A5022831638- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Biliary and Gastrointestinal Fistulas
- Microfluidic and Bio-sensing Technologies
- Erythrocyte Function and Pathophysiology
- Gastrointestinal disorders and treatments
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Facial Trauma and Fracture Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ultrasound and Hyperthermia Applications
- Electrohydrodynamics and Fluid Dynamics
- Chronic Lymphocytic Leukemia Research
- Electrostatics and Colloid Interactions
Eli Lilly (United States)
2025
East Carolina University
2024
University Medical Center
2024
National Taiwan University
2023
Loxo Oncology at Lilly (United States)
2023
Johns Hopkins Medicine
2020-2021
Johns Hopkins Hospital
2021
Boston University
2021
University of Washington
2010-2021
University of Michigan
1997-2021
Polysaccharide krestin (PSK) is a mushroom extract that has been long used in Asia and recently Western countries as treatment for cancer due to its presumed immune potentiating effects. Although there have reports of clinical responses after patients ingested PSK, the mechanism action agent remains undefined. The current study was undertaken investigate antitumor actions PSK.The immunostimulatory effect PSK first evaluated vitro using splenocytes from neu transgenic mice Toll-like receptor...
Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the barrier could both increase permeabilize tumor, enhancing penetration. Mechanical disruption of stroma can be achieved using ultrasound-induced bubble activity-cavitation. Cavitation also known to result in microstreaming have added benefit actively diffusion into tumors. Here, we report ability enhance chemotherapeutic drug doxorubicin...
Abstract Multiple TLR agonists have been shown to antitumor effects in animal models. However, the therapeutic efficacy of agonist monotherapy cancer treatment has limited, and mechanisms failure remain unknown. We demonstrate that topical with a TLR-7 agonist, imiquimod, can elicit significant regression spontaneous breast cancers neu transgenic mice, model human HER-2/neu+ cancer. tumor growth progressed once imiquimod therapy was ended. Gene expression analysis using tumor-derived RNA...
The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate just 8%. Here, we evaluate the ability enhance targeted drug delivery using mild hyperthermia in combination with systemic administration low-temperature sensitive liposomal formulation doxorubicin (LTSL-Dox) relevant model pancreas cancer.Experiments were performed genetically engineered mouse (KPC mice: LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre). LTSL-Dox or free (Dox) was administered via...
TPS900 Background: Nectin-4 is a cell surface antigen overexpressed in multiple tumor types including urothelial cancer. Enfortumab vedotin (EV) first generation anti-nectin-4 antibody-drug conjugate (ADC) comprising fully humanized antibody conjugated to an MMAE payload with heterogeneous DAR 4 and approved metastatic carcinoma (mUC) both as single agent treatment refractory disease first-line combination pembrolizumab. Persistent nectin-4 expression despite progression on EV has been...
Abstract Background: SMARCA4 (BRG1) alterations occur in ∼7% and 10% of all solid tumors NSCLC, respectively, are associated with worse overall survival.1, 2 mutations create a dependency on SMARCA2 (BRM), resulting synthetic lethality when is selectively inhibited.3 LY4050784 an oral, potent, selective inhibitor that has demonstrated robust single-agent tumor regressions across multiple murine xenograft models SMARCA4-mutated NSCLC.4 Methods: This first-in-human, phase 1a/b open-label,...
OBJECTIVE: To compare pharmacy students' acquired knowledge and ability to assess metered-dose inhaler (MDI) technique after a traditional lecture versus Web-based MDI tutorial. METHODS: All 42 third-year PharmD students completed baseline test were then randomized into 1 of 3 groups. The Web group the tutorial on college dispensing laboratory computers; participated in excerpt asthma therapeutics lecture; control 15-minute discussion participants' hobbies. Afterward, participants each an...
Objective To evaluate the treatment, outcome, and prognostic factors in patients with head neck sarcomas treated an academic medical center. Study Design Case series. Setting Academic Subjects Methods We performed a retrospective analysis of adult (n = 97) primary between 2000 2012. analyzed potential predictive disease‐free survival disease‐specific survival. also evaluated outcome bone soft tissue sarcomas. Results The median overall was 6.8 years, 2‐year 5‐year rates 78% (95% confidence...
TPS7583 Background: Covalent (c) Bruton tyrosine kinase inhibitors (BTKi) have reshaped the treatment landscape for chronic lymphocytic leukemia/small lymphoma (CLL/SLL) and are now often used as initial therapy. The MURANO study established 2-year fixed duration venetoclax plus rituximab a standard of care regimen patients with relapsed or refractory CLL/SLL. However, its efficacy has not been formally assessed in CLL/SLL treated cBTKi, common setting where this is contemporary practice....
Naso-orbitoethmoid fractures associated with ipsilateral zygomaticomaxillary complex are more challenging injuries than alone. However, there is a paucity of information on this fracture pattern in the pediatric population. This study investigated cause, treatment, and outcomes combined naso-orbitoethmoid versus isolated patients.This was 25-year retrospective cohort patients who presented to single institution fractures. Baseline patient demographics clinical information, concomitant...
Electrophoresis of a dielectric fluid droplet with constant surface charge density is investigated theoretically in this study. A pseudo-spectral method based on Chebyshev polynomials adopted to solve the governing electrokinetic equations. It found, among other things, that larger electrolyte strength ambient solution is, slower moves general. This due strong screening effect large amount indifferent counterions neighborhood droplet, no reinforcement potential-determining ions adsorbing...
Gastrointestinal stromal tumors are the most common mesenchymal of gastrointestinal tract. The introduction a number small molecule tyrosine kinase inhibitors has revolutionized management metastatic disease. Surgery is mainstay for localized Patients with high risk treated adjuvant imatinib. We report rare presentation primary bowel tumor in association multiple liver abscesses. Cystic lesions should be fully evaluated gastro intestinal patients to exclude an infective cause. Treatment...
Diffusiophoresis of a weakly charged liquid metal droplet (LMD) is investigated theoretically, motivated by its potential application in drug delivery. A general analytical formula valid for condition adopted to explore the phoretic behavior. We determined that droplet, which special category conducting general, always moves up along chemical gradient sole chemiphoresis, contrary dielectric where tends move down most time. This suggests therapeutic nanomedicine such as gallium LMD inherently...