A5050221917- Neonatal and fetal brain pathology
- Virus-based gene therapy research
- Intracerebral and Subarachnoid Hemorrhage Research
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Intracranial Aneurysms: Treatment and Complications
- Biomarkers in Disease Mechanisms
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Apelin-related biomedical research
- S100 Proteins and Annexins
- Kruppel-like factors research
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Traditional Chinese Medicine Analysis
- Neurosurgical Procedures and Complications
Zhujiang Hospital
2016-2025
Southern Medical University
2016-2025
Loma Linda University
2017-2024
Nanfang Hospital
2023
Czech Academy of Sciences, Institute of Physiology
2018
Sodium butyrate, a short-chain fatty acid, is predominantly produced by gut microbiota fermentation of dietary fiber and serves as an important neuromodulator in the central nervous system. Recent experimental evidence has suggested that sodium butyrate may be endogenous ligand for two orphan G protein-coupled receptors, GPR41 GP43, which regulate apoptosis inflammation ischemia-related pathologies, including stroke. In present study, we evaluated potential efficacy mechanism action acids...
// Hongzhan Liao 1,* , Yifeng Bai 2,* Shengcong Qiu 1 Lei Zheng 3 Lianyan Huang 4 Tianzhu Liu Xin Wang Yanting Ningbo Xu Xiaohui Yan 5 and Hongbo Guo Department of Neurosurgery, Neurosurgery Institute Guangdong, Key Laboratory on Brain Function Repair Regeneration Zhujiang Hospital, Southern Medical University, Guangzhou, China 2 Oncology, Sichuan Academy Sciences & Provincial People’s Chengdu, Medicine, Nanfang School Public Health Tropical Research Center Clinical * These authors...
Abstract Temozolomide (TMZ) resistance is a major cause of recurrence and poor prognosis in glioblastoma (GBM). Recently, increasing evidences suggested that long noncoding RNAs (LncRNAs) modulate GBM biological processes, especially to chemotherapy, but their role TMZ chemoresistance has not been fully illuminated. Here, we found LncRNA SOX2OT was increased TMZ-resistant cells recurrent patient samples, abnormal expression correlated with high risk relapse prognosis. Knockdown suppressed...
N6-methylation of adenosine (m6A) is one the most frequent chemical modifications in eukaryotic RNAs and plays a vital role tumorigenesis progression. Recently, emerging studies have shown that m6A modification by ALKBH5 was associated with immunotherapy response various types cancer. However, whether demethylases participate regulating tumor immune microenvironment efficacy glioblastoma remain unknown. Here, we found deletion significantly inhibited growth glioma allografts, rescued...
Abstract Temozolomide (TMZ) and radiation therapy combination for glioblastoma (GB) patients has been considered as the most effective after surgical procedure. However, overall clinical prognosis remains unsatisfactory due to intrinsic or developing resistance TMZ. Recently, increasing evidence suggested that long noncoding RNAs (lncRNAs) play a critical role in various biological processes of tumors, have implicated drugs. lncRNAs TMZ is poorly understood. Here, we found expression lncRNA...
The discovery of long noncoding RNAs (lncRNAs) has improved the understanding development and progression in various cancer subtypes. However, role lncRNAs temozolomide (TMZ) resistance glioblastoma multiforme (GBM) remains largely undefined. In this present study, differential expression was identified between U87 TMZ-resistant (TR) cells. lncRNA XLOC013218 (XLOC) drastically upregulated TR cells associated with poor prognosis glioma. Overexpression XLOC markedly increased TMZ resistance,...
// Yanting Liu 1, * , Ningbo Xu Boyang 1 Yiru Huang Huijun Zeng Zhao Yang Zhenyan He Hongbo Guo The National Key Clinical Specialty, Engineering Technology Research Center of Education Ministry China, Guangdong Provincial Laboratory on Brain Function Repair and Regeneration, Department Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China These authors have contributed equally to this work Correspondence to: Guo, email: guohongbo911@126.com Keywords: lncRNA,...
After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a naturally occurring protein that has been shown to have protective effects the brain for traumatic injury. Although wnt3a investigated phenomena neurogenesis, anti-apoptosis, and anti-inflammation, it never as therapy stroke. We hypothesized potential neuroprotective agent would reduce infarction improve behavior following stroke by attenuating neuronal promoting cell survival through...
Abstract Hypoxic–ischemic encephalopathy (HIE) is a devastating neurological event that contributes to the prolonged neurodevelopmental consequences in infants. Therapeutic strategies focused on attenuating neuronal apoptosis penumbra appears be promising. Given increasingly recognized neuroprotective roles of adipokines HIE, we investigated potential anti-apoptotic novel member adipokines, Chemerin, an experimental model HIE. In present study, 10-day-old rat pups underwent right common...
Abstract Adropin is expressed in the CNS and plays a crucial role development of stroke. However, little currently known about effects adropin on blood‐brain barrier ( BBB ) function after intracerebral hemorrhage ICH ). In this study, collagenase‐induced was investigated mice. At 1‐h post‐ , mice were administered with recombinant human by intranasal. Brain water +content, permeability, neurological measured at different time intervals. Proteins quantified using western blot analysis,...
Hematoma clearance has been a proposed therapeutic strategy for hemorrhagic stroke. This study investigated the impact of CX3CR1 (CX3C chemokine receptor 1) activation mediated by r-FKN (recombinant fractalkine) on hematoma resolution, neuroinflammation, and underlying mechanisms involving AMPK (AMP-activated protein kinase)/PPARγ (peroxisome proliferator-activated gamma) pathway after experimental germinal matrix hemorrhage (GMH).A total 313 postnatal day 7 Sprague Dawley rat pups were...
Abstract Limited benefits and clinical utility of temozolomide (TMZ) for glioblastoma (GB) are frequently compromised by the development acquired drug resistance. Overcoming TMZ resistance uncovering underlying mechanisms challenges faced during GB chemotherapy. In this study, we reported that connective tissue growth factor (CTGF) was associated with chemoresistance significantly upregulated in TMZ-treated cells. CTGF knockdown promoted TMZ-induced cell apoptosis enhanced chemosensitivity,...
Background Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about connectivity were identified, synaptosomal-associated 25 (SNAP25), one of those proteins, was found to have discrepant expression levels neuropathies. However, specific mechanism prognostic value SNAP25 during glioma remain...
Adiponectin (APN), a fat-derived plasma hormone, is classic anti-inflammatory agent. Multiple studies have demonstrated the beneficial role of APN in acute brain injury, but effect germinal matrix hemorrhage (GMH) unclear, and underlying molecular mechanisms remain largely undefined. In current study, we used GMH rat model with rh-APN treatment, observed that protective on neurological function an inhibitory neuroinflammation after GMH. To further explore these effects, found expression...
Abstract Background Reactive astrocytes participate in various pathophysiology after subarachnoid hemorrhage (SAH), including neuroinflammation, glymphatic–lymphatic system dysfunction, brain edema, BBB disruption, and cell death. Astrocytes transform into two new reactive phenotypes with changed morphology, altered gene expression, secretion profiles, termed detrimental A1 beneficial A2. This study investigates the effect of 67LR activation by PEDF-34, a PEDF peptide, on neuroinflammation...
Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associated with glioblastoma (GBM) cells vitro. The TMZ-resistant (TR) of GBM sub-cell lines were established through repetitive exposure increasing concentrations differentially...
Abstract Blood brain barrier (BBB) disruption is an important contributor to edema and neurological deficits following intracerebral hemorrhage (ICH). Macrophage stimulating protein (MSP) a hepatocyte growth factor‐like that mediates its functions via activating receptor tyrosine kinase recepteur d'origine nantais (RON). Grb2‐associated binder 1 (GAB1) docking downstream signal transduction pathways. This study aimed evaluate the role of MSP RON activated signaling pathway in preserving BBB...
Germinal matrix hemorrhage (GMH) is a common neurologic event with high morbidity and mortality in preterm infants. Spleen has been reported to play critical role inflammatory responses by regulating peripheral immune cells which contributes secondary brain injury. The current study investigated the mechanistic of biliverdin reductase-A (BLVRA) splenic response damage neonates following collagenase GMH model. Neurological outcomes weights were assessed. Neutrophil production infiltration...
Endoplasmic Reticulum (ER) stress is a major pathology encountered after hypoxic-ischemic (HI) injury. Accumulation of unfolded proteins triggers the protein response (UPR) resulting in activation pro-apoptotic cascades causing cells to die. Here we identified Bax Inhibitor-1 (BI-1), an evolutionary encoded by Transmembrane inhibitor Motif Containing 6 (TMBIM6) gene, as novel modulator ER stress-induced apoptosis HI brain injury neonatal rat pup. The main objective our study overexpress...