A5031625617- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Circular RNAs in diseases
- Tree-ring climate responses
- Plant Water Relations and Carbon Dynamics
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Cardiac tumors and thrombi
- Coronary Artery Anomalies
- Infectious Aortic and Vascular Conditions
- Cancer-related molecular mechanisms research
- Ergonomics and Musculoskeletal Disorders
- RNA Interference and Gene Delivery
- Cardiovascular Issues in Pregnancy
- Advanced Vision and Imaging
- Forest ecology and management
- Congenital heart defects research
- Kawasaki Disease and Coronary Complications
- Ecology and Vegetation Dynamics Studies
- Geophysical and Geoelectrical Methods
- Macrophage Migration Inhibitory Factor
Second Affiliated Hospital of Jilin University
2016-2025
Northeast Agricultural University
2010-2025
Hunan University
2022-2025
Education Department of Heilongjiang Province
2024-2025
Great Wall Motors (China)
2024
China Meteorological Administration
2022-2024
Xinjiang Institute of Ecology and Geography
2023-2024
First Bethune Hospital of Jilin University
2015-2023
Jilin University
2014-2020
China University of Mining and Technology
2020
Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method therapy. In this study we demonstrate the role growth differentiating factor 15 (GDF15) in septic AKI using a murine lipopolysaccharide (LPS)-induced sepsis model an vitro cell culture system. Data show that GDF15 deficiency augments inflammatory response exacerbates renal cardiac induced by LPS, while over-expression protects heart from LPS-induced organ dysfunction....
Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles signaling remain largely unknown. It unclear GDF15-DCs can induce immune tolerance heart transplantation (HT). This study aims to understand the impact of endogenous on DC's development, function, underlying molecular mechanism including circular RNA (circRNA). will also explore GDF15-DC-mediated modulation HT. Bone marrow (BM) derived...
This study examines the application of onboard Internet Things (IoT) technology in intelligent automotive industry, particularly integration Environmental, Social, and Governance (ESG) principles with IoT importance mandatory standardization. The research initially analyzes current development its applications smart sector, highlighting potential to enhance road safety, increase energy efficiency, improve user experience. Subsequently, paper discusses necessity incorporating ESG into...
Abstract This paper presents the investigations into feasibility of application a remediation system that couples electrokinetic (EKR) with permeable reactive barrier (PRB) concept for municipal solid waste incineration (MSWI) fly ash activated charcoal as PRB material. The experimental results this study showed proposed combined method can effectively improve efficiency and addition oxalic acid to media before coupled further enhance process. In optimization tests, maximum removals Zn, Pb,...
Heart transplant has been accepted as the standard treatment for end-stage heart failure. Because of its susceptibility to ischemia–reperfusion injury, can be preserved only 4 6 hours in cold static preservation solutions. Prolonged ischemia time is adversely associated with primary graft function and long-term survival. New strategies preserve donor hearts are urgently needed. We demonstrate that AP39, a mitochondria-targeting hydrogen sulfide donor, significantly increases cardiomyocyte...
// Yixin Zhang 1, 2 , Lisa A. Moszczynski Qing Liu 1 Jifu Jiang Duo Zhao Douglas Quan 3, 4, 5 Tina Mele Vivian McAlister Anthony Jevnikar 5, 6, 7 Seung Joon Baek 8 Kexiang and Xiufen Zheng 2, Department of Cardiovascular Surgery, The Second Hospital, Jilin University, Changchun, China Pathology, Western Ontario, Canada 3 4 Lawson Health Research Institute, London Sciences Centre, 6 Medicine, Matthew Mailing Biomedical Diagnostic Sciences, College Veterinary University Tennessee, Knoxville,...
Bisphenol A (BPA) is a common endocrine disruptor chemical that widely used in the production of food plastic packaging, and it has been shown to potentially harm reproductive system. However, specific mechanism by which BPA induces apoptosis Leydig cells (LCs) inhibits testosterone synthesis these unclear. In present study, TM3 were as an experimental model combination with reactive oxygen species (ROS) scavenger (N-acetylcysteine), Caspase-3 inhibitor (Ac-DEVD-CHO), autophagy activator...
Bisphenol A (BPA), a widely used chemical compound in plastic manufacturing, has become ubiquitous the environment. Previous studies have highlighted its adverse effects on reproductive function, as BPA exposure reduces testosterone levels. Cholesterol is involved synthesis Leydig cells. However, research mechanisms by which affects from perspective of reverse cholesterol transport (RCT) remains limited. This study aimed to investigate levels, lipid droplet accumulation, and TM3 cells mice...
3D scanning capture complex ear morphology, but most research focuses on dimensions defined by product design or ergonomic guidelines, often missing crucial details, especially those of canal for in-ear design. This study conducted a statistical shape analysis the geometry cavum concha and external auditory meatus (EAM) using 1195 scans Chinese ears. A surface registration method was adopted to standardise align models analysis. Principal component (PCA) generated shapes, with significant...
Ischemic heart disease still remains the most common cause of cardiac death. During ischemia-reperfusion (I/R), reactive oxygen species (ROS) are produced in excess tissue, where they induce cell Our previous study showed that 9-phenanthrol (9-Phe), a specific inhibitor TRPM4 channel, preserves contractile function and protects from I/R injury-related infarction excised rat heart. Accordingly, we hypothesized channels involved 9-Phe-mediated cardioprotection against ROS-induced injury. In...
The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. aim this study was to investigate whether Pte modulates neutrophil accumulation and the induction tumor necrosis factor-α (TNF‑α) an (I/R)‑injured rat heart model. Rats were randomly exposed a sham operation, myocardial (MI/R) alone, MI/R+Pte, MI/R+Pte+L‑NAME MI/R+Pte+ (methylene blue) MB. results demonstrated that compared with MI/R, reduced area infarction, levels myeloperoxidase, serum...
Circular RNAs (circRNAs) are genetic regulators that were earlier considered as "junk". In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act RNA-binding proteins, sequestering agents, transcriptional regulators, well microRNA sponges. addition, it is reported some selected circRNAs transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species....
Ischemia-reperfusion (I/R) injury occurring in heart transplantation (HT) remains as a leading cause of transplant graft failure. Circular RNAs (circRNAs) play important roles gene regulation and diseases. However, the impact circRNAs on I/R during HT unknown. This study aims to investigate role circular RNA Foxo3 (circFoxo3) HT. Using an vivo mouse model vitro cardiomyocyte culture model, we demonstrated that circFoxo3 is significantly upregulated I/R-injured hearts hypoxia/reoxygenation...
Selenium (Se), an antioxidant agent, provides significant protection from reactive oxygen species (ROS)-induced cell damage in vivo and vitro. However, it is unclear whether Se can protect against zearalenone (ZEN)-induced apoptosis chicken spleen lymphocyte. In this study, we investigated the underlying mechanism of induced by ZEN lymphocyte further evaluated protective on ZEN-induced apoptosis. The results show that increase ROS generation lipid peroxidation, a decrease levels superoxide...