A5100351202- Migraine and Headache Studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Reconstructive Surgery and Microvascular Techniques
- Ophthalmology and Eye Disorders
- Traditional Chinese Medicine Analysis
- Oral microbiology and periodontitis research
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Trigeminal Neuralgia and Treatments
- Cancer, Lipids, and Metabolism
- Reconstructive Facial Surgery Techniques
- Pulmonary Hypertension Research and Treatments
- Protein Degradation and Inhibitors
- FOXO transcription factor regulation
- Bone fractures and treatments
- Wound Healing and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Pain Mechanisms and Treatments
- Chronic Myeloid Leukemia Treatments
- Pancreatic and Hepatic Oncology Research
Peking University
2021-2025
National Clinical Research Center for Digestive Diseases
2018-2025
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2025
Hebei University of Chinese Medicine
2019-2025
Herzen University
2025
Sichuan University
2017-2025
Hebei Science and Technology Department
2022-2025
Second Affiliated Hospital of Shantou University Medical College
2025
Shantou University
2025
The detection of nonsmall cell lung cancer (NSCLC) at an early stage presents a daunting challenge due to the lack specific noninvasive marker. discovery microRNAs (miRNAs), particularly those found in serum, has opened new avenue for tumor diagnosis. To determine whether expression profile serum miRNAs can serve as NSCLC fingerprint, we performed Taqman probe-based quantitative RT-PCR assay selected differentially expressed from sample set including 400 cases and 220 controls, risk score...
Central sensitization is an important mechanism of chronic migraine (CM) and related to the inflammatory response microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate process microglia in several neurological diseases, but its role CM largely unknown. Therefore, aim this study was identify precise microglial NLRP3 CM. An experimental mouse model established by repeated intraperitoneal (i.p) injection with nitroglycerin (NTG). We evaluated expression levels downstream...
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) HLA-DQ (rs2856718 rs7453920) were associated with chronic hepatitis B virus (HBV) infection Japanese populations. More than 75% of hepatocellular carcinoma (HCC) patients are attributable to persistent (HBV), especially China. We genotyped these SNPs 1,300 HBV-positive HCC patients, 1,344 HBV carriers, persons natural clearance from...
Background Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development progression. However, genetic variations the lncRNAs their associations with HCC susceptibility not been reported. In this study, we hypothesized single nucleotide polymorphisms (SNPs) MALAT1 contribute to risk. Methods We conducted a case-control study genotyped SNPs, rs7763881 rs619586 1300 HBV positive patients, 1344...
Microglial activation contributes to the development of chronic migraine (CM). The P2Y12 receptor (P2Y12R), a metabolic purinoceptor that is expressed on microglia in central nervous system (CNS), has been indicated play critical role pathogenesis pain. However, whether it mechanism CM remains unknown. Thus, present study investigated precise details microglial P2Y12R involvement CM.Mice subjected recurrent nitroglycerin (NTG) treatment were used as model. Hyperalgesia assessed by mechanical...
Background: Sepsis-induced cardiomyopathy (SIC) is a severe myocardial dysfunction secondary to septicemia. It major concern owing the high mortality and morbidity, which are greatly influenced by ferroptosis. Resveratrol (RSV) naturally existing agonist of silent information regulator 1 (Sirt1). has cardioprotective effects against sepsis-induced injury, However, detailed mechanism unknown.Methods: In this study, cecal ligation puncture (CLP)-induced septic rats were employed assess changes...
Piezo1 channels are mechanosensitive cationic that activated by mechanical stretch or shear stress. Endothelial activation stress caused blood flow induces ATP release from endothelial cells; however, the link between and production is unclear.The mitochondrial respiratory function of cells was measured using high-resolution respirometry system Oxygraph-2k. The intracellular Ca2+ concentration evaluated Fluo-4/AM Rhod-2/AM.The specific channel activator Yoda1 its analogue Dooku1 increased...
Sepsis is a systemic inflammatory response syndrome caused by infection, which causes renal dysfunction known as sepsis-associated acute kidney injury (S-AKI). Ferroptosis form of lipid peroxidation dependent on iron and reactive oxygen species that differs from other forms programmed cell death at the morphological biochemical levels. Andrographolide (AG), natural diterpenoid lactone compound extracted Andrographis paniculata, has been shown to have therapeutic effects in disease. In this...
Objectives This study explored the clinical characteristics of vestibular migraine in Chinese subjects and performed a field test criteria International Classification Headache Disorders 3rd edition beta version. Methods Consecutive patients with were surveyed registered headache clinic during period. The diagnosis was made according to Assessments included standardized neuro-otology bedside examination, pure-tone audiogram, bithermal caloric testing, neurological imaging, cervical X-ray or...
Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality with no accepted method therapy. In this study we demonstrate the role growth differentiating factor 15 (GDF15) in septic AKI using a murine lipopolysaccharide (LPS)-induced sepsis model an vitro cell culture system. Data show that GDF15 deficiency augments inflammatory response exacerbates renal cardiac induced by LPS, while over-expression protects heart from LPS-induced organ dysfunction....
The mechanism underlying migraine chronification remains unclear. Central sensitization may account for this progression. microglia P2X4 receptor (P2X4R) plays a pivotal role in the central of inflammatory and neuropathic pain, but there is no information about P2X4R migraine. Therefore, aim study was to identify precise chronic (CM).We used an animal model with recurrent intermittent administration nitroglycerin (NTG), which closely mimics CM. NTG-induced basal acute mechanical...
Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles signaling remain largely unknown. It unclear GDF15-DCs can induce immune tolerance heart transplantation (HT). This study aims to understand the impact of endogenous on DC's development, function, underlying molecular mechanism including circular RNA (circRNA). will also explore GDF15-DC-mediated modulation HT. Bone marrow (BM) derived...
Abstract Background Central sensitization is an important pathophysiological mechanism of chronic migraine (CM). According to our previous studies, microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute central sensitization. The P2X7 receptor (P2X7R) a purinergic expressed microglia participates pain, but its role CM unclear. Numerous studies have shown that P2X7R regulates level autophagy affects inflammation. Recently, has been be involved...
Streptococcus mutans (S. mutans) is a potential pathogenic bacteria of dental caries. However, the level S. low in some children with severe early childhood caries (SECC).To evaluate effect on microbiome and cariogenesis.The oral microbiota was compared between caries-free group (CF) SECC group.16S rRNA gene sequencing used for bacterial community analysis. The candidate that were closely related abundance identified confirmed by absolute quantitative real-time PCR clinical plaque samples...
Vestibular symptoms are frequently reported in patients with chronic migraine (CM). However, whether vestibular arise through overlapping neurobiology of remains to be elucidated. The neuropeptide calcitonin gene-related peptide (CGRP) and CGRP1 receptor play important pathological roles facilitating central sensitization CM. Therefore, we aimed investigate contributes dysfunction after CM by improving synaptic transmission the nucleus (VN).A rat model was established recurrent intermittent...
Lipid metabolism disorders are a prominent characteristic in the pathological development of non-alcoholic fatty liver disease (NAFLD). Danshen zexie decoction (DZD) is Chinese herbal medicine that based on and has an effect regulating lipid mechanism. However, anti-NAFLD mechanism DZD remain unclear. In this study, we observed therapeutic NAFLD rats investigated its possible mechanisms. Sixty Sprague Dawley were randomly assigned to six groups: control group, model Yishanfu (polyene...
Tyrosine kinase inhibitors (TKIs) have emerged as the first-line small molecule drugs in many cancer therapies, exerting their effects by impeding aberrant cell growth and proliferation through modulation of tyrosine kinase-mediated signaling pathways. However, there exists a substantial inter-individual variability concentrations certain TKIs metabolites, which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious...
Macrophages are involved mainly in the balance between inflammation and tenogenesis during healing process of tendinopathy. However, etiological therapeutic strategies to efficiently treat tendinopathy by modulating macrophage state still lacking. In this study, we find that a small molecule compound Parishin-A (PA) isolated from Gastrodia elata could promote anti-inflammatory M2 polarization inhibiting gene transcription protein phosphorylation signal transducers activators 1. Local...
Background MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles diverse processes including immune response and tumorigenesis. A single nucleotide polymorphism (SNP), rs999885, is located the promoter region MCM7. Methods We performed a case-control study 1300 HBV-positive hepatocellular carcinoma (HCC) cases, 1344 HBV persistent carriers subjects with natural clearance to test association between rs999885 risk infection HCC. also investigated genotype-expression...
Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little known about its role inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. Here, we determined contributions P2X4R and related signaling pathways an model. Methods gene protein levels nucleus caudalis were analyzed repeated dural soup infusions. p38,...