A5100672247- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Pulmonary Hypertension Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Carbon dioxide utilization in catalysis
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- T-cell and B-cell Immunology
- Boron Compounds in Chemistry
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Covalent Organic Framework Applications
- Hepatitis B Virus Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
University of North Texas
2023-2025
Lanzhou University
2016-2024
Jianghan University
2023-2024
First Hospital of Lanzhou University
2019-2023
Fu Wai Hospital
2018-2023
Second Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Hangzhou Children's Hospital
2022
University of Lausanne
2020-2021
Abstract Memory CD8 T cells can provide long-term protection against tumors, which depends on their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain cellular fitness. Specifically, memory engage oxidative phosphorylation fatty acid oxidation fulfill demands. In contrast, tumor-infiltrating lymphocytes (TILs) display severe defects, may underlie functional decline. Here, we show that overexpression of proliferator-activated receptor gamma coactivator...
The present study aims to investigate the antitumor effect and possible mechanisms of chlorin e6 (Ce6)-mediated sono-photodynamic therapy (Ce6-SPDT) on murine 4T1 mammary cancer cells in vitro.Cellular uptake intracellular distribution Ce6 were detected by flow cytometry confocal microscope. Cells after loading with 1 μg/mL exposed ultrasound at 1.0 MHz for up minute an intensity 0.36 W/cm2 laser light total radiation dose 1.2 J/cm2. Cell viability clonogenicity determined MTT assay colony...
Converting CO2 to high‐value fine chemicals represents one of the most promising approaches combat global warming and subsequently achieve a sustainable carbon cycle. Herein, we contribute an organoboron functionalized ultra‐thin metal‐organic nanosheet (MON), termed TCPB‐Zr‐NS, featuring abundance exposed Lewis acidic B formate sites, which can effectively promote conversion upon addition basic o‐phenylenediamines. Compared with prototypical 3D analogue TCPB‐Zr‐3D, resultant TCPB‐Zr‐NS...
Converting CO2 to high‐value fine chemicals represents one of the most promising approaches combat global warming and subsequently achieve a sustainable carbon cycle. Herein, we contribute an organoboron functionalized ultra‐thin metal‐organic nanosheet (MON), termed TCPB‐Zr‐NS, featuring abundance exposed Lewis acidic B formate sites, which can effectively promote conversion upon addition basic o‐phenylenediamines. Compared with prototypical 3D analogue TCPB‐Zr‐3D, resultant TCPB‐Zr‐NS...
Several new group 4 metal amide complexes with recently developed constrained-geometry carborane ligands, [η5:σ-Me2A(C9H6)(C2B10H10)]M(NR2)2 and [η5:σ-Me2A(C5H4)(C2B10H10)]M(NR2)2 (A = C, Si; M Ti, Zr; R Me, Et), were prepared in good yield via amine elimination reactions of M(NR2)4 the corresponding neutral ligands toluene. Treatment 2.5 equiv Me2NH·HCl or Me3N·HCl led to high yields chloride complexes, [{η5:σ-Me2A(C9H6)(C2B10H10)}ZrCl(μ-Cl)1.5]2- Si), which could also be from an equimolar...
BACKGROUNDDifferent types of periampullary diverticulum (PAD) may differentially affect the success endoscopic retrograde cholangiopancreatography (ERCP) cannulation, but clinical significance two current PAD classifications for cannulation is limited.
Oncogenesis and tumor development have been related to oxidative stress (OS). The potential diagnostic utility of OS genes in hepatocellular carcinoma (HCC), however, remains uncertain. As a result, this work aimed create novel related-genes signature that could be used predict the survival HCC patients screen drugs might for treatment.
Acute pancreatitis (AP) is a pancreatic inflammatory disease that varies greatly in course and severity. To further the understanding of pathology AP, we carried out data-independent acquisition-based proteomic analyses using proteins extracted from plasma patients with severe acute (SAP) (experimental group) healthy volunteers (control group). Compared to control group, there were 35 differentially expressed (DEPs) SAP. Of those, expression levels for 6 significantly increased, 29...
Gallbladder drainage plays a key role in the management of acute cholecystitis (AC) patients. Percutaneous transhepatic gallbladder (PTGBD) is commonly used while endoscopic naso-gallbladder (ENGBD) serves as an alternative. A single center, prospective randomized controlled trial was performed. Eligible AC patients were randomly assigned to ENGBD or PTGBD group. Randomization computer-generated list with 1:1 allocation. All received cholecystectomy 2-3 months after drainage. The primary...
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Abstract Photodynamic therapy (PDT) is a promising method for neoplastic and nonneoplastic diseases. In this study, we utilized sinoporphyrin sodium (DVDMS) as sensitizer combined with light to investigate its cytotoxic effect on different cell lines. For purpose, chose bovine serum albumin (BSA) model explore the mechanism of PDT-induced death at molecular level. Our findings indicated that treatment significantly suppressed survival. Fluorescence spectroscopy revealed strong interaction...
Abstract Background Lack of forward-viewing endoscopy experience impairs training in endoscopic retrograde cholangiopancreatography (ERCP). We evaluated the effect ERCP mechanical simulator (EMS) practice on performance by surgical trainees. Patients and methods 12 trainees without were randomly allocated to non-EMS (n = 6) programs or EMS with coaching 20 hours supervised practice. All then received hands-on clinical training. Trainers provided verbal instructions assistance, took over if...
Hepatocellular carcinoma (HCC) is a common immunogenic malignant tumor. Although the new strategies of immunotherapy and targeted therapy have made considerable progress in treatment HCC, 5-year survival rate patients still very low. The identification prognostic signatures exploration immune microenvironment are crucial to optimization improvement molecular strategies. We studied potential clinical benefits inflammation regulator miR-93-3p mined its target genes. Weighted gene co-expression...
Most of study regarding periampullary diverticulum (PAD) impact on endoscopic retrograde cholangiopancreatography (ERCP) therapy for choledocholithiasis based data from one endoscopy center and lacked to compare the clinical characteristic with PAD different geographical patients.To characteristics between two regional centers analyze impacts ERCP methods patients PAD.Patients seen in (The First Hospital Lanzhou University, Lanzhou, Gansu Province, China, Kyoto Second Red Cross Hospital,...
Colon adenocarcinoma (COAD) is the most common pathological subtype of colon cancer with a high degree malignancy. Cuproptosis newly discovered copper‑dependent cell death pattern distinguished from all other known programmed death. Hence, it can be used as potential therapeutic target for cancer. The present study aimed to clarify relationship between cuproptosis and prognosis COAD. variations 12 cuproptosis‑associated genes based on 623 patients COAD were comprehensively identified. It was...