A5009171057- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Extracellular vesicles in disease
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- FOXO transcription factor regulation
- Epigenetics and DNA Methylation
- Immune cells in cancer
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer and Skin Lesions
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
National Institutes of Health
2023-2025
National Cancer Institute
2023-2025
Fudan University Shanghai Cancer Center
2016-2024
The University of Texas Southwestern Medical Center
1998-2024
Yahoo (United Kingdom)
2024
The University of Texas at Dallas
2021
Southwestern Medical Center
2021
ORCID
2021
Baylor University Medical Center
2018
Shanghai Medical College of Fudan University
2016
Long noncoding RNA (lncRNA) and mRNAs are long RNAs (≥200 nucleotides) compared with miRNAs. In blood, may be protected by serum extracellular vesicles, such as apoptotic bodies (AB), microvesicles (MV), exosomes (EXO). They potential biomarkers for identifying cancer.Sera from 76 preoperative colorectal cancer patients, age- sex-matched healthy subjects, 20 adenoma patients without were collected. We investigated the distribution of into three vesicles. Seventy-nine cancer-related chosen...
PURPOSE: The purpose of this study was to determine the feasibility sentinel node identification in patients with invasive cervix cancer undergoing radical hysterectomy and pelvic lymphadenectomy using preoperative intraoperative lymphatic mapping. PATIENTS AND METHODS: Thirty-nine at two institutions were enrolled onto institutional review board–approved study. All underwent lymphoscintigraphy mapping blue dye a handheld gamma probe. Radical aborted four because metastatic disease...
The aim of the study was to investigate effects lactic acid on phenotypic polarization and immune function macrophages. human monocyte/macrophage cell line, THP‑1, selected treated with acid. Immunofluorescence staining, laser confocal microscopy, reverse‑transcription polymerase chain reaction (RT‑PCR), western blot, siRNA, ELISA analyses were used observe changes in levels cluster differentiation (CD)68, CD163, hypoxia inducible factor (HIF)‑1α, programmed death ligand‑1 (PD‑L1) as well...
Background The exploration of genetic signatures within the ovarian cancer (OC) tumor microenvironment (TME) remains limited. M2-like tumor-associated macrophages (M2-like TAMs) are pivotal in OC progression and therapy. This study aims to establish a novel prognostic signature identify TAM-related biomarkers using RNAseq-based transcriptome analysis. Methods Prognostic genes were identified through univariate Cox regression, consensus clustering, LASSO regression. Immune landscape analysis...
PURPOSE: The purpose of this study was to determine the feasibility sentinel node identification in patients with invasive cervix cancer undergoing radical hysterectomy and pelvic lymphadenectomy using preoperative intraoperative lymphatic mapping. PATIENTS AND METHODS: Thirty-nine at two institutions were enrolled onto institutional review board–approved study. All underwent lymphoscintigraphy mapping blue dye a handheld gamma probe. Radical aborted four because metastatic disease...
Norepinephrine and epinephrine, catecholamine hormones that are major mediators for chronic stress-induced cancers, implicated in the progression of a number cancer cells, including gastric adenocarcinoma. However, underlying mechanisms these have not been well elucidated. Epithelial-mesenchymal transition (EMT) is crucial event responsible cell invasion metastasis. The hypothesis regarding whether promotive effects norepinephrine (NE) on part due to its ability induce an EMT program has...
In this study, we investigated whether the metabolic alteration of cancer-associated fibroblasts (CAFs) occurs via miR-21 remodeling and effect on pancreatic cancer cells.CAFs normal (NFs) were isolated cultured.Glucose consumption lactic acid production tested, lactate dehydrogenase (LDHA), pyruvate kinase m2 (PKM2), expression examined.The level glycolysis in CAFs was determined after treatment with a inhibitor.Primary miR-21-NC miR-21-inhibitor indirectly co-cultured BxPc-3 vitro,...
Endometrial carcinoma is one of the most common malignancies in female reproductive system. It well-known that estrogen plays an important role pathogenesis endometrioid endometrial (EEC), and induces cancer suppressor gene PTEN deletion. However, how affects expression remains unknown. In present study, we found 40 EEC specimens, miR-200c level was higher areas than adjacent normal endometrium, while PTENP1 were lower. Moreover, PTEN/PTENP1 also showed a converse relationship cell lines....
Pilomatrix-like high-grade endometrial carcinoma (PiMHEC) is a rare and aggressive variant of often misdiagnosed due to overlapping features with other malignancies. This study characterizes its clinicopathologic, immunophenotypic, molecular establish key diagnostic criteria propose standardized terminology. Ten tumors were analyzed using histopathologic examination, immunohistochemistry, next-generation sequencing. All but 1 tumor exhibited both low-grade endometrioid basaloid components,...
In the 2020 World Health Organization classification of female genital tumours, endocervical adenocarcinomas (ECAs) are subclassified into human papillomavirus (HPV)-associated (HPVA) and HPV-independent (HPVI) groups on basis their distinct aetiologies clinical behaviours. The aim this study was to investigate programmed death-ligand 1 (PD-L1) expression its prognostic value in HPVI ECA HPVA ECA, compare these between two entities.A total 93 ECAs accessioned 2013 were selected for further...
Esophageal squamous cell carcinoma (ESCC) is the most popular pathology of esophageal cancer (EC) in China, especially Henan province, mid-east China. Presently, targeting DNA damage repair (DDR) factors a promising approach for therapy. Our group has been focusing on exploring DDR overexpressed ESCC tissues to provide potential targets therapies many years. RAP80/UIMC1 (ubiquitin interaction motif containing 1), one those we tested, was highly compared with adjacent normal tissues....
Abstract Objectives The characterization of DNA polymerase epsilon (POLE) mutations has transformed the classification endometrial endometrioid carcinomas (EECs), highlighting need for efficient identification methods. This study aims to examine relationship between distinct morphologic features—namely, squamous morules and differentiation (SD), as well β-catenin expression—and POLE mutation status in cancer (EC). Methods Our included 35 POLE-mutated (POLEmut) EC cases 395 non-POLEmut EEC...