A5070741852- Health Literacy and Information Accessibility
- Media, Religion, Digital Communication
- Religion, Spirituality, and Psychology
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Mental Health via Writing
- Polymer Surface Interaction Studies
- Social Media and Politics
- Gout, Hyperuricemia, Uric Acid
- Digital Communication and Language
- Mental Health Research Topics
- Knowledge Management and Sharing
- Digital Mental Health Interventions
- Sentiment Analysis and Opinion Mining
- Expert finding and Q&A systems
- Pharmacological Effects of Medicinal Plants
- Autophagy in Disease and Therapy
- Power Systems Fault Detection
- Phytase and its Applications
- Antimicrobial agents and applications
- Innovative Human-Technology Interaction
- Thermal Regulation in Medicine
- Spondyloarthritis Studies and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Extracellular vesicles in disease
Wenzhou Medical University
2020-2024
Lishui Central Hospital
2023-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2023
State Grid Corporation of China (China)
2022
University of Minnesota
2016-2021
University of Minnesota System
2020
Twin Cities Orthopedics
2016
Abstract Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease accompanied by complex pathophysiological mechanisms. Increasing evidence indicates that NLRP3 inflammasome mediated pyroptosis of nucleus pulposus (NP) cells displays an important role in the pathological progression IVDD. Milk fat globule-EGF factor-8 (MFG-E8) endogenously secreted glycoprotein with beneficial effects anti-inflammatory, antioxidant, and modulation inflammasome. However, effect...
Background: Caloric restriction mimetics (CRMs) mimic the favourable effects of caloric (CR) and have been shown to therapeutic in neuroinflammatory disease. However, whether CRMs improve functional recovery from spinal cord injury (SCI) underlying mechanism action remain unclear. In this study, we used 3,4-dimethoxychalcone (3,4-DC) evaluate value for SCI. Methods: HE, Masson Nissl staining; footprint analysis; Basso mouse scale were determine SCI after 3,4-DC treatment. RNA sequencing was...
As the third most popular social network among millennials, Snapchat is well known for its picture and video messaging system that deletes content after it viewed. However, Stories feature of offers a different perspective ephemeral sharing, with pictures videos are available friends to watch an unlimited number times 24 hours. We conduct-ed in-depth qualitative investigation by interviewing 18 participants reviewing 14 days their posts. identify five themes focused on how perceive use...
Glucocorticoids (GCs) overuse is associated with decreased bone mass and osseous vasculature destruction, leading to severe osteoporosis. Platelet lysates (PL) as a pool of growth factors (GFs) were widely used in local repair by its potent pro-regeneration pro-angiogenesis. However, it still seldom applied for treating systemic osteopathia due the lack suitable delivery strategy. The non-targeted distribution GFs might cause tumorigenesis other organs. In this study, PL-derived exosomes...
Expressive writing has been shown to improve physical, mental, and social health outcomes for patients struggling with difficult diagnoses. In many online communities, comprises a substantial portion of the user experience, yet little work explored how itself affects engagement. This paper explores engagement on CaringBridge, prominent community about personal journeys. We build survival analysis model, defining new set variables that operationalize expressive writing, comparing these...
Instrumental support is critical for patients and family caregivers facing life-threatening illnesses, injuries, or chronic conditions (e.g., cancer). We partner with CaringBridge.org—a prominent online health community journaling about crises—to conduct a study of instrumental in the following two phases: content analysis 641 journal updates; survey 991 users. Quantitative results show that: (1) prefer to receive different types than their care networks provide; (2) people generally have...
IL-1β promotes inflammatory response and extracellular matrix (ECM) degradation through NF-κB signaling pathway; while cardamonin attenuates the ECM by suppressing pathway<italic>via</italic>Nrf2/HO-1 axis.
Multiterritory perforator flap survival is commonly applied in surgical tissue reconstructions and covering of large skin defects. However, multiple risk factors such as ischemia, reperfusion injury apoptosis after reconstructive surgeries cause necrosis distal parts with outcomes ranging from poor aesthetic appearance to failure. A few studies have reported that sitagliptin promotes angiogenesis inhibits apoptosis. little known about sitagliptin-induced autophagy especially on the model....
Osteoarthritis (OA) is a frequently observed condition in aged people. OA cartilage characterized by chondrocyte apoptosis, inflammation, and hyperactive catabolism of extracellular matrix. However, the specific molecular mechanisms remain unclear. Recent data has shown that Angptl4, multifunctional cytokine, involved regulation inflammatory apoptosis responses different tissues. This study aimed at defining role Angptl4 development OA. We employed X-ray analysis, safranin O-fast green (S-O)...
Projector-camera (pro-cam) systems create virtual environments for remote interaction with audio and video support. However, previous pro-cam require custom hardware thus have not been used at-scale in the field. In this work, we present a application to reinforce social relationships an off-the-shelf system. The ShareTable users can use chat conjunction sharing tabletop video, allowing them connect while playing interacting together.
Spinal cord injury (SCI) is a clinical tough neurological problem without efficient cure currently. Blood-spinal barrier (BSCB) interruption not only crucial pathological feature for SCI process but possible target future treatments; however, few treatments have been developed to intervene BSCB. In the present study, we intravenously injected CO-releasing molecule3 (CORM-3), classical exogenous CO donor, rats experiencing and assessed its protection on BSCB integrity in rats. Our results...
Abstract Abnormal lipid metabolism, such as systemic increased free fatty acid, results in overproduction of pro‐inflammatory enzymes and cytokines, which is crucial the development obesity‐related osteoarthritis (OA). However, there are only a few drugs that target lipotoxicity OA. Recent researches have documented traditional Chinese medicine, Sparstolonin B (Ssn B), exerted anti‐inflammatory effects various diseases, but not yet On basis this evidence, our works purposed to evaluate...
Multiterritory perforator flap is an important plastic surgery technique, yet its efficacy can be limited by partial necrosis at the choke Ⅱ zone. Butylphthalide (NBP) has been used for many diseases but not studied in multiterritory flap. With effect of NBP, we observed increasing capillary density, inhibition autophagy and oxidative stress, a reduction apoptosis cells, all consistent with increased survival. However, protective NBP on was lost following administration agonist rapamycin...
Aiming at the problems that result of grounding line selection is unsatisfactory and reliability difficult to make quantitative analysis fault identification method for distribution with neutral point through arc extinguishing coil, a based on zero-mode transient information modified ensemble empirical mode decomposition proposed. Firstly, this paper utilized extract information, because direction in opposite non-fault during transient. Then, extracted signals were decomposed by MEEMD HHT...
Online platforms provide new channels for people in need to seek help from friends and strangers. However, individuals often encounter psychological barriers that deter them asking help. For example, might have different concerns about help, including acknowledging incompetence, bothering others, accruing social debt. These perceived costs limit the potential benefits of solicitations. In this study, we attempt investigate whether anonymity (posting a question anonymously), ephemerality...
Although expressive writing has proved to be beneficial on physical, mental, and social health of individuals, it been restrained lab-based experimental studies. In the real world, individuals may naturally engage with when dealing difficult times, especially facing a tough journey. Health blogging serve as an easy-to-access method for self-therapy, if spontaneous occurs. However, many posts not enough provide therapeutic power. this study, we build Gaussian naive Bayes model detect in...