A5101889928- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cutaneous lymphoproliferative disorders research
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pancreatitis Pathology and Treatment
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Lymphatic Disorders and Treatments
- Occupational and environmental lung diseases
- Thermal Regulation in Medicine
- Heat shock proteins research
- Phagocytosis and Immune Regulation
- Sepsis Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Intraperitoneal and Appendiceal Malignancies
- Cancer Cells and Metastasis
Zhongda Hospital Southeast University
2020-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Fred Hutch Cancer Center
1999-2019
Chongqing Three Gorges Central Hospital
2014-2019
Medical University of South Carolina
2015-2018
University of Washington
2006-2018
MUSC Hollings Cancer Center
2015-2017
Army Medical University
2015
Osaka University
2011-2012
Bastyr University
2010
Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy and resistance therapy by dampening host immunity. show genetic targeting of enhances adoptive T cell cancer. An unbiased biochemical structural biology approach established transforming growth factor β (TGFβ) lactate as major platelet-derived soluble factors obliterate CD4+ CD8+ functions. Moreover, we found are dominant...
To assess the efficacy of pembrolizumab in patients with advanced relapsed or refractory mycosis fungoides (MF) Sézary syndrome (SS).
mAb OV569 was made by immunizing mice with ovarian carcinoma cells. It binds to cells from carcinomas and, a lesser extent, certain other whereas the binding normal tissues is low nondetectable. also soluble molecule(s) in culture supernatants antigen-positive carcinomas. recognizes protein(s) of 42–45 kDa same N-terminal amino acid sequence as membrane-bound portion mesothelin and megakaryocyte potentiating factor (MPF). Binding assays fusion proteins comprising either part mesothelin/MPF...
Polysaccharide krestin (PSK) is a mushroom extract that has been long used in Asia and recently Western countries as treatment for cancer due to its presumed immune potentiating effects. Although there have reports of clinical responses after patients ingested PSK, the mechanism action agent remains undefined. The current study was undertaken investigate antitumor actions PSK.The immunostimulatory effect PSK first evaluated vitro using splenocytes from neu transgenic mice Toll-like receptor...
Protein arginine methyltransferase 5 (PRMT5) has been implicated as a key modulator of lymphomagenesis. Whether PRMT5 overt oncogenic function in the context leukemia/lymphoma and whether it represents therapeutic target remains to be established. We demonstrate that inactivation inhibits colony-forming activity by multiple drivers, including cyclin D1, c-MYC, NOTCH1, MLL-AF9. Furthermore, we overexpression specifically cooperates with D1 drive lymphomagenesis mouse model, revealing inherent...
GARP encoded by the Lrrc32 gene is cell surface docking receptor for latent TGFβ, which expressed naturally platelets and regulatory T cells (Treg). Although amplified frequently in breast cancer, expression relevant functions of cancer have not been explored. Here, we report that exerts oncogenic effects, promoting immune tolerance enriching activating TGFβ tumor microenvironment. We found human breast, lung, colon cancers aberrantly. In genetic studies normal mammary gland epithelial...
An efficient catalytic system of a zinc cluster and tetrabutylammonium iodide (TBAI) was developed for cyclic carbonate synthesis from epoxides carbon dioxide (CO2) without the use any organic solvents under very mild conditions (25 °C, 1 atm), even in presence impurities such as water air. Electrophilicity central Zn(II) ion, number trifluoromethyl groups, nucleophilicity leaving ability anion alkylammonium salts, various reaction parameters have great effect on activity bifunctional...
Molecular chaperones control a multitude of cellular functions via folding chaperone-specific client proteins. CD4+FOXP3+ Tregs play key roles in maintaining peripheral tolerance, which is subject to regulation by multiple molecular switches, including mTOR and hypoxia-inducible factor. It not clear whether GP96 (also known as GRP94), master TLR integrin chaperone, controls Treg function. Using murine genetic models, we demonstrated that required for maintenance function, loss resulted...
Abstract The mesothelin family comprises (at least) three variants and includes the precursor for megakaryocyte potentiating factor (MPF). Assaying soluble mesothelin-related protein (SMRP) molecules in serum other body fluids from patients with certain cancers can provide diagnostically useful information. We have constructed fusion proteins of 1, 2, 3, made monoclonal antibodies, investigated binding specificity these previously generated antibodies to each variants. According flow...
Human airway epithelial cells (HAEC) constitutively express the CXC chemokine receptor CXCR3, which regulates cell movement. In diseases such as chronic obstructive pulmonary disease and asthma, characterized by denudation of lining, migration may contribute to repair reconstitution. This study compared potency efficacy three CXCR3 ligands, I-TAC/CXCL11, IP-10/CXCL10, Mig/CXCL9, inducers chemotaxis in HAEC examined underlying signaling pathways involved. Studies were performed cultured from...
Moesin is a member of the ezrin-radixin-moesin (ERM) family proteins that are important for organizing membrane domains and receptor signaling regulating migration effector T cells. Whether moesin plays any role during generation TGF-β-induced Tregs (iTregs) unknown. Here, we have discovered translationally regulated by TGF-β also required optimal promotes efficient development iTregs. Loss impaired function both peripherally derived iTregs in vitro-induced Tregs. Mechanistically, identified...
Background: Studies have shown that coagulation and fibrinolysis (CFR) are correlated with Hepatocellular carcinoma (HCC) progression prognosis. We aim to build a model based on CFR-correlated genes for risk assessment prediction of HCC patient. Methods: samples were selected from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases respectively. Molecular Signatures Database (MSigDB) was used select the CFR genes. RiskScore established by single sample gene set enrichment...
Activation of the chemokine receptor CXCR3 by its cognate ligands induces several differentiated cellular responses important to growth and migration a variety hematopoietic structural cells. In human respiratory tract, airway epithelial cells (HAEC) release Mig/CXCL9, IP-10/CXCL10, I-TAC/CXCL11. Simultaneous expression HAEC would have implications for processes inflammation repair. Accordingly, in present study we sought determine whether also express classic CXCR3-A splice variant CXCR3-B...
We recently demonstrated that human bronchial epithelial cells (HBEC) constitutively express the CXC chemokine receptor CXCR3, which when activated, induces directed cell migration. The present study in HBEC examined relative expression of CXCR3 splice variants CXCR3-A and -B, cycle dependence expression, effects ligand, interferon-γ-inducible I-TAC/CXCL11, on DNA synthesis proliferation. Both -B mRNA, assessed by real-time RT-PCR, were expressed normal (NHBEC) line 16-HBE. However, CXCR3-B...
ARDS is a heterogeneous syndrome involving different subphenotypes with clinical features and responses to treatment strategies. The prone position (PP) an effective for ARDS; however, whether the effects of positioning vary among patients remains unknown. To evaluated impact PP on ventilation-perfusion matching(VQ matching) by contrast-enhanced Electrical impedance tomography (EIT) in subphenotypes. This was prospective, observational study at medical ICU Zhongda Hospital, Southeast...
This study was conducted to investigate the possibility that TP53 mRNA is variably expressed in chronic lymphocytic leukaemia (CLL) and under-expression associated with dysfunction adverse outcome. Although levels did indeed vary among 104 CLL samples examined, this variability resulted primarily from over-expression of 18 samples, all which lacked deletion/mutation. These patients had higher lymphocyte counts shorter overall treatment-free survival times compared cases low expression no...
Abstract T-cell receptor (TCR)-mediated cross-recognition is a major mechanism in the pathogenesis of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. However, characteristics TCR repertoire clinical significance reformation throughout course DRESS are unknown. Here, we isolated CD4 + CD8 T-cells from peripheral blood 8 patients at 10-day intervals and, sequenced CDR3-regions TCRB chain by high-throughput sequencing to analyze dynamic hierarchy. Compared healthy...
Chemokine receptors control several fundamental cellular processes in both hematopoietic and structural cells, including directed cell movement, i.e., chemotaxis, differentiation, proliferation. We have previously demonstrated that CXCR3, the chemokine receptor expressed by Th1/Tc1 inflammatory cells present lung, is also human airway epithelial cells. In activation of CXCR3 induces movement proliferation, underlie lung repair. The study examined expression function alveolar type II...
Mice bearing carcinogen-induced premalignant oral lesions were previously shown to have a pro-inflammatory phenotype, which is replaced with an immune inhibitory phenotype as progress cancer. Since Th17 cells are prominent at the lesion state and their levels supported by IL-23, studies used mice that IL-23 receptor deficient (IL-23R KO) determine requirement for signaling in immunological clinical status of lesions. The results showed dependence on IL-2, IFN-γ, IL-6, IL-17 TNF-α elevated...
Most human ovarian carcinomas express mesothelin, which is shed as a diagnostically useful biomarker. We applied an ELISA to measure antibodies native mesothelin in serum from series of patients with divergent clinical outcomes. The level anti-mesothelin determined OD(450 nm) and referred absorption units (AU) for 1:20 diluted was higher who remained disease-free after therapy [no evidence disease (NED); n = 14] than whose recurred [clinical (CED); 21; P < 0.01]. Applying AU > or 0.5 at...