A5041018766- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Protein Tyrosine Phosphatases
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Systemic Sclerosis and Related Diseases
- HVDC Systems and Fault Protection
- Salivary Gland Disorders and Functions
- Cancer Genomics and Diagnostics
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Pancreatic adenocarcinoma (PAAD) is a highly aggressive cancer with poor prognosis, reliable markers are urgently needed for early detection and prognosis evaluation. SAPCD2, cell cycle related gene, has been implicated in tumorigenesis proposed as potential therapeutic target cancer. However, no comprehensive study explored its expression regulation, discussed role tumor immune modulation, along therapy response pan-cancer until now. SAPCD2 was analyzed using data from The Cancer Genome...
Abstract Mesenchymal stem cells (MSCs) hold immense potential as multipotent and serve a primary source of adipocytes. The process MSC adipogenesis plays crucial role in maintaining systemic metabolic homeostasis has garnered significant attention tissue bioengineering. N6-methyladenosine (m6A), the most prevalent RNA modification, is known to regulate cell fate disease. However, precise involvement m6A readers remains unclear. In this study, we investigated impact IGF2BP3, prominent reader,...
Intermittent hypoxia (IH) is the core pathological feature of obstructive sleep apnea syndrome (OSAS), and insulin resistance (IR) most common metabolic complication OSAS. Studies have shown that levels free fatty acids (FFAs), which are mainly released from adipocytes by lipolysis, elevated in OSAS play an important role development IR. However, whether how IH regulates adipocyte lipolysis not clear. Here, we revealed hypopnea index was positively correlated with serum FFAs FFA release In...