A5101569916- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Renal Transplantation Outcomes and Treatments
- Medical Research and Treatments
- Cervical Cancer and HPV Research
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Cardiac Fibrosis and Remodeling
- Dysphagia Assessment and Management
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lipoproteins and Cardiovascular Health
- Signaling Pathways in Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Consumer Attitudes and Food Labeling
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Neurological Disease Mechanisms and Treatments
- Mycobacterium research and diagnosis
- Prenatal Screening and Diagnostics
- Metabolomics and Mass Spectrometry Studies
Peking University
2008-2025
Jiangsu University
2014-2025
Second Affiliated Hospital of Zhejiang University
2024-2025
Peking University First Hospital
2008-2025
Sichuan University
2024
Affiliated Hospital of Jiangsu University
2014-2023
BeiGene (China)
2023
Xi'an Chest Hospital
2021
Fudan University Shanghai Cancer Center
2020
Peking University Third Hospital
2019
Currently, the findings about irisin as a novel myokine related to obesity are inconsistent in overweight/obese people. To our knowledge, no systematic analysis has been conducted evaluate relationship between levels and overweight/obesity.To association circulating overweight/obesity.The Cochrane Library, MEDLINE, SCOPUS, ISI Web of Science were searched retrieve all studies associated with overweight/obesity. Standard mean difference values 95% confidence intervals (CI) estimated pooled...
Objective This study aimed to evaluate the clinical value of urinary biomarkers including kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis. Methods A total 109 biopsy-proven nephritis patients were included 50 healthy individuals used as normal controls. Urinary KIM-1, NGAL, MCP-1 levels measured by ELISA their correlations with histological features assessed. Receiver operating...
585 Background: Collecting duct carcinoma (CDC) originates from the principal cells of collecting ducts in renal medulla and accounts for less than 2% all cell carcinomas (RCCs). Due to its low incidence, transcriptomic features molecular subtypes CDC have only been described small-sample studies. This study employs a multi-omics approach investigate CDC, aiming deepen our understanding provide some references future treatment options. Methods: A total 103 tumor samples 15 paired adjacent...
Abstract Although pathological cardiac hypertrophy is a key driver of heart failure, the underlying mechanisms remain incompletely elucidated. This study investigates role and mechanism deubiquitinating enzyme (DUB) ubiquitin‐specific protease 20 (USP20) in hypertrophy. Transcriptomic profiling hypertrophic hearts shows significant alterations expression DUBs, including remarkable downregulation USP20. USP20 predominantly expressed cardiomyocytes. Co‐immunoprecipitation (Co‐IP) followed by...
Objective. Anti-C1q antibodies are common in sera from patients with lupus nephritis (LN) and associated disease activity. The current study aimed to further investigate the prevalence of serum IgG anti-C1q antibody, its subclass distribution their clinical pathological association LN. Methods. Sera were collected 150 renal biopsy-proven LN, diagnosed 2000 2006 our hospital, 30 systemic erythematosus (SLE) without evidence involvement (non-renal SLE, NR-SLE) 63 healthy donors. ELISA was used...
Background. Thrombotic thrombocytopaenic purpura–haemolytic uraemic syndrome (TTP–HUS) in SLE was reported mainly isolated case reports. The aim of this study is to investigate the clinical and pathological features, outcome possible pathogenesis TTP–HUS patients with lupus nephritis. Methods. Clinical renal histopathological data nephritis were reviewed for evidence both thrombotic microangiopathy (TMA). Serum ADAMTS-13 activity autoantibodies further studied. Results. Seven TMA identified...
Background: Controversy exists regarding whether EGFR-targeted therapy combined with GEMOX (gemcitabine and oxaliplatin) provides additional benefits over alone for biliary tract cancer patients.Therefore, this meta-analysis of randomized controlled trials (RCTs) was performed to assess the efficacy safety + regimen, subgroup analysis conducted identify groups that might benefit from targeted therapy.Methods: The PubMed, Cochrane Library, ClinicalTrials.govregistries were searched published...
Aim: The aim of this study was to assess clinicopathological characteristics and outcomes a cohort Chinese patients with late onset lupus nephritis. Methods: Clinical, pathological outcome data for nephritis (onset at age ≥50 years) early ≤40 were retrospectively analyzed compared. Results: Among 271 renal biopsy-proven nephritis, 30 identified as having 241 Lower female predominance observed in the ( p = 0.06). interval between presentation diagnosis significantly longer group than 0.003)....
Abstract Background The role of adipokines in the development atherosclerosis (AS) has received increasing attention recent years. This study aimed to explore effects chemerin on functions human endothelial progenitor cells (EPCs) and investigate its lipid accumulation ApoE-knockout (ApoE−/−) mice. Methods EPCs were cultured treated with together specific p38 mitogen-activated protein kinase (MAPK) inhibitor SB 203580 a time- dose-dependent manner. Changes migration, adhesion, proliferation...
Abstract Acute ischemic stroke (AIS) has a high risk of recurrence, particularly in the early stage. The purpose this study was to assess frequency and factors in-hospital recurrence patients with AIS China. A retrospective analysis performed all new-onset who were hospitalized past three years. Recurrence defined as new event, an interval between primary recurrent events greater than 24 hours; other potential causes neurological deterioration excluded. for analyzed using univariate logistic...
Background: Recently, monocyte to high-density lipoprotein cholesterol ratio (MHR) as a novel inflammatory biomarker has drawn lots of attention. This study was conducted in patients with type 2 diabetes mellitus (T2DM) investigate the correlation between MHR and metabolic-associated fatty liver disease (MAFLD). Methods: Totally, 1,051 T2DM from Affiliated Hospital Jiangsu University were enrolled classified MAFLD ( n = 745) group non-MAFLD 306) according diagnostic criteria. In contrast,...
Non‑small cell lung cancer (NSCLC) poses a threat to human health and paclitaxel chemotherapy has been approved for the treatment of this type cancer. However, resistance severely compromises survival rate prognosis patients with NSCLC. The aim present study was investigate role IL‑1β in sensitivity NSCLC cells elucidate underlying mechanism. expression found be upregulated tissues compared healthy adjacent normal epithelial line, respectively, as detected by reverse...
<title>Abstract</title> Pathological cardiac hypertrophy can lead to heart failure. The molecular mechanisms underlying pathological remain undefined. This study aimed examine the role and of a deubiquitinating enzyme (DUB), ubiquitin-specific protease 20 (USP20) in hypertrophy. Hypertrophic hearts were conducted for RNA-sequencing screen expression profiles DUBs. Cardiomyocyte-specific USP20 knockout overexpression mouse models generated explore its function. Co-immunoprecipitation coupled...
Liuzhou cliff inscriptions stand as a significant cultural heritage of the Chinese nation, encapsulating wealth historical, cultural, and artistic value. The emergence creative industries has transformed these into marketable products, which have been seamlessly integrated educational practices, offering novel approach to preservation transmission this heritage. This research systematically examines strategies for developing products based on inscriptions, well their integration contexts,...