Li Shen

ORCID: 0000-0002-0069-1310
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About
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Research Areas
  • Radiation Dose and Imaging
  • Colorectal Cancer Surgical Treatments
  • Colorectal and Anal Carcinomas
  • Advanced X-ray and CT Imaging
  • Genital Health and Disease
  • Pectus Deformity Diagnosis and Treatment
  • Respiratory viral infections research
  • RNA modifications and cancer
  • Medical Imaging Techniques and Applications
  • Anesthesia and Pain Management
  • Gastric Cancer Management and Outcomes
  • Pneumonia and Respiratory Infections
  • Uterine Myomas and Treatments
  • Head and Neck Anomalies
  • Cancer survivorship and care
  • Pancreatic and Hepatic Oncology Research
  • Maternal and fetal healthcare
  • Microbial Natural Products and Biosynthesis
  • Endometrial and Cervical Cancer Treatments
  • Childhood Cancer Survivors' Quality of Life
  • Ultrasound in Clinical Applications
  • Thermal Regulation in Medicine
  • Thyroid and Parathyroid Surgery
  • Cytokine Signaling Pathways and Interactions
  • Venous Thromboembolism Diagnosis and Management

Nanjing University
2025

Suzhou Municipal Hospital
2025

Huazhong University of Science and Technology
2024

Shanghai Clinical Research Center
2023

Shanghai Jiao Tong University
2023

Zero to Three
2023

Shanghai Sixth People's Hospital
2023

Fudan University Shanghai Cancer Center
2023

Yixing People's Hospital
2023

Jiangsu University
2023

Osteoporotic vertebral fracture (OVF) is a risk factor for morbidity and mortality in elderly population, accurate diagnosis important improving treatment outcomes. OVF suffers from high misdiagnosis underdiagnosis rates, as well workload. Deep learning methods applied to plain radiographs, simple, fast, inexpensive examination, might solve this problem. We developed validated deep-learning-based diagnostic system using area loss ratio, which assisted multitasking network perform skeletal...

10.1002/jbmr.4879 article EN cc-by-nc-nd Journal of Bone and Mineral Research 2023-07-14

Background Community-acquired pneumonia (CAP) is a prevalent pediatric condition, and lobar (LP) considered severe subtype. Early identification of LP crucial for appropriate management. This study aimed to develop compare machine learning models predict in children with CAP. Methods A total 25 clinical laboratory variables were collected. Missing data (<2%) imputed, the dataset was split into training (60%) validation (40%) sets. Univariable logistic regression Boruta feature...

10.3389/fped.2025.1490500 article EN cc-by Frontiers in Pediatrics 2025-03-07

Objective: Total neoadjuvant therapy has been used to improve tumor responses and prevent distant metastases in patients with locally advanced rectal cancer (LARC). Patients complete clinical (cCR) then have the option of choosing a watch wait (W&W) strategy organ preservation. It recently shown that hypofractionated radiotherapy better synergistic effects PD-1/PD-L1 inhibitors than does conventionally fractionated radiotherapy, increasing sensitivity microsatellite stable (MSS) colorectal...

10.3760/cma.j.cn441530-20230107-00010 article EN PubMed 2023-05-25

Many studies have demonstrated the crucial roles of 5-methylcytosine (m5C) RNA methylation in cancer pathogenesis.Two datasets, including TCGA-KIRP and ICGC, related clinical information were downloaded, where expression 13 m5C regulators was examined. We applied LASSO regression to construct a multi-m5C-regulator-based signature TCGA cohort, which further validated using ICGC cohort. Univariate multivariate Cox regressions evaluate independent prognostic value our model. The differences...

10.1016/j.tranon.2023.101741 article EN cc-by-nc-nd Translational Oncology 2023-07-29

Application of dual-energy CT in characterization adrenal nodules has not been well evaluated.To evaluate the ability scan to differentiate an adenoma from a metastasis.Fifty-five patients presenting 63 underwent at tube voltages 80 kVp and 140 kVp. Mean attenuation values were measured for every nodule 80/140 40/100 keV. value changes between (MAVC140-80kVp) mean 100 keV 40 (MAVC100-40keV) calculated.Of available analyses, 42 classified as (26 lipid-rich 16 lipid-poor) 21 metastases....

10.1177/0284185113501660 article EN Acta Radiologica 2013-08-23

Objective: To assess radiation dose and image quality of chest CT examinations in low-weight children acquired at ultralow tube voltage (70 kVp) combined with Flash scan technique. Materials methods: 30 consecutive paediatric patients (weight <20 kg) required non-contrast 70 kVp mode (Group A). for standard 80-kVp protocols conventional spiral B) were selected from the picture archiving communication system. For each examination, volume index (CTDIvol) dose–length product (DLP), effective...

10.1259/bjr.20150184 article EN British Journal of Radiology 2016-01-19

To explore the molecular targets and mechanism of YuPingFeng (YPF) for treatment asthma by using network pharmacology docking. The potential active ingredients relevant YPF were obtained from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP). Asthma-related gene retrieved GeneCards, OMIM, DrugBank, PharmGKB, TTD databases. protein-protein (PPI) between common was constructed SRING online database Cytoscape software. GO KEGG analyses performed to complicated...

10.1155/2022/7364126 article EN cc-by Computational and Mathematical Methods in Medicine 2022-09-05

Hepatocellular carcinoma (HCC) is characterized by high mortality, difficulty in early screening, relapse, and poor prognosis. This study aimed to explore the expression of ethanolamine-phosphate phospho-lyase (ETNPPL) its clinical significance HCC.Differentially expressed mRNAs were screened using microarray analysis. Functional enrichment was performed GO (Gene Ontology) KEGG (Kyoto Encyclopedia Genes Genomes) We used qRT-PCR measure ETNPPL HCC tissues paired paracarcinoma tissues. A...

10.7717/peerj.15834 article EN cc-by PeerJ 2023-08-21

As the gold standard for imaging sinus disease, main disadvantage of computed tomography (CT) pediatric paranasal is radiation exposure. Because this, 1 protocol CT should reduce dose while maintaining image quality. The aim this study to evaluate quality dose-reduced using an ultralow tube voltage (70 kVp) combined with iterative reconstruction (IR) in children.CT scans were performed different protocols [70 kVp IR, Group A, n = 80; 80 a filtered back projection algorithm, B, 80] 160...

10.1097/md.0000000000021886 article EN cc-by-nc Medicine 2020-08-19

Objective. Exploration of the underlying molecular mechanism Jinchan Oral Liquid (JOL) in treating children with respiratory syncytial virus (RSV) pneumonia to provide new evidence for clinical application. Methods. The active components and target genes JOL were screened by TCMSP database. targets RSV obtained from GeneCards, OMIM, DrugBank, PharmGKB Then, we constructed component-target network core genes. overlaps PPI analysis, GO KEGG analysis. Finally, result validation was performed...

10.1155/2021/6471400 article EN cc-by BioMed Research International 2021-08-26

To obtain the normal values of fractional concentration nasal nitric oxide in Chinese children aged 6-18 years, so as to provide reference for clinical diagnosis.2,580 out 3,200 (1,359 males and 1,221 females), whom were included from 12 centers around China taken tests, their height weight also recorded. Data used analyze range influencing factors values.Data was measured using Nano Coulomb Breath Analyzer (Sunvou-CA2122, Wuxi, China), according American Thoracic Society/European...

10.3389/fped.2023.990510 article EN cc-by Frontiers in Pediatrics 2023-05-09

Existing evidence suggests that palliative care (PC) is highly underutilized in metastatic gynecologic cancer (mGCa). This study aims to explore temporal trends and predictors for inpatient PC referral mGCa patients who received specific critical therapies (CCT).The National Inpatient Sample from 2003 2015 was used identify receiving CCT. Basic characteristics were compared between with without PC. Annual percentage change (APC) estimated reflect the trend entire cohort subgroups....

10.3389/fonc.2023.1173438 article EN cc-by Frontiers in Oncology 2023-10-19

Objective To review the clinical outcome of Nuss procedure for peetus excavatum in children.Methods From September 2006 to April 2009,one hundred and eighteen children (29 females 89 males) aged 3-16 years (mean 6.4 3.52 years) suffering from pectus underwent procedure.One twelve eases were corrected without assistance thoracoseopie surgery.Three patients had additional lung cyst open surgery other 6 recurrence cases video-assisted thoraeoscopic surgery.Results All successful,with operative...

10.3760/cma.j.issn.0253-3006.2009.10.010 article EN Zhonghua xiaoerwaike zazhi 2009-10-15

Objective To review the clinical experiences of modified Nuss procedure and technique for complicated pectus excavatum. Methods From September 2006 to October 2009,45 children (27 boys and18 girls), aged 3 - 16 years [mean (6.4 ± 3.5 )years] with excavatum underwent procedure. VATS was used in 6 cases. patients associated lung cyst were treated by open surgery 1 case ASD Hybrid procedure.Results The successfully performed all patients. mean operative time 54 minutes average hospital stay 7...

10.3760/cma.j.issn.1001-4497.2010.06.011 article EN Chinese Journal of Thoracic and Cardiovaescular Surgery 2010-12-18

To explore the compression stability in left common iliac vein (LCIV) at different times by contrast-enhanced CT same patients. Methods: This retrospective study included 124 patients (without signs of lower extremity venous diseases), who underwent pelvic cavity and reexamined within one year. The degree changes LCIV was calculated compared between two examinations. Moreover, relationship age rate analyzed. Results: In examinations for patient, almost same, there no significant difference...

10.11817/j.issn.1672-7347.2018.04.019 article EN PubMed 2018-04-28
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