A5100457633- Lipid metabolism and disorders
- Bioactive Natural Diterpenoids Research
- Natural product bioactivities and synthesis
- Drug Transport and Resistance Mechanisms
- Plant-derived Lignans Synthesis and Bioactivity
- Electromagnetic Fields and Biological Effects
- Retinoids in leukemia and cellular processes
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Kruppel-like factors research
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Hops Chemistry and Applications
- Cancer Cells and Metastasis
- Bioactive natural compounds
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- ATP Synthase and ATPases Research
- Adipose Tissue and Metabolism
Wenzhou Medical University
2021-2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Beijing University of Chinese Medicine
2021
First Hospital of China Medical University
2019
China Medical University
2019
General Hospital of Guangzhou Military Command
2013
Harbin Medical University
2009
Abstract Osteoarthritis (OA) is a complex condition that involves both apoptosis and senescence currently cannot be cured. Fibroblast growth factor 21 (FGF21), known for its role as potent regulator of glucose energy metabolism, protects from various diseases, possibly by mediating autophagy. In the present study, FGF21 in progression OA was investigated vitro vivo experiments. vitro, results revealed administration alleviated apoptosis, senescence, extracellular matrix (ECM) catabolism...
Objectives: To investigate the anticancer effect and potential mechanism of combination treatment with arsenic trioxide (ATO) parthenolide (PTL) in human pancreatic cancer cells. Methods: The effects PTL/ATO on 2 carcinoma cell lines, PANC-1 BxPC-3, were determined by trypan blue exclusion, annexin V/propidium iodide, 4′,6-diamidino-2-phenylindole HCl, terminal deoxynucleotidyltransferase-mediated nick-end labeling, flow cytometry, Western blot, clonogenic assay. In vivo study was performed...
Osteoarthritis (OA) is a frequently observed condition in aged people. OA cartilage characterized by chondrocyte apoptosis, inflammation, and hyperactive catabolism of extracellular matrix. However, the specific molecular mechanisms remain unclear. Recent data has shown that Angptl4, multifunctional cytokine, involved regulation inflammatory apoptosis responses different tissues. This study aimed at defining role Angptl4 development OA. We employed X-ray analysis, safranin O-fast green (S-O)...
Gastric cancer (GC) is one of the most common malignancies and has second highest lethal rate in world; thus, finding new medicines with high potency low toxicity urgent. Cudrania tricuspidata (Carr.) Bur. ex Lavallee (Moraceae) a traditional medicinal herb that considered to have antitumour efficacy. We extracted isolated cudraxanthone L (CXL) from evaluated its anti-cancer CXL treatment inhibited angiogenesis chorioallantoic membrane (CAM) repressed cell viability various human cells,...
Cancer side population (SP) cells with cancer stem cell-like properties are thought to be responsible for lung chemotherapy resistance and currently no drug can efficiently target them. Breast protein (BRCP/ABCG2) is a major transporter in protecting SP from cytotoxic agents. We showed that low concentration of ethanol, which inhibits many membrane proteins, ABCG2 cells. Furthermore, cisplatin (DDP) 5% (vol/vol) ethanol kills plus non-SP better than either treatment alone eradicating...