Abstract Background In the present study, we aim to investigate potential role of propofol in tumor progression colon cancer. Methods Human cancer cell lines were cultured and exposed with 8 μg/mL propofol. RNA interference was performed silence expression HOTAIR or STAT3 explore their biological functions Cell apoptosis invasion assessed using flow cytometry transwell assays, respectively. Quantitative real‐time PCR, western blot, immunohistochemistry subjected measure patterns HOTAIR,...

A new kind of phase change material n-octadecane microcapsules containing peppermint fragrance scent has been synthesized through the interfacial polymerization isophorone diisocyanate (IPDI) and hexamethylenediamine (HMDA). The average size, morphology, chemical components were characterized by laser particle size analyzer, scanning electron microscope (SEM), Fourier transform infrared (FTIR), respectively. thermal characterizations studied differential calorimetry (DSC) gravity analysis...

BACKGROUND Postoperative pain management and cognitive function preservation are crucial for patients undergoing thoracoscopic surgery lung cancer (LC). This is achieved using either a thoracic paravertebral block (TPVB) or sufentanil (SUF)-based multimodal analgesia. However, the efficacy impact of their combined use on postoperative dysfunction (POCD) remain unclear. AIM To explore analgesic effect influence POCD TPVB with SUF-based analgesia in radical resection LC to help optimize...

Many studies have demonstrated the crucial roles of 5-methylcytosine (m5C) RNA methylation in cancer pathogenesis.Two datasets, including TCGA-KIRP and ICGC, related clinical information were downloaded, where expression 13 m5C regulators was examined. We applied LASSO regression to construct a multi-m5C-regulator-based signature TCGA cohort, which further validated using ICGC cohort. Univariate multivariate Cox regressions evaluate independent prognostic value our model. The differences...

Objective: To investigate the effects of remimazolam versus propofol on postoperative recovery quality in elderly patients undergoing thoracoscopic laparoscopic radical esophagectomy. Methods: A total 108 esophagectomy under general anesthesia Affiliated Cancer Hospital Zhengzhou University from May to October 2022 were prospectively included. The participants divided into two groups by random number table method: group (R group, n=54) and (P n=54). There 54 cases R with 35males 19 females,...

Background Propofol has been reported to be related the migration, invasion, and epithelial‐mesenchymal transition (EMT) of esophageal cancer (EC) cells. However, detailed mechanism not yet fully reported. The purpose this research was elucidate function long non‐coding RNA TMPO antisense 1 (lncRNA TMPO‐AS1) microRNA‐498 (miR‐498) in propofol‐regulated EC. Methods Transwell assay performed assess cell migratory invasive abilities. Western blot employed determine levels EMT markers hypoxia...

The objective was to evaluate the effect of patient-controlled intravenous analgesia (PCIA) in non-small cell lung cancer patients (NSLCPs) after thoracotomy.From January 2014 March 2015, 40 were recruited this study and divided into two groups, group control with 20 each group. PCIA connected self-control pump which contains 2 μg/ml sufentanil 8 mg ondansetron diluting 100 ml 0.9% saline surgery. Initial loading dose ml, background ml/h, single 0.5 locking time 15 min. 10 morphine...

Background Perioperative anemia and transfusion are intertwined with each other, both have adverse impacts on the survival of colorectal cancer (CRC) patients. But treatment still relies in several countries, which leads us to question effects tolerance long-term outcomes CRC We investigated combined effect preoperative postoperative blood transfusion, imposes a greater risk survival, compare overall (OS) disease-free (DFS) patients undergoing surgery. Methods A retrospective...

Purpose: To analyze the short- and long-term effect of perioperative blood transfusion (PBT) in patients undergoing surgical treatment for oral squamous cell carcinoma (SCC). Methods: Patients free flap reconstruction were retrospectively enrolled divided into two groups based on implementation PBT. Flap revision, site infection (SSI), failure, overall survival (OS), disease-specific (DSS) compared between groups. Results: In 170 with PBT, 10 (5.9%) flaps required exploration SSI occurred 18...

Background Tumors may induce systemic immune dysfunction, which can be aggravated by surgery and anesthesia/analgesia. Data on the effect of flurbiprofen preemptive analgesia dysfunction is limited. The aim this study was to investigate lymphocytes natural killer ( NK ) cells in patients undergoing thoracotomy thoracoscopy radical esophagectomy, explore analgesic methods suitable for tumor patients. Methods This a randomized controlled pilot 89 with esophageal cancer treated at H enan C...

Objective: To analyze the effects of desflurane and sevoflurane anesthesia on postoperative recovery after long lasting tumor surgery. Methods: One hundred sixty patients undergoing endoscopic radical esophagectomy gastrectomy (80 cases each surgical type) from November 2019 to March 2020 at Henan Cancer Hospital, were randomized into 4 groups(n=40): group CS (esophageal cancer+sevoflurane anesthesia), DS cancer+desflurane anesthesia),group CW (stomach anesthesia) DW (gastric anesthesia)....

The aim of this study was to observe the efficacy and safety single-lumen tracheal ventilation for esophageal cancer surgery.Thirty-eight patients with carcinoma who prepared minimally invasive esophagectomy were included in study. All 38 received ventilation. arterial blood gas index monitored through operation procedure recorded at four-time points: before induction (T0), end chest (T1), abdominal (T2), 30 min after extubation (T3). heart rate (HR) pressure (BP) also during period PetCO2...

Objective: To observe the efficacy and safety of S(+)-ketamine combined with sufentanil for patient-controlled intravenous analgesia (PCIA) in elderly patients undergoing laparoscopic radical resection rectal cancer explore its impact on patients' early recovery. Methods: One hundred ten Affiliated Cancer Hospital Zhengzhou University from December 2020 to March 2021, were divided into two groups (n=55) using a random number table: group S received PCIA, continuous infusion sufentanil, while...

Minimally invasive esophagectomy (MIE) has been identified as an oncological method with lower mortality and morbidity. This procedure is usually performed under general anesthesia using double endotracheal tube intubation one-lung ventilation for a good visualization like other video-assisted thoracoscopic surgery (VATS). However, it difficult to differentiate weather the postoperative hoarseness caused by or recurrent laryngeal nerve injury during operation, some complications related also...

ABSTRACT Background Esketamine (ESK), a noncompetitive antagonist of N‐methyl‐D‐aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous system. However, specific mechanisms and therapeutic potential ESK for intracerebral hemorrhage (ICH) remain unclear. This study aimed to investigate whether promotes nerve repair improves neurological outcomes an experimental model ICH. Methods ICH was induced mice via collagenase injection into striatum. Body weight,...

Abstract BACKGROUND Ischemia/reperfusion (I/R) injury may significantly affect the treatment outcomes and prognosis of patients with acute myocardial infarction following coronary artery recanalization. Available evidence suggests that neuregulin-1 (NRG-1) can provide a protection against I/R is involved in various cardioprotective interventions by potential regulation mitophagy. However, molecular mechanisms linking NRG-1 mitophagy remain to be clarified. This experiment aimed determine...

Objective: To investigate the effects of patient-controlled intravenous analgesia with butorphanol versus sufentanil on early postoperative rehabilitation following radical laparoscopic nephrectomy. Methods: One hundred patients undergoing nephrectomy in Affiliated Cancer Hospital Zhengzhou University from September 2018 to February 2020 were divided into two groups (n=50) using a random number table: group (group A) and B). Patient-controlled (PCIA) was performed at end surgery. The...

Objective To compare the kidney injury in diabetic patients undergoing liver cancer resection performed under different methods of anesthesia.Methods Sixty both sexes,aged 40-64 yr,weighing 48-75 kg,of ASA physical shatus Ⅱ or Ⅲ (liver function Child-Pugh grade A),scheduled for elective resection,were randomly divided into 2 groups (n =30 each) using a random number table:total intravenous anesthesia with propofol group (group P) and combined intravenous-inhalational sevoflurane S).In S,8％...

Objective To evaluate the role of nuclear factor erythroid 2-related 2 (Nrf2)/antioxidant response element (ARE) signaling pathway in propofol-induced reduction lung ischemia-reperfusion (I/R) injury aged rats. Methods Thirty-two clean healthy male Sprague-Dawley rats, 18-22 months, weighing 450-600, were divided into 4 groups (n=8 each) using a random number table: sham operation group (group S), I/R I/R), plus propofol I/R+ P) and all-trans retinoic acid (ARTA) ARTA+ P). Lung was...

Objective To evaluate the role of glycogen synthase kinase-3 beta (GSK-3β) in spinal cord ischemia/reperfusion (I/R) injury rats.Methods Forty-eight male Sprague-Dawley rats,aged 3 months,weighing 250-300 g,were randomly divided into groups (n =16 each) using a random number table:sham operation group (group S),group I/R and I/R+ GSK-3β inhibitor LiCl LiCl).The animals were anesthetized with intraperitoneal 10％ chloral hydrate 300 mg/kg.Spinal ischemia was induced by 45 min occlusion...

Objective To evaluate the effect of penehyclidine hydrochloride on damage to non-ventilated lung in pediatric patients undergoing one-lung ventilation(OLV). Methods One hundred and twenty both sexes, aged 2-6 yr, with body mass index 17-24 kg/m2, American Society Anesthesiologists physical statusⅠ or Ⅱ New York Heart Association classⅠ Ⅱ, elective lobectomy performed via video-assisted thoracoscope, were randomly divided into 2 groups(n=60 each)using a random number table: control...

Objective To evaluate the effects of sulforaphane preconditioning on cognitive dysfunction induced by sevoflurane anesthesia in aged rats.Methods Thirty Sprague-Dawley rats,aged 22 months,weighing 380-560 g,were randomly divided into 3 groups (n =10 each) using a random number table:control group,sevoflurane group (Sev group),and (Sul group).In Sul,sulforaphane25 mg/kg was administered oral gavage once day for 7 consecutive days,while equal volume distilled water given instead Sev and C...