A5101506183- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Hepatitis C virus research
- Tryptophan and brain disorders
- Dietary Effects on Health
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Heme Oxygenase-1 and Carbon Monoxide
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Medical and Biological Sciences
- HVDC Systems and Fault Protection
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
82th Hospital of Pla
2020
Shandong University
2016-2020
Shandong Provincial Hospital
2020
458th Hospital PLA
2019
General Hospital of Jinan Military Command
2016
Air Force Medical University
2013
University of Arizona
1990
Previous reports have shown that [Leu5]enkephalin or [Met5] enkephalin, endogenous delta receptor agonists, synthetic analogues of these substances, can respectively produce a positive (i.e., increase) negative decrease) modulation the antinociceptive potency mu agonists such as morphine; is believed to be result interactions between and receptors. In spite studies showing agonist potency, it unclear whether similarly modulate efficacy agonists. This question was addressed by using several...
Abstract Background Limited epidemiological evidence exists regarding the role of healthy eating patterns in reducing risk Crohn’s disease (CD) and ulcerative colitis (UC). This study aimed to investigate association between adherence four established subsequent CD or UC risk, further examined whether these associations are linked anti-inflammatory mechanisms. Methods We conducted a prospective cohort 197,391 participants from UK Biobank who completed at least one dietary questionnaire were...
Background: Gastric acid suppressants have a major impact on gut microbiome which in turn, may increase the risk of cholelithiasis, but epidemiological evidence remains unclear. We undertook this research to evaluate association between regular use proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) with cholelithiasis. Methods: Prospective cohort study included 477,293 UK residents aged 37-73 years from Biobank. participants reported PPI or H2RA use, were free cholelithiasis...
AimCarbon monoxide (CO) poisoning can cause permanent damage in tissues that are sensitive to hypoxia. We explored the feasibility and efficacy of using a hyperoxygenated solution (HOS) treat severe acute CO an animal model. MethodsMale Sprague-Dawley rats were subjected poisoning. The HOS was administered into femoral vein these through catheter (10 ml/kg). Carboxyhemoglobin (COHb) blood gases used assess early caused by S100β measured predict development late cognitive sequelae CO. Morris...
"Stress-induced hyperalgesia (SIH)" is a phenomenon that stress can lead to an increase in pain sensitivity. Epigenetic mechanisms have been known play fundamental roles and pain. Histone acetylation epigenetic feature changed numerous stress-related disease situations. However, mechanism for SIH not well known. We investigated the effect of histone on hypersensitivity using SPS (single-prolonged stress) + CFA (complete Freund's adjuvant) model. showed glucocorticoid receptor...
Intermittent hypoxia (IH) is the core pathological feature of obstructive sleep apnea syndrome (OSAS), and insulin resistance (IR) most common metabolic complication OSAS. Studies have shown that levels free fatty acids (FFAs), which are mainly released from adipocytes by lipolysis, elevated in OSAS play an important role development IR. However, whether how IH regulates adipocyte lipolysis not clear. Here, we revealed hypopnea index was positively correlated with serum FFAs FFA release In...
We aimed to establish a novel prognostic long noncoding RNA (lncRNA) signature for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) patients after hepatectomy and validate its efficacy compared with other clinical staging systems.Expression data of 374 HCC samples were retrieved from The Cancer Genome Atlas (TCGA) database. Cox regression analyses performed develop the lncRNA model. expression levels lncRNAs detected by qualitative real-time polymerase chain reaction (qRT-PCR) in...
Abstract “Stress-induced hyperalgesia (SIH)” is a phenomenon that stress can lead to an increase in pain sensitivity. Recent findings showed epigenetic mechanisms have been known play fundamental roles and pain. Histone acetylation outstanding feature changed numerous stress-related disease situations. However, mechanism for the control of SIH not well known. We investigated effect histone acetylationon hypersensitivity on SPS (single-prolonged stress) + CFA (complete Freund’s adjuvant)...
Objective To investigate the connections between neurokinin 1 (NK1) receptor-like immunoreactive (LI) neurons and -aminobutyric acid- (GABA), substance P- (SP) positive axonal terminals in Locus Coeruleus (LC) of rat. Methods Immunofluorecent histochemical double-staining combining electron microscope technique was used to observe NK1 receptor-LI GABA- or SP-positive 10 male SD rats (250-300 g). Results Under laser confocal microscopy, some these GABA-, SP-LI axon were observed...