A5029189022- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Advanced Nanomaterials in Catalysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Metal complexes synthesis and properties
- Angiogenesis and VEGF in Cancer
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Advanced Computational Techniques and Applications
- Cancer-related Molecular Pathways
Nanjing Medical University
2016-2025
Jiangyin People's Hospital
2025
Xuzhou Medical College
2025
University of California, Los Angeles
2024-2025
Samueli Institute
2025
Jiangnan University
2023-2024
Huadong Hospital
2009-2024
Fudan University
2024
China Pharmaceutical University
2024
Institute of Chinese Materia Medica
2021
This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .
Abstract The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate therapeutic targeting tumor microenvironment (TME) reprogramming, here we develop biocompatible, non-covalent channel-type nanoparticles (CNPs) that fabricated through host-guest complexation self-assemble mannose-modified γ-cyclodextrin (M-γ-CD) Regorafenib (RG), RG@M-γ-CD CNPs. In addition to its carrier...
Extracellular vesicles (EVs) attract much attention in liver pathology because they regulate cell–cell communication and many pathophysiological events by transferring their cargos. Monitoring understanding the vivo fate therapeutic capacity of these EVs is critical for development optimization EV-based diagnosis therapy. Herein, we demonstrate use an aggregation-induced emission luminogen, DPA-SCP, real-time tracking derived from human placenta-derived mesenchymal stem cells (MSCs) effects...
Urinary tract infections (UTIs), common bacterial in communities and medical facilities, are mainly mediated by FimH. The glycan sites of the uromodulin protein play a crucial role protecting against UTIs interacting with A bioinspired approach using glycan-FimH interactions may effectively reduce bacteria through an antiadhesive mechanism, thereby curbing resistance. However, typical therapy alone fails to address excessive reactive oxygen species inflammatory response during UTIs. To...
Abstract Stimulating photosensitizers (PS) by Cerenkov radiation (CR) can overcome the light penetration limitation in traditional photodynamic therapy. However, separate injection of radiopharmaceuticals and PS cannot guarantee their efficient interaction tumor areas, while co‐delivery radionuclides face problem nonnegligible phototoxicity normal tissues. Here, we describe a 131 I‐labeled smart photosensitizer, composed pyropheophorbide‐a (photosensitizer), diisopropylamino group...
Interest in targeted cancer therapies with fewer side effects has increased recent years.
Overexpression of fibroblast activation protein (FAP) in cancer-associated fibroblasts a wide variety tumors enables highly selective targeting strategy using FAP inhibitors (FAPIs). Quinoline-based FAPIs labeled with radionuclides have been widely developed for tumor-targeted nuclear medicine imaging. However, the short retention time at tumor site limits their application radionuclide therapy. In this study, novel FAPI-04 dimer was synthesized and to prolong imaging To prepare complex,...
Abstract Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) closely associated with FAO both cellular processes and disease conditions. Pellino 1 (Peli1), an E3 ligase containing RING-like domain, plays crucial role catalyzing polyubiquitination various substrates. In this study, we aimed to investigate the involvement HNF4α its ubiquitination, facilitated by Peli1,...
Joint injury is associated with risk for development of osteoarthritis (OA). Increasing evidence suggests that activation fibrinolysis involved in OA pathogenesis. However, the role fibrinolytic pathway not well understood. Here we showed pathway, which includes plasminogen/plasmin, tissue plasminogen activator (tPA), urokinase (uPA) and uPA receptor (uPAR), were dysregulated human joints. Pharmacological inhibition plasmin attenuated progression a destabilization medial meniscus (DMM) mouse...
Abstract Background MRI-derived apparent diffusion coefficient (ADC) and contrast-enhancement (CE) may represent non-invasive biomarkers to evaluate microstructural tissue changes histopathological immune cell infiltration induced by checkpoint inhibitors (ICI). Methods 125 lesions across 93 patients were analyzed. ADC (reflecting water diffusivity) CE T1-subtraction maps blood-brain barrier permeability) tumor values used for bivariate histograms of CE, quantify voxel fractions belonging...
Liver transplantation (LT) remains the primary treatment for irreversible liver failure. However, challenges in organ preservation, particularly ischemia-reperfusion injury and donor vulnerability, contribute to poor post-transplant outcomes.[1,2] The accumulation of reactive oxygen species (ROS) exacerbates these issues, leading inflammation, tissue damage, impaired graft function.[3] Ceria nanoparticles have gained attention their antioxidant, antibacterial, antifibrotic properties...
Severe intra-abdominal infections are life-threatening conditions and a significant challenge for surgeons. This article presents case of an elderly patient with severe infection complicated by anastomotic leak. had experienced prolonged sepsis multiple surgical traumas. Upon admission to our department, exploratory surgery revealed extensive bowel edema adhesions, leak, abdominal contamination infection. In accordance the principles damage control surgery, leak was exteriorized, abdomen...
Abstract Objective To characterize MRI changes of brain metastases (BM) following laser interstitial thermal therapy (LITT), particularly in lesions exhibiting durable response or early progression. Materials and methods Longitudinal scans from patients with LITT-treated BM were retrospectively analyzed. Treatment was categorized as response, long-term disease control (i.e., stable at 1 year), < year, progression year. Volumetric diffusion after LITT analyzed for each subregion...
This study sought to evaluate [(99m)Tc(HYNIC-Galacto-RGD2)(tricine)(TPPTS)] ((99m)Tc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-methylamide)]]2 (SAA 7-amino-L-glycero-L-galacto-2,6-anhydro-7-deoxyheptanamide, and PEG2 3,6-dioxaoctanoic acid); TPPTS trisodium triphenylphosphine-3,3',3″-trisulfonate) as a new radiotracer for tumor imaging. was prepared via the copper(I)-catalyzed 1,3-dipolar azide-alkyne Huisgen...
Transarterial chemoembolization (TACE) is an image-guided locoregional therapy used for the treatment of patients with primary hepatocellular carcinoma (HCC). However, conventional TACE formulations such as epirubicin-lipiodol emulsion are rapidly dissociated due to instability emulsion, resulting in insufficient local drug concentrations target tumor. To overcome these limitations, we biodegradable Idarubicin loaded microspheres (BILMs), which were prepared from gelatin and carrageenan...
A series of half-sandwich ruthenium complexes containing quinoline derivative ligands was synthesized, which had excellent antitumor toxicity toward a variety cell lines and could localize lysosomes. The damage lysosomes promotes the release cathepsin B initiates downstream apoptotic cascade signals. increase in reactive oxygen species (ROS) caused by decrease mitochondrial membrane potential (ΔΨm) synergistically amplified degree In addition, complex inhibit transfer clone formation. vivo...
Purpose:The purpose of this study was to evaluate the capability u-SPECT-II/CT monitor progression breast cancer lung metastasis using 99m Tc-3P-RGD 2 as a radiotracer. Methods:The model established by tail-vein injection x 10 5 -1.5 6 MDA-MB-231 cells into each athymic nude mouse.SPECT/CT studies were performed at specified time after inoculation cells.Histological staining used further confirm presence metastases.Results: We found that both and tumor cell load had significant influence on...
The CTX-SLB-MSN targeted nanoplatform has a substantial potential in combinational therapy against colorectal cancer.
There is increasing evidence for convincing efficacy and safety of 177Lu-labled prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (PRLT) metastatic castration-resistant prostate cancer (mCRPC). However, data are not available regarding the feasibility PSMA-targeted RLT in East Asians. The present study summarized first experience with 177Lu-PSMA-I&T mCRPC China.Forty consecutive patients were enrolled from December 2019 to September 2021. Eligible received at intervals...
Preventing tumor recurrence is the most important target for cancer treatment. However, current effective and advanced technology relies on use of near-infrared region (NIR), equipment NIR-I NIR-II fluorescence imaging technique-based fluorescent-guided surgery expensive complicated to operate. Here, we report a safe strategy an organic-inorganic hybrid gold nanoparticle-based novel smart probe (Au@PDA-ss-PEGm NPs) which appropriate photoacoustic (PAI) plasmonic photothermal therapy (PPTT)...