A5100759720- Reproductive Biology and Fertility
- Corneal surgery and disorders
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Medical Research and Treatments
- Ophthalmology and Visual Impairment Studies
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Bone Tissue Engineering Materials
- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Intraocular Surgery and Lenses
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Thyroid Disorders and Treatments
- Kruppel-like factors research
- Cleft Lip and Palate Research
- Microtubule and mitosis dynamics
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Glaucoma and retinal disorders
- Animal Genetics and Reproduction
- Obstructive Sleep Apnea Research
- Berberine and alkaloids research
- COVID-19 and healthcare impacts
Suzhou Municipal Hospital
2025
Nanjing University
2025
Nanjing Maternity and Child Health Care Hospital
2020-2023
Nanjing Medical University
2009-2023
Changzhou No.2 People's Hospital
2015-2023
Chinese PLA General Hospital
2023
Chinese Academy of Agricultural Sciences
2022
Qinghai University Affiliated Hospital
2022
Gansu Provincial Maternal and Child Health Hospital
2022
Hebei Eye Hospital
2021
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC thirteen female (FBC) patients. We find has significantly lower infiltration T relative to FBC. Metastasis-related programs are more active in MBC. The activated fatty acid metabolism involved FASN related cell metastasis low immune show activation p38 MAPK lipid...
Triple negative breast cancer (TNBC) is highly malignant and has a worse prognosis, compared with other subtypes of due to the absence therapeutic targets. KIF23 plays crucial role in tumorigenesis progression. However, development TNBC underlying mechanism remain unknown. The study aimed elucidate biological function regulatory TNBC.Quantitative real-time PCR Western blot were used determine expression tissues cell lines. Then, functional experiments vitro vivo performed investigate effects...
Abstract Purpose To elucidate the characterization of extracellular vesicles (EVs) in follicular fluid-derived (FF-EVs) and discover critical molecules signaling pathways associating with etiology pathobiology PCOS, differentially expressed miRNAs (DEmiRNAs) proteins profiles (DEPs) were initially explored combinedly analyzed. Methods First, miRNA protein expression FF-EVs PCOS patients control compared by RNA-sequencing tandem mass tagging (TMT) proteomic methods. Subsequently, Gene...
Abstract The human zona pellucida (ZP) is a highly organized glycoprotein matrix that encircles oocytes and plays an essential role in successful reproduction. Previous studies have reported mutations ZP1, ZP2 ZP3 influence their functions result lack of ZP or abnormal empty follicle syndrome, which leads to female infertility. Here, we performed whole‐exome sequencing two probands with primary infertility whose lacked ZP, identified heterozygous mutation ZP1 (NM_207341:c.326G>A...
Background Community-acquired pneumonia (CAP) is a prevalent pediatric condition, and lobar (LP) considered severe subtype. Early identification of LP crucial for appropriate management. This study aimed to develop compare machine learning models predict in children with CAP. Methods A total 25 clinical laboratory variables were collected. Missing data (<2%) imputed, the dataset was split into training (60%) validation (40%) sets. Univariable logistic regression Boruta feature...
Ultra performance LC with quadrupole TOF MS (UPLC/Q-TOF-MS) fingerprinting is first developed for the identification of major components Phellodendri Amurensis Cortex (PAC). The PAC samples are separated using a Waters ACQUITY UPLC BEH C18 (2.1×50 mm, 1.7 μm) by linear gradient elution water (containing 0.2% formic acid) and acetonitrile as mobile phase. Ten batches selected to construct UPLC/Q-TOF-MS fingerprint. Sixteen common peaks in fingerprint obtained, ten which tentatively...
PAT1 homolog 2 (PATL2), encoding an RNA-binding protein, is a repressor involved in the translational regulation of maternal mRNAs during oocyte maturation. Previous studies have reported mutations PATL2 those led to female infertility with maturation arrest; however, mechanisms by which affected meiotic remained unclear. Here, we identified several novel and recurrent patients similar phenotype, chose missense mutation c.649 T>A p.Tyr217Asn (PATL2 Y217N ) as typical investigate...
The receptor tyrosine kinase like orphan 2 (ROR2) has been implicated in the pathogenesis of a variety human cancers, including breast cancer. Here, we analyzed clinical significance ROR2 cancer (BC) progression, and its function regulation BC cell proliferation growth. Analysis mRNA levels 45 tissues adjacent non-tumor revealed that expression was significantly increased tissues, it correlated with tumor diameter. Kaplan-Meier disease-free survival (DFS) analysis demonstrated patients...
In recent years, annual incidences of adenoid hypertrophy (AH), a highly common tissue lesion in children, have increased. Currently, research on AH has focused its obstruction nasal cavity function, and little been written influence the upper airway's bone structure. For this reason, our present study seeks to determine both morphological development characteristics airway craniofacial features with goal being offer more choices for diagnosing treating condition future.From June 2019...
The paper studies a periodic and delayed predator-prey system with non-monotonic functional responses stage structure. In the system, both predator prey are divided into immature individuals mature by two fixed ages. It is assumed that predators cannot attack preys, case of attacking preys also ignored. Based on Mawhin's coincidence degree, sufficient conditions obtained for existence positive solutions system. An example presented to illustrate feasibility main results.
Objectives The presence of dural sinus septum has long been identified anatomically but is often neglected for its clinical significance. Our findings revealed the association with venous stenting failure and complications supported by evidence. Methods This retrospective study included 185 consecutive patients treated cerebral from January 2009 to May 2022. We septa using digital subtraction angiography (DSA) classified them into three types based on their location. at transverse were...
PNMA (paraneoplastic antigen MA) family includes Pnma1-6. Although other members have been found to be involved in paraneoplastic neurological disorders, death receptor-dependent apoptosis, and tumorigenesis, Pnma5 was thought a female fertility factor, as indicated by one genome-wide study. But until now there not any further functional studies about meiosis. Our preliminary study that might play important roles To address this, knocked down in-vitro maturated (IVM) mouse oocytes, which are...
The use of mouse oocytes as a model for studying female meiosis is very important in reproductive medicine. Gene knockdown by specific small interfering RNA (siRNA) usually the first step study function target gene during vitro maturation. Traditionally, only way to introduce siRNA into through microinjection, which certainly less efficient and strenuous than transfection somatic cells. Recently, research using cells, peptide nanoparticle-mediated has been gaining popularity over liposome...
Objective. Exploration of the underlying molecular mechanism Jinchan Oral Liquid (JOL) in treating children with respiratory syncytial virus (RSV) pneumonia to provide new evidence for clinical application. Methods. The active components and target genes JOL were screened by TCMSP database. targets RSV obtained from GeneCards, OMIM, DrugBank, PharmGKB Then, we constructed component-target network core genes. overlaps PPI analysis, GO KEGG analysis. Finally, result validation was performed...
Abstract Background Labor represents a period of significant physical activity. Inefficient energy supply may delay labor process and even lead to cesarean delivery. Herein we investigated whether ingestion carbohydrate-rich beverage could reduce delivery in laboring women with epidural analgesia. Methods This multicenter randomized trial was conducted obstetrician-led maternity units nine tertiary hospitals China. Primigravidae single term cephalic pregnancy who were preparing for vaginal...
Abstract Background Immature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool reproductive medicine oocytes. Unfortunately, the efficiency of IVM is not satisfactory. To circumvent this problem, we therefore intended commence with composition ovarian follicular fluid (FF), an important microenvironment influencing oocyte growth. It well known that FF has critical role development and maturation. However, components human remain...
Objectives Women with ovarian cancer (OC) have experienced unprecedented challenges since the novel coronavirus disease-2019 (COVID-19) outbreak in China. We aim to evaluate experience of psychological status, physical symptoms and quality life (QoL) investigate impact COVID-19 pandemic on OC patients receiving olaparib. Methods The survey was conducted online from April 22 May 12 2020. Demographic clinical questions were listed collect general information. degree insomnia, depression,...
The present study aimed to investigate potential recurrence-risk biomarkers based on significant pathways for Luminal A breast cancer through gene expression profile analysis. Initially, the profiles of patients were downloaded from Cancer Genome Atlas database. differentially expressed genes (DEGs) identified using a Limma package and hierarchical clustering analysis was conducted DEGs. In addition, functional screened Kyoto Encyclopedia Genes Genomes pathway enrichment analyses rank ratio...
Abstract Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced breast cancer (LABC). However, lack efficient method to predict treatment response and prognosis limits clinical evaluation patient eligibility. Elevated lymphocyte-to-monocyte ratio (LMR) has been reported be associated with favorable in some hematology malignancies nasopharyngeal carcinoma, but not studied cancer. The purpose this study evaluate whether LMR a predictor curative impact LABC patients after...