A5100341374- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Tea Polyphenols and Effects
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Congenital Anomalies and Fetal Surgery
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Transplantation: Methods and Outcomes
- Orthopedic Infections and Treatments
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Renal Transplantation Outcomes and Treatments
- Spine and Intervertebral Disc Pathology
- Parasitic infections in humans and animals
- Lung Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
Xijing Hospital
2009-2025
Air Force Medical University
2009-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Qingdao University
2019-2025
Central South University
2014-2025
Xiangya Hospital Central South University
2014-2025
Yuhuangding Hospital
2025
Sichuan University
2009-2024
West China Hospital of Sichuan University
2016-2024
Hokkaido University
2024
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1 million people worldwide annually, few effective treatments available. Sintilimab, a recombinant human IgG4 monoclonal antibody that binds to programmed cell death (PD-1), combination with chemotherapy, has demonstrated promising efficacy. Objective To compare overall survival of patients unresectable locally advanced or metastatic gastric who were treated sintilimab chemotherapy vs placebo chemotherapy....
Background De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor (AT1R-abs) have been associated with antibody-mediated rejection (AMR) decreased graft survival as well cellular-mediated (CMR) early onset of microvasculopathy in heart transplantation. The aim our study was to determine the impact anti–AT1R-ab anti–donor HLA–specific antibody (DSA) on clinical outcomes. Methods Pretransplant posttransplant sera from 200 recipients transplanted...
Abstract Hepatocellular carcinoma (HCC) is a common malignant tumor with high recurrence rate and poor prognosis. Long intergenic nonprotein coding RNA 942 (LINC00942) reported to be related ferroptosis the immune response in HCC serves as an oncogene various cancers. This research aimed explore contribution of LINC00942 progression. Functional assays were used evaluate functional role vitro vivo. Mechanistic conducted assess association insulin-like growth factor 2 mRNA binding protein 3...
The aims of this study were to determine the level donor-specific antibody (DSA) that allows for successful transplantation after desensitization with IVIG and rituximab identify patients at risk antibody-mediated rejection (AMR).Pre- posttransplant sera from 16 DSA before tested. Strength was determined by single antigen Luminex bead assay results expressed as standard fluorescence intensity (SFI). T-cell flow crossmatch mean channel shifts (MCS). AMR biopsy C4d deposition.Six had negative...
Activation of pro-inflammatory and pro-angiogenic pathways in the retina bone marrow contributes to pathogenesis diabetic retinopathy. We identified miR-15a as key regulator both through direct binding inhibition central enzyme sphingolipid metabolism, ASM, growth factor, VEGF-A. was downregulated cells. Over-expression downregulated, upregulated ASM VEGF-A expression retinal In addition effects, migration vascular repair function impaired inhibitor-treated circulating angiogenic cells...
Currently, propranolol is the most preferred systemic therapy for problematic infantile hemangiomas (IHs). However, side effects such as bronchial hyperreactivity may be intolerable. The aim of this study was to evaluate frequency, risk factors and management intolerable (ISEs) during therapy. In total, 1260 children were studied. incidence ISEs 2.1% (26 patients). Severe sleep disturbance common reason cessation, accounting 65.4% cases. 23 3 patients received atenolol prednisolone...
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in world. Microvascular invasion (MVI) a major risk factor for survival outcomes intrahepatic metastasis after resection patients with HCC. Relevant English literatures retrieved using PubMed on research progress MVI HCC were reviewed. For patients, especially those MVI, it very important to develop comprehensive sequential treatment plan support long-term patients. This manuscript reviewed analyzed factors...
De novo and acquired resistance are major impediments to the efficacy of conventional targeted cancer therapy. In unselected gastric (GC) patients with advanced disease, trials combining chemotherapy an anti-EGFR monoclonal antibody have been largely unsuccessful. effort identify biomarkers so as better select for such trials, we screened secretome chemotherapy-treated human GC cell lines. We found that levels CGA, α-subunit glycoprotein hormones, were markedly increased in conditioned media...
Abstract: Plumbagin (PLB), an active naphthoquinone compound, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of PLB for treatment pancreatic cancer is unclear. This study aimed to examine cell killing investigate human PANC-1 BxPC-3 cells. The results showed that exhibited inducing on cycle arrest cells via modulation regulators including CDK1/CDC2, cyclin B1, D1, p21 Waf1/Cip1, p27 Kip1, p53. concentration- time-dependently increased...
Diabetic retinopathy (DR) is a complication secondary to diabetes and the number one cause of blindness among working age individuals worldwide. Despite recent therapeutic breakthroughs using pharmacotherapy, cure for DR has yet be realized. Several clinical trials have highlighted vital role dyslipidemia plays in progression DR. Additionally, it recently been shown that activation Liver X receptor (LXRα/LXRβ) prevents diabetic animal models. LXRs are nuclear receptors play key roles...
To investigate the incidence and pattern of traumatic spinal fractures (TSFs) associated cord injury (SCI) resulting from motor vehicle collisions (MVCs). This was a cross-sectional study. We retrospectively reviewed 698 patients with TSFs MVCs admitted to our university-affiliated hospitals 2001 2011. The were summarized respect different age groups, fracture levels, role patients. There 464 males (66.5%) 234 females (33.5%) aged 40.5 ± 13.8 years old. most common roles in car drivers (189,...
In the present study, effects of taxifolin, a plant flavonoid, on lipid, apolipoprotein B (apoB), and A-I (apoA-I) synthesis secretion were determined in HepG2 cells. Pretreatment cells with (±)-taxifolin led to an inhibition cholesterol dose- time-dependent manner, 86 ± 3% at 200 μM observed within 24 h. As mechanism underlying this inhibitory effect, taxifolin was shown inhibit activity HMG-CoA reductase by 47 7%. addition, cellular esterification, triacylglycerol phospholipid syntheses,...
There is no consensus about the best method of achieving equal leg lengths at total hip arthroplasty (THA) in patients with Crowe type-IV developmental dysplasia (DDH). We reviewed our experience a consecutive series who underwent THA for this indication.We retrospectively 78 (86 THAs) DDH, including 64 women and 14 men, minimum follow-up two years. The mean age time surgery was 52.2 years (34 to 82). subdivided DDH into major types according number dislocated hips, further categorised them...
Chemotherapy has substantially improved gastric cancer (GC) patient outcomes in the past decades. However, development of chemotherapy resistance become major cause treatment failure. Although numerous molecules have been implicated GC chemoresistance, its pathological mechanisms are still unclear. Here, we found that integrin subunit alpha 2 (ITGA2) is upregulated chemoresistant cells and increased ITGA2 levels correlated with poor prognosis patients who received chemotherapy....
Introduction Carbohydrates, which make up 20 to 25% of tea beverages, are responsible for their flavor and bioactivity. Carbohydrates pu-erh change during microbial fermentation require further research. In this study, we examined the carbohydrate metabolism expression carbohydrate-active enzyme genes leaves with Aspergillus luchuensis . Methods Widely targeted metabolomics analysis, high-performance anion-exchange chromatography measurements, transcriptomics were used in study. Results...
<title>Abstract</title> Osteoporosis is the most common form of bone disease and RANKL/RANK/OPG has been widely demonstrated to be a critical protein for metabolism. Previous studies suggested that flavonoids played an obligatory role in inhibition process osteoclast differentiation induced by RANKL. However, detailed mechanisms were still unknown. Eucommia ulmoides popular herb used treat diseases traditional medicine, which play important role. Thus, present study, specially selected...
The effects of different stents and morphology the stenosis on hemodynamic depression (HD) in-stent restenosis (ISR) are unclear after carotid artery stenting(CAS). 142 patients were retrospectively enrolled stratified into straight stent(SS) tapered stent(TS), further according to compare differences in final events. Logistic analysis was used determine risk factors for occurrence HD. TS had a lower incidence post-procedural HD (38.8% vs 60.0%, P=0.012) 1-year ISR (1.5% 8.0%, P=0.078). In...
Early predicting response before neoadjuvant chemotherapy (NAC) is crucial for personalized treatment plans locally advanced breast cancer patients. We aim to develop a multi-task model using multiscale whole slide images (WSIs) features predict the NAC more finely. This work collected 1,670 training and validation sets, internal testing external prospective sets of weakly-supervised deep learning-based (DLMM) in pCR NAC. Our approach models two-by-two feature interactions across scales by...