A5077339926- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- RNA modifications and cancer
- Sphingolipid Metabolism and Signaling
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Kidney Disease and Diabetes
- NF-κB Signaling Pathways
- Liver physiology and pathology
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Abdominal vascular conditions and treatments
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Zhongshan Hospital
2024-2025
Fudan University
2023-2025
Xi'an Jiaotong University
2014-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Central South University
2012-2024
Nanchang University
2024
Wenzhou Medical University
2020-2024
Third Xiangya Hospital
2012-2024
Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and the underlying mechanisms are not well characterized.The expression levels of TUG1, miR-524-5p, sine oculis homeobox homolog (SIX1) were determined using quantitative real-time PCR. The regulatory relationships confirmed by dual-luciferase reporter assay. Cell proliferation invasion assessed Counting Kit 8 transwell assays. Glucose...
Abstract Objective This study aimed to evaluate the association of triglyceride-glucose (TyG) index with all-cause and cardiovascular mortality risk among patients cardiometabolic syndrome (CMS). Methods We performed a cohort 5754 individuals CMS from 2001–2018 National Health Nutrition Examination Survey. The TyG was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate Cox proportional hazards regression models assessed associations between . Non-linear...
Abstract Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as potent regulator of glucose energy metabolism, protects from various diseases, possibly by mediating autophagy. In the present study, FGF21 in progression OA was investigated vitro vivo experiments. vitro, results revealed administration alleviated apoptosis, senescence, extracellular matrix (ECM) catabolism...
Tumor recurrence after liver transplantation (LT) impedes the curative chance for hepatocellular carcinoma (HCC) patients. This study aimed to develop a deep pathomics score (DPS) predicting tumor using learning.Two datasets of 380 HCC patients who underwent LT were enrolled. Residual convolutional neural networks used identify six histological structures HCC. The individual risk each structure and DPS derived by modified DeepSurv network. Cox regression analysis Concordance index evaluate...
The role of ethylene and hydrogen peroxide (H₂O₂) in the induction alternative respiratory pathway (AP) calluses from wild-type (WT) Arabidopsis ethylene-insensitive mutant etr1-3 under salt stress was investigated. capacity contribution AP to total respiration were significantly induced by 100 mM sodium chloride (NaCl) WT but only slightly calluses. Ethylene emission enhanced stress. Application 1-aminocyclopropane-1-carboxylic acid (an precursor) further increased not Reduction production...
Accumulating evidence has shown that micro-RNAs (miRNAs) are involved in multiple processes cancer development and progression. Upregulation of miRNA-494 (miR-494) been identified as an oncogenic miRNA is associated with poor prognosis several types human cancer. However, the specific function miR-494 colorectal remains unclear. In this study we found expression tissues cell lines was much higher than normal control cells, respectively. addition, upregulation more frequently occurred tissue...
With the rapid development of sequencing technologies, especially maturity third-generation there has been a significant increase in number and quality published genome assemblies. The emergence these high-quality genomes raised higher requirements for evaluation. Although numerous computational methods have developed to evaluate assembly from various perspectives, selective use evaluation can be arbitrary inconvenient fairly comparing quality. To address this issue, we Genome Assembly...
Background: Studies have shown that coagulation and fibrinolysis (CFR) are correlated with Hepatocellular carcinoma (HCC) progression prognosis. We aim to build a model based on CFR-correlated genes for risk assessment prediction of HCC patient. Methods: samples were selected from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases respectively. Molecular Signatures Database (MSigDB) was used select the CFR genes. RiskScore established by single sample gene set enrichment...
Conditioned medium (secretome) derived from an enriched stem cell culture stimulates chemotaxis of human fibroblasts. These cells are classified as multipotent murine mesenchymal stromal (mMSC) by immunochemical analysis marker proteins. Proteomic mMSC secretome identifies nineteen secreted proteins, including extracellular matrix structural collagen processing enzymes, pigment epithelium-derived factor (PEDF) and cystatin C. Immunodepletion reconstitution experiments show that PEDF is the...
Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate effect blockade on morphology and function mitochondria human renal cells (HRGECs). HRGECs were pretreated with antagonist (JTE-013) or Rho-associated coiled coil-containing protein kinase 1 (ROCK1) inhibitor (Y27632) for 30...
Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in germinal matrix, where subsequent enters subependymal zone and cerebral lateral ventricles. The consequent clot has been identified as causative factor secondary brain injury, which triggers a series complex parallel sequential harmful mechanisms, including neuroinflammation. orphan G-protein-coupled receptor 40 (GPR40), free fatty acid (FFA) 1, shown to exert anti-inflammatory effects when activated...
Abstract Electrical stimulation (ES) therapy accelerates cartilage healing but faces challenges due to bulky equipment, necessitating the development of a lightweight, implantable, and biocompatible electrical stimulator for improved patient compliance benefits. Piezoelectric materials have garnered considerable attention their potential as self‐driven bioelectric therapies treat osteoarthritis (OA) by providing in situ ES. Accordingly, an ES exercise‐driven regeneration based on...
Abstract RNA N6-methyladenosine (m6A) is a common modification in eukaryotes, and its abnormal regulation closely related to cancer progression. Aerobic glycolysis main way for cells obtain energy. It was found that beaded filament structural protein 1 (BFSP1) m6A gene liver cancer. However, the effect of m6A-modified BFSP1 on aerobic how it regulated progression have not been explored. Here, we upregulated tissues. Overexpression promoted viability, invasion, cells, whereas knockdown showed...
Vascular endothelial cells (ECs) have a finite lifespan when cultured in vitro and eventually enter an irreversible growth arrest state called "cellular senescence." It has been shown that sphingolipids may be involved senescence; however, the molecular links are poorly understood. In this study, we investigated signaling functions of sphingosine 1-phosphate (S1P), serum-borne bioactive sphingolipid, ECs different ages. We observed S1P-regulated responses significantly inhibited S1P1-3...
Aims Cancer development and progression is not only associated with the tumor cell proliferation but also depends on interaction between cells stromal microenvironment. A new understanding of role microenvironment suggests that loss caveolin-1 (Cav-1) as a key regulator may become potential therapy target. This study aims to elucidate whether Cav-1 expression in pancreatic cancer can be strong prognosis biomarker. Methods Tissue samples from 45 patients were studied. Parenchyma stroma...
Pancreatic cancer (PC) is an aggressive and devastating disease with a poor prognosis. Cisplatin, commonly used chemotherapeutic agent for solid tumors, effective as single or in combination other drugs the treatment of PC. Previous studies have suggested that Twist growth differentiation factor 15 (GDF15) are involved progression However, role GDF15 PC remains to be elucidated. In present study, individual effect interaction between cell invasion chemoresistance cisplatin was examined....