A5101977033- Pulmonary Hypertension Research and Treatments
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Aortic Disease and Treatment Approaches
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Cardiomyopathy and Myosin Studies
- Nutritional Studies and Diet
- Cardiovascular Issues in Pregnancy
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Glioma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Antioxidant Activity and Oxidative Stress
- Aortic aneurysm repair treatments
- Robotic Locomotion and Control
- RNA Interference and Gene Delivery
Fudan University Shanghai Cancer Center
2022-2025
Shanghai Medical College of Fudan University
2025
Shandong University of Traditional Chinese Medicine
2024
Ningbo Medical Center Lihuili Hospital
2024
Weatherford College
2024
Second Affiliated Hospital of Jilin University
2021-2024
Affiliated Hospital of Nantong University
2014-2024
Nantong University
2014-2024
University of Electronic Science and Technology of China
2024
Beijing Institute of Technology
2023-2024
Indigenous Tibetan people have lived on the Plateau for millennia. There is a long-standing question about genetic basis of high-altitude adaptation in Tibetans. We conduct genome-wide study 7.3 million genotyped and imputed SNPs 3,008 Tibetans 7,287 non-Tibetan individuals Eastern Asian ancestry. Using this large dataset, we detect signals at nine genomic loci, which seven are unique. The alleles under natural selection two these loci [methylenetetrahydrofolate reductase (MTHFR) EPAS1]...
Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but their ability to recognize disease tissue and further achieve synergistic regulation has rarely been studied. Herein, Arginylglycylaspartic acid (RGD)-modified Distearyl acylphosphatidyl ethanolamine (DSPE)-polyethylene glycol (PEG) (DSPE-PEG-RGD) micelle is prepared with a DSPE hydrophobic core load the photothermal therapy (PTT) dye IR780 calcium efflux pump inhibitor curcumin. Then, MNAzyme distributed into...
The metal-nucleic acid nanocomposites, first termed frameworks (MNFs) in this work, show extraordinary potential as functional nanomaterials. However, thus far, realized MNFs face limitations including harsh synthesis conditions, instability, and non-targeting. Herein, we discover that longer oligonucleotides can enhance the efficiency stability of by increasing oligonucleotide folding entanglement probabilities during reaction. Besides, provide upgraded metal ions binding facilitating to...
Corin is a transmembrane protease that processes natriuretic peptides in the heart. Like many membrane proteins, corin shed from cell surface.In this study, we obtained plasma samples healthy controls and patients with heart failure (HF) acute myocardial infarction. Soluble levels were measured by an ELISA method. In adults (n=198), 690 pg/mL (SD, 260 pg/mL). The did not differ significantly among different age groups. HF (n=291), lower compared of (365 [SD, 259]; P<0.001). reduction seemed...
Background There is growing evidence that antioxidant-rich diets may prevent hyperlipidemia. However, the relationship between Composite Dietary Antioxidant Index (CDAI) and hyperlipidemia unclear. The CDAI a composite score reflecting antioxidant content of an individual’s diet, this study aimed to investigate Methods used 2003–2018 National Health Nutrition Examination Survey (NHANES) database for cross-sectional analyses included 27,626 participants aged 20 years older. CDAI, which...
Objective To examine the association between weight-adjusted waist index (WWI) and odds of type 2 diabetes mellitus(T2DM)among U.S. adults. Methods Data from National Health Nutrition Examination Survey (NHANES) spanning six years (2007–2018) were utilized, encompassing 31001 eligible participants. Weighted multivariate logistic regression models smoothed fit curves employed to assess WWI T2DM, as well dose-response relationships in overall population T2DM various subgroups. Results In fully...
Pillarenes and calixarenes showed obvious inhibition of HPV16 L1 pentamer formation via their selective binding to Arg Lys residues at the monomer interface, which was reversible after release cyclic arenes. are more effective than in terms efficiency, attributing different kinetics affinity.
Targeted theranostic platform that integrates multi-modal imaging and therapeutic function is emerging as a promising strategy for earlier detection precise treatment of cancer. Herein, we designed targeted gold-nanoshelled poly (lactic-co-glycolic acid) (PLGA) magnetic hybrid nanoparticles carrying anti-human epidermal growth factor receptor 2 (Her2) antibodies (Her2-GPH NPs) dual-modal ultrasound (US)/magnetic resonance (MR) photothermal therapy breast The agent was fabricated by coating...
In clinical practice, we noticed that triple negative breast cancer (TNBC) patients had higher shear-wave elasticity (SWE) stiffness than non-TNBC and a α-SMA expression was found in TNBC tissues the tissues. Moreover, SWE also shows clear correlation to neoadjuvant response efficiency. To elaborate this phenomenon, cell membrane-modified polylactide acid-glycolic acid (PLGA) nanoparticle fabricated specifically deliver artesunate regulate through inhibiting CAFs functional status. As tested...
The treatment of breast cancer is often ineffective due to the protection tumor microenvironment and low immunogenicity cells, leading a poor therapeutic effect. In this study, we designed nano-theranostic platform for these obstacles: photothermal effect mediated by gold shell could remodel decreasing cancer-associated fibroblasts (CAFs) promote release doxorubicin (DOX) from nanoparticles. addition, it realize photoacoustic (PA)/MRI dual-model imaging diagnose targeted identification...
Triple-negative breast cancer (TNBC) is highly malignant, with rapid tumor growth and metastasis. Due to ER-, PR- HER2-of TNBC, FGFR pathway play a pivotal role in the progression of TNBC. Its ligand FGFs mostly released from extracellular matrix by fibroblast factor binding protein 1 (FGFBP1). However, little known about FGFBP1 In this study, we found that overexpression significantly promoted proliferation, migration invasion TNBC cells vitro vivo vice versa. Mechanistically, upregulated...
In the clinical setting, efficacy of single-agent immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) remains suboptimal. Therefore, there is a pressing need to develop predictive biomarkers identify non-responders. Considering that cancer-associated fibroblasts (CAFs) represent an integral component tumor microenvironment affects stiffness solid tumors on shear-wave elastography (SWE) imaging, wound healing CAFs (WH CAFs) were identified highly heterogeneous TNBC....
Hypoxia-inducible factor-1 (HIF-1) is a critical transcription factor that regulates the expression of genes involved in cellular adaptation to low oxygen levels. Aberrant regulation HIF-1 signaling pathway linked various human diseases. Previous studies have established HIF-1α rapidly degraded von Hippel-Lindau protein (pVHL)-dependent manner under normoxic conditions. In this study, we find pVHL binding 1 (VBP1) negative regulator but not HIF-2α using zebrafish as an vivo model and vitro...
To screen immune-related prognostic biomarkers in low-grade glioma (LGG), and reveal the potential regulatory mechanism. The differential expressed genes (DEGs) between alive dead patients were initially identified, then key common DEGs obtained. Regarding associated with overall survival (OS), their clinical value was assessed by Kaplan–Meier, RCS, logistic regression, ROC, decision curve analysis methods. We also role of immune infiltration on association OS. All analyses based TGCA-LGG...