
First Affiliated Hospital of Gannan Medical University
2020-2023
Institute of Hematology & Blood Diseases Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Ningxia Seismological Bureau
2023
Zhejiang Hospital
2020-2022
The etiology and pathogenesis of pre-eclampsia (PE) is unclear, there no ideal early clinical biomarker for prediction PE. competing endogenous RNA (ceRNA) hypothesis a new approach to uncover the molecular pathology first aim this study was perform messenger RNA, long non-coding circular (circRNA) expression profiling human normal severe (SPE) placentas. circRNA, which has stable structure, more suitable than other types RNA. Therefore, second our select some differentially expressed...
Abstract Preeclampsia (PE) is a leading cause of maternal mortality worldwide. Several studies have detected some differentially expressed microRNAs in the preeclamptic placenta, but few identified demonstrated consistent findings among different research studies. In this study, high-throughput microRNA sequencing (HTS) 9 and normal placentas was performed. Seventeen were to be up-regulated 8 down-regulated placentas. Eight except one our study determined with at least previous while sixteen...
Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it not clear about the level and pattern impairment among this population.To provide meta-analysis systematically analysing neurocognitive MCCB in FES.An independent literature search both English databases up to 13 March 2019 was conducted by two reviewers. Standardised...
Mechanisms governing the metastasis of endometrial carcinoma (EC) are poorly defined. Recent data support a role for cell surface receptor tyrosine kinase TrkB in progression several human tumors. Here we present evidence direct EC. Immunohistochemical analysis revealed that and its secreted ligand, brain-derived neurotrophic factor (BDNF), more highly expressed EC than normal endometrium. High levels correlated with lymph node (p<0.05) lymphovascular space involvement Depletion by stable...
Tumor–stroma interactions contribute greatly to intratumoral estrogen biosynthesis in endometrial carcinoma, but the mechanisms involved remain largely unknown. Previous study demonstrated that aromatase upregulation stromal cells participated this process, specific aromatase-regulators have not been reported. In present study, we found expression stroma, tumor epithelium, correlated positively with interleukin 6 (IL-6) cancer epithelial by immunohistochemistry, which was confirmed using...
Triclosan (TCS) is an antibacterial chemical widely used in personal-care products and endocrine disruptor. While TCS exposure associated with insulin resistance metabolic disorders animals, few studies have assessed its effect on the risk of gestational diabetes mellitus (GDM) humans. This study aimed to explore whether maternal urinary level GDM infant birthweight. We examined 620 pregnant women from Shanghai, China 2012–2013. Urinary was measured high-performance liquid...
Pilomatrix-like high-grade endometrial carcinoma (PiMHEC) is a rare and aggressive variant of often misdiagnosed due to overlapping features with other malignancies. This study characterizes its clinicopathologic, immunophenotypic, molecular establish key diagnostic criteria propose standardized terminology. Ten tumors were analyzed using histopathologic examination, immunohistochemistry, next-generation sequencing. All but 1 tumor exhibited both low-grade endometrioid basaloid components,...
Background: Bisphenol A (BPA) has been associated with variable metabolic effects in animal models. It is unknown whether BPA exposure affects glucose tolerance pregnancy. We aimed to investigate maternal urinary concentration gestational diabetes mellitus (GDM). Methods: This study included 620 pregnant women from Shanghai, China 2012–2013. Maternal was measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). GDM (n = 79) diagnosed according the criteria of...
Recent data support a role for SHARP1, basic helix-loop-helix transcription repressor, in the regulation of malignant cell behavior several human cancers. However, expression and SHARP1 during development endometrial cancer (EC) remain unclear. Here we show that upregulation suppressed tumor angiogenesis by decreasing hypoxia-inducible factor-1α (HIF-1α), inhibited viability growth EC. Immunohistochemical staining showed was negatively correlated with stage, histological grade, myometrial...
Objective High prepregnancy body mass index (BMI), excessive gestational weight gain (GWG), and diabetes mellitus (GDM) are associated with the risk of childhood obesity. This study aims to examine extent which these effects may be mediated through placenta. Methods Data included 33,893 mothers their singleton infants from birth 7 years old (total 154,590 visits) in Collaborative Perinatal Project, a U.S. multicenter prospective cohort 1959 1976. The placentas were weighed after removing...
Abstract Gestational trophoblastic disease (GTD) encompasses a range of trophoblast-derived disorders. The most common type GTD is hydatidiform mole (HM). Some HMs can further develop into malignant gestational neoplasia (GTN). Aberrant expression microRNA (miRNA) widely reported to be involved in the initiation and progression cancers. MiRNA profile also has been proved useful signature for diagnosis, staging, prognosis, response chemotherapy. Till now, miRNA not determined. In this study,...
Fetal growth restriction (FGR) threatens perinatal health and is correlated with increased incidence of fetal original adult diseases. Most cases FGR were idiopathic, which supposed to be associated placental abnormality. Decreased circulating factor (PGF) was recognized as an indication deficiency in FGR. In this study, the epigenetic regulation PGF placentas involvement modulation trophoblast activity investigated. The expression level tissues determined by RT-qPCR, immunohistochemistry...
Serum amyloid A1 (SAA1) is an acute phase protein produced mainly by the liver to participate in immunomodulation both sterile and non-sterile inflammation. However, non-hepatic tissues can also synthesize SAA1. It remains be determined whether SAA1 synthesized locally placenta participates parturition via eliciting inflammatory reactions. In this study, we investigated issue using human a mouse model. We found that mRNA expression placental villous trophoblasts, which was increased upon...