A5100660914- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Cerebrovascular and Carotid Artery Diseases
- Effects of Radiation Exposure
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Venous Thromboembolism Diagnosis and Management
- Boron and Carbon Nanomaterials Research
- MRI in cancer diagnosis
- Advanced Breast Cancer Therapies
- Vascular Procedures and Complications
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- T-cell and B-cell Immunology
- Boron Compounds in Chemistry
- Occupational and environmental lung diseases
- Nonmelanoma Skin Cancer Studies
- Ion Transport and Channel Regulation
- Lung Cancer Diagnosis and Treatment
Zunyi Medical University
2024-2025
Ningxia Medical University
2013-2024
Nanjing Drum Tower Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2023
Ningxia Medical University General Hospital
2019-2022
Beijing Luhe Hospital Affiliated to Capital Medical University
2020-2022
Nanjing University of Chinese Medicine
2019
National Natural Science Foundation of China
2017
China-Japan Friendship Hospital
2017
University of South Florida
2014
This study presents a new type of boron carrier for neutron capture therapy that integrates imaging, lung cancer targeting drug and carborane, showcases an impressive therapeutic efficacy against tumors both in vitro vivo .
Pulmonary fibrosis (PF) is a common and multidimensional devastating interstitial lung disease. The development of novel more effective interventions for PF an urgent clinical need. A previous study has found that miR-181a-5p plays important role in the PF, human amniotic mesenchymal stem cells (hAMSCs) exert potent therapeutic potential on PF. However, whether hAMSCs act by delivering its detailed mechanism still remain unknown. Thus, this was designed to investigate underlying possible...
Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction vascular bed and hypoxia microenvironment, mechanisms underpinning its pathogenesis however remain elusive. The dysregulated expression nicotinamide adenine dinucleotide phosphate (NADPH)-oxidases superoxide generation by vasculatures have significant implications hypoxia-induced PH.In this study, involvement NADPH oxidase subunit 4 (NOX4) arteriolar...
Abstract: The C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me), one the synthetic triterpenoids, has been found to have potent anti-inflammatory and anticancer properties in vitro vivo. However, its usefulness mitigating radiation-induced lung injury (RILI), including inflammation fibrosis, not tested. aim this study was explore therapeutic effect CDDO-Me on RILI mice underlying mechanisms. Herein, we that administration improved histopathological score, reduced...
WAC-antisense RNA1 (WAC-AS1) is a newly identified long non-coding RNA (lncRNA) implicated in the prognosis and development of few types tumors. However, correlations WAC-AS1 with immune infiltration patient pan-cancer remain unclear. In present study, we aimed to investigate prognostic value immunological functions across 33 different cancers.To potential oncogenic roles WAC-AS1, bioinformatics analyses were performed using Cancer Genome Atlas (TCGA) Genotype Tissue-Expression (GTEx)...
Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have become the standard care of patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC), development acquired resistance is inevitable. A secondary mutation threonine 790 (T790M) associated approximately half cases resistance. Strategies or agents to overcome this type are still limited. In study, enhanced antitumor effect AT-101, a-pan-Bcl-2 inhibitor, on gefitinib was explored in NSCLC T790M...
Background: Normal fusion of the upper lip and primary palate is a complex process involving series characteristic orderly regulated cellular events. Cleft with or without (CL/P), one most common congenital malformations, may be induced by abnormalities in any these However, less known about precise regulatory palate. Methods: Lambdoidal junction tissues mice from embryonic days 10.5, 11.5, 12.5— three key stages—were acquired for RNA sequencing. Results: Gene expression profiles distinct...
Dysregulation of cell cycle progression (CCP) is one the hallmarks cancer. Here, our study aimed at developing a CCP-derived gene signature for predicting high-risk population hepatocellular carcinoma (HCC). Our retrospectively analyzed transcriptome profiling and clinical information HCC patients from The Cancer Genome Atlas (TCGA) International Consortium (ICGC) projects. Uni- multivariate cox regression models were conducted identifying which cancer risk factors HCC. was developed with...
Gliomas are the most common malignant brain tumors, with complicated etiology and poor prognosis. However, there is still a lack of specific biomarkers for diagnosis, treatment prognosis assessment glioma patients. Hence, purpose this study was to screen prognostic therapeutic interventions in gliomas.
Infantile hemangiomas are the most common benign childhood tumors and can occur on any part of human body. Sclerosing agents used in early stage treatment infantile hemangioma. Sometimes a lip defect remains after sclerosing agent treatment. We developed simple technique to repair defects. The authors performed transposition mucosal flap autologous fat transplantation surgery patients who had defects caused by agents. was transposed 90° from intraoral labial mucosa vermilion defect....
Objective To compare the diagnostic performance of multi-contrast atherosclerosis characterization (MATCH) and magnetization-prepared rapid acquisition gradient-echo (MPRAGE) for detection IPH with histologic analysis as reference standard. Methods Thirty individuals were collected in this study. They diagnosed to have carotid stenosis>50% by ultrasound scheduled endarterectomy from 2014 2015. 3 T MR examinations using MPRAGE, MATCH 3D TOF performed these patients. Axial images...
Objective To explore the feasibility of delineation atherosclerotic plaque in carotid artery using compressed sensing three dimensional motion-sensitized driven equilibrium prepared rapid gradient echo (CS-3D MERGE) technique. Methods Twenty-three patients who underwent endarterectomy (CEA) were enrolled prospectively. In all patients, bilateral arteries scanned by CS-3D MERGE and contrast-enhanced MR angiography (MRA) simultaneously. Image quality images was scored. Images from...
Objective To explore the significance of comprehensive treatment including anticoagulation, inferior vena cava filter implantation, mechanical thrombectomy, iliac vein angioplasty and stent placement catheter-directed thrombolysis(CDT) in acute femoral thrombosis on basis left compression. Methods In this study 61 patients were enrolled at Beijing Luhe Hospital, Capital Medical University between Mar 2013 2019 anticoagulation combined with CDT group group. Short-term venous...
Angiotensin I, II (AI, AII) and aldosterone are unstable in plasma specimens at room temperature, making it difficult for collect samples remote regions centralized collaborative studies. Here we introduce a stable storage method which do not require cold conditions..Acetonitrile was added to the 60%, then supernatants were kept 4°C temperature 0, 1, 2, 3, 10 30 days. AI, AII extracted analyzed by chemiluminescence immunoassays.AI, well retained supernatant under this method. The intra-...