A5091642808- Bladder and Urothelial Cancer Treatments
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Genital Health and Disease
- RNA modifications and cancer
- Urinary and Genital Oncology Studies
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Sexual Assault and Victimization Studies
- Pancreatitis Pathology and Treatment
- Circular RNAs in diseases
- Parathyroid Disorders and Treatments
- Soft tissue tumors and treatment
- Lipid metabolism and biosynthesis
Henan Cancer Hospital
2013-2025
Zhengzhou University
2014-2025
Sichuan University
2023
West China Hospital of Sichuan University
2023
Capital Medical University
2019
University of Pittsburgh
2017-2018
Beihua University
2017
Affiliated Zhongshan Hospital of Dalian University
2017
Dalian University of Technology
2015
585 Background: Collecting duct carcinoma (CDC) originates from the principal cells of collecting ducts in renal medulla and accounts for less than 2% all cell carcinomas (RCCs). Due to its low incidence, transcriptomic features molecular subtypes CDC have only been described small-sample studies. This study employs a multi-omics approach investigate CDC, aiming deepen our understanding provide some references future treatment options. Methods: A total 103 tumor samples 15 paired adjacent...
Metastatic renal cell carcinoma (MRCC) is one of the malignancies that are sensitive to immunotherapy. However, underlying immune inhibitory factors such as myeloid-derived suppressor cells (MDSCs) might restrain efficacy The present study investigates clinical cytokine-induced killer (CIK) therapy in patients with MRCC and explores whether levels peripheral MDSCs associated prognosis receiving this therapy. Twenty-nine measurable were treated an adoptive transfer autologous CIK cells,...
Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both preclinical and preliminary clinical data indicate that cytokine-induced killer (CIK) cells are an effective tool against various types of solid tumors. Here, we conducted a study determine whether CIK cell-based therapy (CBT) can improve the outcomes advanced PC. Eighty-two patients PC, whose predicted survival time was longer...
Renal cell carcinoma (RCC) is a common malignant tumour of the genitourinary system. We aimed to analyse potential value metastasis-related biomarkers, circulating cells (CTCs) and proliferative marker Ki-67 in diagnosis RCC.Data from 24 laparoscopic radical nephrectomies (RNs) 17 partial (PNs) were collected 2018. The numbers positive rates CTCs microemboli (CTM) peripheral blood obtained at three different time points: just before surgery, immediately after surgery 1 week surgery. protein...
Osteoarthritis (OA) is a complex arthritic condition in which the genetic factor plays major role. One of candidate genes ADAM12 gene, but no consistency has been reached till now. This study aims to investigate potential role four single nucleotide polymorphisms (SNPs) gene susceptibility knee OA and its progression Chinese Han population.The rs1278279, rs3740199, rs1044122, rs1871054 were genotyped compared population based cohort consisting 164 subjects 200 age- gender-matched...
Background Rheumatoid arthritis (RA) is a chronic auto-inflammatory disorder of joints. The present study aimed to identify the key genes in RA for better understanding underlying mechanisms RA. Methods integrated analysis expression profiling was conducted differentially expressed (DEGs) Moreover, functional annotation, protein–protein interaction (PPI) network and transcription factor (TF) regulatory construction were applied exploring potential biological roles DEGs In addition, level...
Background: Bladder cancer (BLCA) is a common malignant tumor of the genitourinary system, and there lack specific, reliable, non-invasive biomarker tests for diagnosis prognosis evaluation. Homeobox genes play vital role in BLCA tumorigenesis development, but few studies have focused on prognostic value homeobox BLCA. In this study, we aim to develop signature associated with gene family Methods: The RNA sequencing data, clinical probe annotation files patients were downloaded from Gene...
Elongation factor, RNA polymerase II, 2 (ELL2) is an Pol II elongation factor with functional properties similar to ELL that can interact the prostate tumor suppressor EAF2. In prostate, ELL2 androgen response gene upregulated in benign prostatic hyperplasia (BPH). We recently showed loss could enhance cancer cell proliferation and migration, expression was downregulated high Gleason score specimens. Here, prostate-specific deletion of a mouse model revealed potential role for as...
Human epidermal growth factor receptor 2 (HER2) has become a well-established target for the treatment of HER2-positive lung cancer. However, frequently observed in-frame mutation that inserts amino acid quadruplex Tyr776-Val777-Met778-Ala779 at G776 (G776YVMA) in HER2 kinase domain can cause drug resistance and sensitivity, largely limiting application reversible tyrosine inhibitors cancer therapy. A systematic investigation intermolecular interactions between HER2YVMA mutant clinical...
The prognosis of patients with advanced urothelial carcinoma is dismal. Platinum-based chemotherapy still the main first-line treatment for carcinoma, while immunotherapy can be used as a option people who cannot tolerate platinum. Immunotherapy preferred in second-line bladder carcinoma. PD-1 inhibitors (Pembrolizumab, nivolumab and atezolizumab) PD-L1 (Ddurvalumab avelumab) have not been approved cancer China. We describe patient experienced disease progression after gemcitabine...
Background : Bladder cancer (BLCA) ranks 10th in incidence among malignant tumors and 6th males. With the application of immune therapy, overall survival (OS) rate BLCA patients has greatly improved, but 5-year is still low. Furthermore, not every patient benefits from immunotherapy, there are a limited number biomarkers for predicting immunotherapy response. Therefore, novel response prognosis urgently needed. Methods The RNA sequencing (RNA-seq) data, clinical data gene annotation files...
Background Elongation factor for RNA polymerase 2 (ELL2) and ELL associated (EAF2) have been reported to tumor suppressive properties in prostate epithelial cells. Aims We investigated ELL2 expression human cancer specimens, protein stability ubiquitination Materials Methods Immunostaining analysis of specimens was used determine normal tissues. knockdown cell lines LNCaP C4‐2 compare proliferation motility. Deletion site‐directed mutagenesis identify amino acid residues that were important...
Abstract Background Inguinal lymphadenectomy (iLAD) is effective for penile carcinoma treatment, but usually results in many complications. This study aims to clinically evaluate the feasibility and clinical significance of a laparoscopic radical iLAD approach partly preserving great saphenous vein branches patients. Methods A total 48 patients with cancer who underwent retention Henan Cancer Hospital from 2012 Jan 2020 Dec were included this study. Sixteen parts superficial identified as...
Background: Regarding the outbreak of highly contagious 2019 Novel Coronavirus (2019-nCoV) in various countries and regions, data have been needed on early chest CT images clinical characteristics affected patients. Objectives: To explore computed tomography (CT) Disease (COVID-19) patients to improve diagnostic level this respiratory disease. Methods: An analysis retrospectively was implemented radiological features 12 with COVID-19 who had undergone scanning designated hospital from Jan...
Aim: To investigate the correlation between related variables of prostate-specific antigen (PSA) and risk factors in patients with prostate carcinoma. Methods: The clinical records 187 cases carcinoma, diagnosed by biopsy, were retrospectively analyzed to assess PSA density (PSAD), free (FPSA), FPSA/total (TPSA) Results: results from Spearman rank analysis sum test revealed that TPSA FPSA positively correlated for cancer patients, whereas there was no F/TPSA factors. Conclusion: PSAD, FPSA,...
Objective To compare the kidney injury in diabetic patients undergoing liver cancer resection performed under different methods of anesthesia.Methods Sixty both sexes,aged 40-64 yr,weighing 48-75 kg,of ASA physical shatus Ⅱ or Ⅲ (liver function Child-Pugh grade A),scheduled for elective resection,were randomly divided into 2 groups (n =30 each) using a random number table:total intravenous anesthesia with propofol group (group P) and combined intravenous-inhalational sevoflurane S).In S,8％...
Objective To observe the level of eleven-nineteen lysine-rich leukemia gene 2 (ELL2) in human prostate cancer tissues and its effect on proliferation cell C4-2. Methods The expression ELL2 was analyzed by immunohistochemical method, relationship between malignancy degree evaluated. The line C4-2 stimulated with synthetic androgen R1881 to detect response at different time points. ELL2-small interfering RNA (siRNA) overexpression ELL2-bearing plasmid were transfected into cells...
Objective To explore the difference of serum protein in prostate cancer patients and build its diagnosis model. Methods Matrix-assisted laser-desorptionionization time-of-flight mass spectrometry (MALDI-TOF-MS) combined with WCX beads technique was used to analyze differences peptides between 48 castration sensitivity/resistant (CSPC/CRPC) 21 healthy volunteers. Results Polypeptides fingerprint built within 28 peptides, screened by chemometircs. Meanwhile, supervised model least...
Objective To review the experience of clinical diagnosis and treatment primary testicular diffuse large B-cell lymphoma. Methods A was made who were treated in Tumor Hospital Zhengzhou University from January 2011 to November 2018. The average age patients 58 years old, with 4 cases left side 8 right side. All admitted hospital painless testicle mass. Solid mass testis detected by ultrasound no abnormality tumor markers. underwent orchiectomy followed...