Lei Wu

ORCID: 0009-0005-7802-1666
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About
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Research Areas
  • Renal Diseases and Glomerulopathies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Parkinson's Disease Mechanisms and Treatments
  • Nutritional Studies and Diet
  • Biochemical and Molecular Research
  • Nerve injury and regeneration
  • Nutrition, Genetics, and Disease
  • Antibiotics Pharmacokinetics and Efficacy
  • Tissue Engineering and Regenerative Medicine
  • Hepatitis C virus research
  • Electrospun Nanofibers in Biomedical Applications
  • Hepatitis B Virus Studies
  • Pancreatic and Hepatic Oncology Research
  • Pneumonia and Respiratory Infections
  • Vasculitis and related conditions
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Cancer-related molecular mechanisms research
  • Immune cells in cancer
  • Systemic Lupus Erythematosus Research
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Endoplasmic Reticulum Stress and Disease
  • Chronic Lymphocytic Leukemia Research
  • MRI in cancer diagnosis

Sichuan University
2024

Loma Linda University
2023

Guangdong Provincial People's Hospital
2023

Yangzhou University
2018-2021

Peking University First Hospital
2008-2011

Peking University
2008-2011

Ningxia Medical University
2011

King University
2008

Background.The recently published histopathologic classification of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis might greatly aid in the prognostication patients at time diagnosis. This study aims to re-evaluate new for its prognostic capacity an independent Chinese series.

10.1093/ndt/gfr643 article EN Nephrology Dialysis Transplantation 2011-11-25

The renal pathological manifestations of malignancy-associated membranous nephropathy (M-MN) and idiopathic (I-MN) are similar. It has been suggested that glomerular IgG4 deposition may play an important role in the pathogenesis I-MN. In present study, we compared IgG subclass immune complex deposition, clinical data patients with M-MN Eight 42 I-MN diagnosed between 1997 2009 our hospital were enrolled. retrospectively collected, was detected by immunohistochemistry. Patients older (P =...

10.1093/ndt/gfr534 article EN Nephrology Dialysis Transplantation 2011-10-05

Hematoma clearance has been a proposed therapeutic strategy for hemorrhagic stroke. This study investigated the impact of CX3CR1 (CX3C chemokine receptor 1) activation mediated by r-FKN (recombinant fractalkine) on hematoma resolution, neuroinflammation, and underlying mechanisms involving AMPK (AMP-activated protein kinase)/PPARγ (peroxisome proliferator-activated gamma) pathway after experimental germinal matrix hemorrhage (GMH).A total 313 postnatal day 7 Sprague Dawley rat pups were...

10.1161/strokeaha.123.043005 article EN cc-by-nc-nd Stroke 2023-07-19

Objective: To explore the effect of a whole-course nursing objective management system on disease control and quality life in patients with type 2 diabetes, to propose strategies for constructing such these patients. Methods: Ninety diabetes admitted Department Endocrinology hospital from January 2024 June were selected. The group (n = 45) received routine care, while observation nursing. Indicators as glucose metabolism compliance behavior measured before after health both groups evaluated....

10.26689/jcnr.v9i1.9504 article EN Journal of Clinical and Nursing Research 2025-02-13

Objective. Anti-C1q antibodies are common in sera from patients with lupus nephritis (LN) and associated disease activity. The current study aimed to further investigate the prevalence of serum IgG anti-C1q antibody, its subclass distribution their clinical pathological association LN. Methods. Sera were collected 150 renal biopsy-proven LN, diagnosed 2000 2006 our hospital, 30 systemic erythematosus (SLE) without evidence involvement (non-renal SLE, NR-SLE) 63 healthy donors. ELISA was used...

10.1093/ndt/gfn453 article EN Nephrology Dialysis Transplantation 2008-08-06

The present study examined the effect of high-dose cefoperazone-sulbactam combined with tigecycline against ventilator-associated pneumonia (VAP) caused by extensively drug-resistant Acinetobacter baumannii(XDR-AB).42 patients VAP due to XDR-AB infection were randomized into two groups: TIG group (received injection) and TIG+CFS (1 : 1) injection). Pulsed field gel electrophoresis (PFGE) was used for genotyping isolated XDR-AB. microdilution method test minimum inhibitory concentration (MIC)...

10.5414/cp203102 article EN International Journal of Clinical Pharmacology and Therapeutics 2018-01-10

Several prognostic scoring systems have been developed to assess prognosis in myelodysplastic syndrome (MDS). However, currently there are no that list gender as a factor. We queried National Cancer Institute database investigate the influence of on survival patients with MDS. first identified 34,681 qualified diagnosed MDS from 2001-2014 Surveillance, Epidemiology, and End Results (SEER) database, then analyzed characteristics these using chi-squared tests. The Kaplan-Meier method...

10.7150/jca.28220 article EN cc-by-nc Journal of Cancer 2019-01-01

Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence the effect of long-term serum fluctuations on future T2DM probability remains limited.A total 4475 nondiabetic participants who underwent annual health examinations between 2010 and 2013 were followed subsequent 5-year T2DM. The Cox proportional hazards model was performed to evaluate associations visit-to-visit variabilities trajectories triglycerides (TG),...

10.1186/s12944-021-01592-9 article EN cc-by Lipids in Health and Disease 2021-11-27

e16320 Background: While long-standing diabetes mellitus (LsDM) is an etiologic factor for PC, new-onset (NoDM) has been considered as a manifestation and harbinger of this cancer well. Current evidence support that the PC-associated NoDM was mainly caused by disease exocrine pancreas, which different from typical type 2 DM. Therefore, we hypothesize that, in patients, CT image features “normal” pancreas patients might be We sought to develop validate risk prediction model facilitate...

10.1200/jco.2023.41.16_suppl.e16320 article EN Journal of Clinical Oncology 2023-06-01

Objective To study the difference of diet pattern between colorectal cancer patients and healthy volunteer. Methods Food Frequency Questionnaire was applied to obtain data 40 72 volunteers. Then daily intake macronutrients micronutrients were calculated compared two groups. Results The energy significantly higher in than volunteers (Z=-2.836, P=0.005), protein carbohydrates also significant high (Z=-2.065, P=0.018; Z=-2.368, P=0.039). In addition, took more carotene, thiamine,...

10.3877/cma.j.issn.2095-3224.2017.02.004 article EN Chin J Colorec Dis (Electronic Edition) 2017-04-25
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