A5101977067- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism and Genetic Disorders
- Acute Myocardial Infarction Research
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Pediatric Hepatobiliary Diseases and Treatments
- Coronary Interventions and Diagnostics
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Nutrition and Health in Aging
- Photosynthetic Processes and Mechanisms
- Amino Acid Enzymes and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Eicosanoids and Hypertension Pharmacology
- Cardiac Arrest and Resuscitation
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Fibroblast Growth Factor Research
- Cardiomyopathy and Myosin Studies
Capital Medical University
2025
Huadong Hospital
2025
Fudan University
2025
Lanzhou University
2018-2024
First Hospital of Lanzhou University
2020-2024
Taichung Veterans General Hospital
2021-2024
Nanjing Medical University
2024
Taipei Veterans General Hospital
2019-2023
National Yang Ming Chiao Tung University
2019-2023
Taipei Medical University
2023
Microbial trimethylamine (TMA)-lyase activity promotes the development of atherosclerosis by generating TMA, precursor TMA N-oxide (TMAO). TMAO is well documented, but same can not be said TMA-producing bacteria. This work aimed to identify genera in human intestinal microbiota. We retrieved genomes human-associated microorganisms from Human Microbiome Project database comprising 1751 genomes, Unified Gastrointestinal Genome collection consisting 4644 gut prokaryotes, recapitulated 4930...
Trimethylamine N-oxide (TMAO) is a metabolite originated from bacterial metabolism of choline-rich foods. Evidence suggests an association between TMAO and atherosclerosis, but the relationship endothelial progenitor cells (EPCs) remains unclear. This study aimed to identify concentrations, circulating EPCs, function in patients with stable angina. Eighty-one angina subjects who underwent coronary angiography were enrolled. The EPCs flow-mediated vasodilation (FMD) measured evaluate...
The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ the main determinant of final acyl chain composition mitochondrial-specific phospholipid, cardiolipin. To date, a detailed characterization endogenous has only been performed yeast. Further, why given BTHS-associated missense mutation impairs function determined yeast model this human disease. Presently, tafazzin harboring individual BTHS at evolutionarily conserved residues identified seven distinct...
Mitochondrial carriers (MCs) mediate the passage of small molecules across inner mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized reactions. Despite MCs representing largest family solute in mammals, most have not been subjected to a comprehensive investigation, limiting our understanding their metabolic contributions. Here, we functionally characterize SFXN1, member non-canonical, sideroflexin family. We find that an integral IMM protein with uneven...
Tinnitus is considered a neurological disorder affecting both auditory and nonauditory networks. This study aimed to investigate the structural brain covariance network in tinnitus patients analyze its altered topological properties. Fifty three primary 67 age- sex-matched healthy controls (HCs) were included. Gray matter volume (GMV) of each participant was extracted using voxel-based morphometry, group-level (SCN) constructed based on GMV participant, graph theoretic analyses performed...
ABSTRACT Background The mechanism underlying chronic drug‐induced liver injury (DILI) remains unclear. Immune activation is a common feature of DILI progression and closely associated with metabolism. We explored the immunometabolic profile potential progression. Methods Plasma peripheral blood mononuclear cells from patients were analyzed using multiplex immunoassays untargeted metabolomics to reveal their profile. effects mechanisms DILI‐related metabolite on acute or induced by LPS CCl 4...
Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across mitochondrial inner membrane, an activity that is essential oxidative phosphorylation (OXPHOS). Mutations in or dysregulation ANTs associated with progressive external ophthalmoplegia, cardiomyopathy, nonsyndromic intellectual disability, apoptosis, and Warburg effect. Binding partners human have not been systematically identified. The absence such information has prevented a detailed molecular...
The phospholipid cardiolipin has pleiotropic structural and functional roles that are collectively essential for mitochondrial biology. Yet, the molecular details of how this lipid supports structure function proteins protein complexes poorly understood. To address property cardiolipin, we use adenosine 5'-diphosphate/adenosine 5'-triphosphate carrier (Aac) as a model. Here, have determined is critical both tertiary quaternary assembly major yeast Aac isoform Aac2 well its conformation....
Elevated circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Early control LDL-C to prevent ASCVD later in life important. The Taiwan Society Lipids and Atherosclerosis association with the other seven societies developed this new lipid guideline focusing on subjects without clinically significant ASCVD. In for primary prevention, recommended target based stratification. A healthy lifestyle recommendations foods,...
Abstract Atherosclerosis (AS) is one of important events involving in the pathological process coronary artery disease. Many traditional Chinese medicines have been widely used for treatment AS. Previous studies demonstrated that Ilexgenin A (IA) obtained from Ilex hainanensis Merr. could improve AS development. However, its underlying mechanism still unknown. This study was conducted to explore possible targets and mechanisms anti‐atheroclerosis effect IA. The results showed IA...
ABSTRACT Airway hydration and ciliary function are critical to airway homeostasis dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach the amoeba Dictyostelium discoideum identify protectors smoke. Members of mitochondrial ADP/ATP transporter family adenine nucleotide translocase (ANT) protective against smoke human bronchial epithelial cells. Gene...
Aims: Trimethylamine-N-oxide (TMAO) is a metabolite generated from dietary choline, betaine, and l-carnitine, after their oxidization in the liver. TMAO has been identified as novel independent risk factor for atherosclerosis through induction of vascular inflammation. However, effect on neointimal formation response to injury remains unclear. Results: This study was conducted using murine model acutely disturbed flow-induced induced by partial carotid artery ligation. 3,3-Dimethyl-1-butanol...
Bispecific antibodies have become important formats for therapeutic discovery. They allow potential synergy by simultaneously engaging two separate targets and enable new functions that are not possible to achieve using a combination of monospecific antibodies. Antagonistic dominate drug discovery today, but only limited number agonistic (i.e. those activate receptor signaling) been described. For receptors formed components, both these components may be required signaling. As such,...
Background Uric acid is the end product of purine metabolism. Previous studies have found that serum uric (SUA) levels are associated with total cancer risk. However, due to dual effect on cancer, relationship between SUA and most specific-site remains unclear. Aim To investigate associations incidence hepatobiliary-pancreatic cancer. Methods In this prospective cohort study, 444462 participants free from UK Biobank were included. The measured at baseline, was determined by contacting...
Endocrine fibroblast growth factors (FGFs) require Klotho transmembrane proteins as necessary co-receptors to activate FGF receptor (FGFR) signaling. In particular, FGF19 and FGF21 function through β-Klotho regulate glucose lipid metabolism. Recent research has focused on elucidating how these two FGFs interact with FGFRs downstream this study, using hydrogen deuterium exchange coupled mass spectrometry (HDX-MS), we identified regions the protein that likely participate in ligand...
As sources of Rhizoma Paridis are facing shortages, utilising the aerial parts Paris polyphylla has emerged as a promising additional source. However, components in still need to be explored, and it is difficult distinguish P. Smith var. yunnanensis (PPY) chinensis (PPC), two varieties polyphylla.This study aimed establish comprehensive platform characterise steroid saponins from PPY PPC discriminate these varieties.A dereplication approach ultra-high-performance liquid chromatography...
Abstract Elevated serum uric acid (SUA) levels have been previously reported to play a role in multiple types of cancers. However, epidemiological studies evaluating SUA and colorectal cancer risk remain sparse. This cohort study included 444 462 participants between the ages 40 69 years from UK Biobank, followed up 2006 2010. Multivariable adjusted Cox regression models were used estimate hazard ratios (HRs). During mean follow‐up 6.6 years, 2033 855 cases colon rectal cancers,...
Abstract Background and aims Steatosis is the early pathological change in alcohol‐associated liver disease. However, its precise mechanism still unclear. The present study aimed to explore role of acetyl‐CoA synthetase 2 (ACSS2) acute alcohol‐induced lipogenesis. Methods increase ACSS2 nuclear import histone H3 acetylation were observed mice after intraperitoneally injected with g/kg ethanol or oral administration 5 also validated hepatocytes stimulated acetate. was further explored...
Introduction: The incidence of cholangiocarcinoma (CCA) has increased worldwide in recent years. Given the poor prognosis associated with current management approach CCA, new therapeutic agents are warranted to improve this patient population. Methods: In study, we extracted five cardiac glycosides (CGs) from natural plants: digoxin, lanatoside A, C, B, and gitoxin. Follow-up experiments were performed assess effect these extracts on cells compounds best efficacy selected. Lanatoside C (Lan...
The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. redU mutants did not synthesize undecylprodigiosin, while failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development S. coelicolor, although their mutation could influence these processes.