A5025010750- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Sperm and Testicular Function
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Sexual function and dysfunction studies
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Thyroid and Parathyroid Surgery
- Prostate Cancer Treatment and Research
- Signaling Pathways in Disease
- Reservoir Engineering and Simulation Methods
- Peptidase Inhibition and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
Wuhan Union Hospital
2025
Nanjing Medical University
2012-2024
China Pharmaceutical University
2024
Daqing Oilfield General Hospital
2016-2023
Nanjing Drum Tower Hospital
2016-2023
Daqing Oilfield of CNPC
2023
C-Com Satellite Systems (Canada)
2023
Eighth Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Shandong University
2022
Lactate dehydrogenase B ( LDHB ) is a glycolytic enzyme that catalyses the conversion of lactate and NAD + to pyruvate, NADH H . Protons (H generated by promote lysosomal acidification autophagy in cancer, but how this role regulated has not been defined. In study, we identified an important post‐translational mechanism which during cancer cells. Mass spectrometry revealed protein sirtuin 5 SIRT 5) binding partner deacetylated at lysine‐329, thereby promoting its enzymatic activity....
Abstract Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs the seminal plasma of infertile males. In this study, we systematically investigated profiles males to identify that are altered during infertility and evaluate their diagnostic value. Seminal samples were obtained from 211 patients (asthenozoospermia azoospermia) 91 fertile controls. High-throughput sequencing technology was employed screen piRNA pooled healthy controls...
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC thirteen female (FBC) patients. We find has significantly lower infiltration T relative to FBC. Metastasis-related programs are more active in MBC. The activated fatty acid metabolism involved FASN related cell metastasis low immune show activation p38 MAPK lipid...
Background Advanced triple-negative breast cancer (TNBC) is prone to brain metastasis (BrM). The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it vital comprehend the behind it. Methods protein chip analysis was conducted identify any abnormal UBE2T expression in TNBC, especially BrM. Here, we used public databases and bioinformatics as well clinical samples from different cohorts investigate interrelationship between...
Natural plant products occupy a very important position in the area of cancer chemotherapy. Many triterpenoid saponins have been proved as potential agents for chemoprevention and therapy breast cancer. α-hederin, monodesmosidic saponin distributed Hedera or Nigella species, displays many biological activities. It is increasingly investigated its promising anticancer since it has shown to cytotoxicity against several types cells. However, studies α-hederin on are limited, most which focus...
Asthenozoospermia is one of the essential causes male infertility, and its incidence significantly higher in obese men. Due to complex etiology unknown pathomechanism, diagnosis treatment obesity-induced asthenozoospermia a prevalent problem reproductive medicine.This study aims explore major differential metabolites metabolic pathways seminal plasma pathological mechanisms for asthenozoospermia.We performed non-target metabolomic studies on healthy men with normal semen parameters (HN...
Suppressed gluconeogenesis and increased glycolysis are common in clear cell renal carcinoma (ccRCC). Phosphoenolpyruvate carboxykinase 1 (PCK1) is a rate-limiting enzyme. However, the role of PCK1 tumor metabolism progression remains unclear.Artificial modulation (down- upregulation) two ccRCC lines was performed to explore glycolytic phenotype growth metastasis vitro vivo. Sixty-two patients with underwent 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography. The levels lactate...
There is increasing evidence for convincing efficacy and safety of 177Lu-labled prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT) metastatic castration-resistant prostate cancer (mCRPC). However, data are not available regarding the feasibility PSMA-targeted RLT in East Asians. The present study summarized first experience with 177Lu-PSMA-I&T mCRPC China.Forty consecutive patients were enrolled from December 2019 to September 2021. Eligible received at intervals...
Lung cancer is the leading cause of cancer-related death worldwide. Aerobic glycolysis considered seventh hallmark cancer. The M2 isoform pyruvate kinase (PKM2) an important rate-limiting enzyme in glycolytic pathway, and strongly expressed several types Thus, understanding underlying mechanisms regulation PKM2 great value for targeted therapy lung cancer.Seventy-three adenocarcinoma patients were analyzed our study. expression levels by immunohistochemistry on tissues. effect small...
// Liang Shi 1,* , Tian-Song Xia Xiao-Long Wei 3,* Wenbin Zhou 1 Jinqiu Xue Lin Cheng Peipei Lou Chunlian Li Ying Wang Ji-Fu 2 Qiang Ding Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China Research Division of Clinical Pharmacology, 3 Department Pathology, Cancer Shantou University College, Shantou, * These authors have contributed equally to this work Correspondence to: Ding, email: Wei, Keywords : estrogen receptor, RNPC1, mRNA...
Purpose: Gastric adenosquamous carcinoma (ASC) is a rare pathological type with poorly understood clinicopathological features.The purpose of this study to identify the characteristics gastric ASC patients.Methods: Using Surveillance, Epidemiology, and End Results (SEER) database (2000 2014), patients (N=93) or adenocarcinoma (AC) (N=41794) stomach were included.The epidemiology, tumor features, treatment, outcomes between these two groups compared. Results:The incidences from 1983 2014...
// Peipei Lou 1, * , Chunlian Li Liang Shi Tian-Song Xia 1 Wenbin Zhou Jing Wu Xujie Xiaoxia Ying Wang Ji-Fu Wei 2 Qiang Ding Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, City, Province, 210000, China Research Division of Clinical Pharmacology, These authors have contributed equally to this work Correspondence to: Wei, email: weijifu@hotmail.com Ding, dingqiang@njmu.edu.cn Keywords: progesterone receptor, RNPC1, mRNA stability, breast cancer,...
// Yulin Liu 1, * , Fan Xiang Yongming Huang 1 Liang Shi 2 Chaojie Hu Yiming Yang Di Wang Nan He Kaixiong Tao Ke Wu Guobin Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan 430022, China Clinical Laboratory, These authors have contributed equally to this work Correspondence to: Wang, email: guobinwanguh@163.com Wu, wuke_2015@yeah.net Keywords: interleukin-22, colon cancer, aerobic glycolysis, proliferation,...
PSMA-negative neuroendocrine prostate cancer (NEPC) is likely to be a lethal subtype of (PCa) with limited clinical diagnostic and therapeutic options. High expression neurotensin receptor 1 (NTR1) associated differentiation PCa, which makes NTR1 potential target for NEPC. In this study, NTR1-targeted tracer <sup>68</sup>Ga-DOTA-NT-20.3 was synthesized evaluated by determining its affinity androgen-dependent (LNCap) androgen-independent (PC3) xenografts....
TIPARP (TCDD-inducible poly-ADP-ribose polymerase), a mono-ADP-ribosyltransferase and transcriptional repressor of aryl hydrocarbon receptor (AHR), was one the potential therapeutic targets for human cancers identified by CRISPR-Cas9 screens recently. Studies about on are scarce till now, most which just focus expressions, while functions have not been widely reported yet. Moreover, prognostic significance value breast cancer is also uncertain.The present study performed to comprehensively...
Cell division cycle protein (CDC20) has been observed to be expressed higher in various kinds of human cancers and was associated with poor prognosis. However, studies on role CDC20 breast cancer are seldom reported till now, most which not systematic conclusive. The present study performed analyze the expression pattern, potential function, distinct prognostic effect using several online databases including Oncomine, bc-GenExMiner, PrognoScan, UCSC Xena. To verify results from databases, we...
BACKGROUND: Breast cancer is a worldwide leading cause of mortality and it associated with numerous tumor suppressor genes oncogenes. Growing evidence exists that different KLFs play pivotal roles in human malignancies. However, the function breast development has remained uncovered. OBJECTIVE: To explore potential prognostic biomarkers among cancer. METHODS: In present study, by using multiple large open databases, such as Oncomine database, Kaplan-Meier Plotter, bc-GenExMiner online...
Vaccination is one of the best ways to control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic. Among various SARS-CoV-2 vaccines approved for use, BBIBP-CorV inactivated vaccine has been widely used in 93 countries. In order understand deeply protective mechanism vaccine, which retains all antigenic components live virus, analysis humoral responses triggered by multiple proteins necessary. this research, antibody were generated with 6 selected recombinant and 68...
BackgroundThyroid dysfunction is common in critical illness and may influence prognosis. However, the value of TSH patients with severe diseases remains unclear. The aim this study was to investigate association between clinical prognosis critically ill patients. Methods: This retrospective identified who were admitted ICU Medical Information Mart for Intensive Care (MIMIC-IV) database (version 2.2). A total 6432 divided into four groups based on quartiles (Q1, <0.92 mIU/L; Q2, 0.92–1.07 Q3,...