A5072233581- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gout, Hyperuricemia, Uric Acid
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Cancer Mechanisms and Therapy
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Gut microbiota and health
- Liver Diseases and Immunity
- RNA modifications and cancer
- Pregnancy and preeclampsia studies
- Inflammatory Bowel Disease
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
Lanzhou University
2020-2025
Zhejiang A & F University
2023-2025
First Hospital of Lanzhou University
2020-2024
Sun Yat-sen University
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
First Hospital of Jilin University
2023
Jilin University
2023
Jining Medical University
2022-2023
Extracellular vesicles (EVs) exert a significant influence not only on the pathogenesis of diseases but also their therapeutic interventions, contingent upon variances observed in originating cells. Mitochondria can be transported between cells via EVs to promote pathological changes. In this study, we found that derived from M1 macrophages (M1-EVs), which encapsulate inflammatory mitochondria, penetrate pancreatic beta Inflammatory mitochondria fuse with cells, resulting lipid peroxidation...
Abstract Background The global dementia prevalence is surging, necessitating research into contributing factors. We aimed to investigate the association between metabolic syndrome (MetS), its components, serum uric acid (SUA) levels, and risk. Methods Our prospective study comprised 466,788 participants without pre-existing MetS from UK Biobank. confirmed diagnoses based on ICD-10 criteria (F00-03). To evaluate risk concerning MetS, SUA we applied Cox proportional hazards models, while...
Cholangiocarcinoma (CCA) is a bile duct malignancy with dismal prognosis. This study systematically investigated the role of ribosomal protein S6 (
<title>Abstract</title> <bold>Background</bold> Mediterranean Diet (MED) is recommended for managing patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). However, the potential metabolic changes involved in this relationship remain unclear. This study aims to investigate how biomarkers mediate association between MED adherence and liver-related events (LRE) mortality MASLD.<bold>Methods</bold> We performed a prospective analysis using UK Biobank data, including...
Despite increasing evidence supporting the role of an amniotic epithelial-mesenchymal transition (EMT) in premature rupture membranes (PROMs), it remains unclear if extracellular vesicle (EV) derived from M1 macrophages play a critical triggering EMT epithelial cells (AECs). This study revealed that under inflammatory conditions, EV-miR-146a/155 could trigger EMTs and MMP-9 transcription AECs, elevating risk PROM both mice humans. Introduction EV-miR-155 led to inhibition Ehf expression...
Abstract Background Paracetamol induces hepatotoxicity and subsequent liver injury, which may increase the risk of cancer, but epidemiological evidence remains unclear. We conducted this study to evaluate association between paracetamol use cancer. Methods This prospective included 464,244 participants free cancer diagnosis from UK Biobank. Incident was identified through linkage death registries National Health Service Central Register using International Classification Diseases (ICD)-10...
Background Uric acid is the end product of purine metabolism. Previous studies have found that serum uric (SUA) levels are associated with total cancer risk. However, due to dual effect on cancer, relationship between SUA and most specific-site remains unclear. Aim To investigate associations incidence hepatobiliary-pancreatic cancer. Methods In this prospective cohort study, 444462 participants free from UK Biobank were included. The measured at baseline, was determined by contacting...
Abstract Background Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but extent which increased genetic risk can be mitigated by adhering a healthy remains unclear. We aimed investigate association combined with cancer within groups. Methods conducted prospective study 375 998 unrelated participants European ancestry genotype data free from UK biobank. generated polygenic score (PRS) using 16 single nucleotide polymorphisms based on body weight, smoking...
Abstract Elevated serum uric acid (SUA) levels have been previously reported to play a role in multiple types of cancers. However, epidemiological studies evaluating SUA and colorectal cancer risk remain sparse. This cohort study included 444 462 participants between the ages 40 69 years from UK Biobank, followed up 2006 2010. Multivariable adjusted Cox regression models were used estimate hazard ratios (HRs). During mean follow‐up 6.6 years, 2033 855 cases colon rectal cancers,...
Circular RNA (circRNA) is a type of stable non-coding that modifies macrophage inflammation by sponging micro RNAs (miRNAs), binding to RNA-binding proteins, and undergoing translation into peptides. Activated M1 phenotype macrophages secrete matrix metalloproteinases participate in softening the cervix uteri promote vaginal delivery.In this study, premature rupture membranes (PROM) mouse model was used analyze role process. Profiling circRNAs performed using competing endogenous microarray,...
Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its diagnosis still challenge. This study aimed to identify novel bile marker for CCA based on proteomics establish diagnostic model with deep learning.
Abstract Background Limited epidemiological evidence exists regarding the role of healthy eating patterns in reducing risk Crohn’s disease (CD) and ulcerative colitis (UC). This study aimed to investigate association between adherence four established subsequent CD or UC risk, further examined whether these associations are linked anti-inflammatory mechanisms. Methods We conducted a prospective cohort 197,391 participants from UK Biobank who completed at least one dietary questionnaire were...
Introduction: The incidence of cholangiocarcinoma (CCA) has increased worldwide in recent years. Given the poor prognosis associated with current management approach CCA, new therapeutic agents are warranted to improve this patient population. Methods: In study, we extracted five cardiac glycosides (CGs) from natural plants: digoxin, lanatoside A, C, B, and gitoxin. Follow-up experiments were performed assess effect these extracts on cells compounds best efficacy selected. Lanatoside C (Lan...
Introduction Pancreatic cancer (PC) is a malignancy with poor prognosis. This investigation aimed to determine the relevant genes that affect prognosis of PC and investigate their relationship immune infiltration. Methods : First, we acquired single-cell chip data from GEO database scrutinize dissimilarities in cell infiltration differential between cancerous adjacent tissues. Subsequently, combined clinical TCGA identify Employing Cox Lasso regression analyses, constructed multifactorial...
Background Limited epidemiological evidence exists concerning the impact of healthy dietary patterns on reducing risk cholelithiasis. We aimed to examine association seven established with subsequent cholelithiasis and whether this was modified by genetic risk. Methods conducted a prospective cohort study from UK Biobank, including 155,323 participants initially free cholecystectomy. Dietary were assessed using validated food frequency questionnaire (Oxford WebQ), covering Mediterranean Diet...
INTRODUCTION: Gallstone diseases affect intestinal inflammation, bile flow, and gut microbiota, which in turn may increase the risk of inflammatory bowel disease (IBD). However, epidemiological studies exploring associations between gallstone subsequent IBD have been limited. METHODS: This is a combined analysis 3 prospective cohort (Nurses' Health Study, Nurses' Study II, UK Biobank) replicated case-control study (Chinese Etiology Study). We evaluated hazard ratios (HRs)/odds (ORs) with by...
Gallbladder drainage plays a key role in the management of acute cholecystitis (AC) patients. Percutaneous transhepatic gallbladder (PTGBD) is commonly used while endoscopic naso-gallbladder (ENGBD) serves as an alternative. A single center, prospective randomized controlled trial was performed. Eligible AC patients were randomly assigned to ENGBD or PTGBD group. Randomization computer-generated list with 1:1 allocation. All received cholecystectomy 2-3 months after drainage. The primary...
Background: Recent studies have shown that bile acids are essential in irritable bowel syndrome (IBS) pathology, and cholecystectomy has direct effects on acid metabolism. However, whether increases the risk of IBS remains unclear. We aimed to investigate association between UK Biobank (UKB). Methods: This study is a prospective analysis 413,472 participants who were free IBS, inflammatory disease, cancer, or common benign digestive tract diseases. identified incidents through self-reporting...