A5079490716- Hearing, Cochlea, Tinnitus, Genetics
- Tattoo and Body Piercing Complications
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Syphilis Diagnosis and Treatment
- Ear Surgery and Otitis Media
- RNA regulation and disease
- Helicobacter pylori-related gastroenterology studies
- Streptococcal Infections and Treatments
- RNA modifications and cancer
- Electromagnetic wave absorption materials
- Sinusitis and nasal conditions
- Plant Molecular Biology Research
- Gut microbiota and health
- Nasal Surgery and Airway Studies
- Wound Healing and Treatments
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
- RNA Research and Splicing
- Skin and Cellular Biology Research
- Mechanisms of cancer metastasis
Sun Yat-sen University
2018-2024
Sun Yat-sen Memorial Hospital
2018-2024
Cisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug practice and known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role cisplatin's inner ear toxicity. Hesperidin flavanone glycoside extracted from citrus fruits has anti-inflammatory antioxidant Nonetheless, specific pharmacological actions hesperidin alleviating cisplatin-induced ototoxicity remain elusive. The...
Cisplatin-induced ototoxicity is one of the common side effects during its treatment and there are no effective measures to prevent it. Our study aimed investigate effect ACSL4-catalyzed lipid peroxidation on cisplatin-induced hearing loss possible protective mechanisms. We used a variety cisplatin models, including HEI-OC1 cell line, cochlear explants, ET4 GFP+ zebrafish. After measuring experimental concentrations by CCK8 assay immunofluorescence, respectively, we examined levels MDA...
The function of astrocytes in response to gut microbiota-derived signals has an important role the pathophysiological processes central nervous system (CNS) diseases. However, specific effects metabolites on astrocyte activation have not been elucidated yet. Experimental autoimmune encephalomyelitis (EAE) was induced female C57BL/6 mice as a classical MS model. alterations microbiota and levels short-chain fatty acids (SCFAs) were assessed after EAE induction. We observed that exhibit low...
Abstract Mesenchymal stem cells (MSCs) hold immense potential as multipotent and serve a primary source of adipocytes. The process MSC adipogenesis plays crucial role in maintaining systemic metabolic homeostasis has garnered significant attention tissue bioengineering. N6-methyladenosine (m6A), the most prevalent RNA modification, is known to regulate cell fate disease. However, precise involvement m6A readers remains unclear. In this study, we investigated impact IGF2BP3, prominent reader,...
Objectives/Hypothesis To investigate the simultaneous application of cartilage tympanoplasty combined with eustachian tube (ET) balloon dilatation in treatment adhesive otitis media (AdOM). Study Design Multicenter, prospective, double‐blind, randomized, controlled clinical trial. Methods Patients AdOM were randomly divided into four groups: control group (conservative treatment), ET (ETBD) group, (CT) and (ETBD+CT) group. followed up at 3 months, 6 1 year, 2 years after treatment, receiving...
Aims: Radiation-induced sensorineural hearing loss (RISNHL) is one of the major side effects radiotherapy for head and neck cancers. At present, no effective clinical treatment or prevention available RISNHL. This study thus aimed to investigate cochlear pathology so that underlying mechanisms RISNHL may be elucidated, consequently paving way potential protective strategies developed.
Chronic otitis media (COM) is an inflammatory disease that commonly presents with otorrhea and hearing loss. Bacteria-induced inflammation can cause inner ear damage, leading to sensorineural loss (SNHL). This study aimed compare the prevalence severity of SNHL in patients gram-negative versus gram-positive cultures examine associations between concentrations circulating monocytes neutrophils bacteria species SNHL.
The authors declare that they have no known competing financial interests or personal relationships could appeared to influence the work reported in this paper. conflicts of interest. peer review history for article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/coa.14224. confirm data supporting findings study are within article.
Acquired cholesteatoma is characterized by hyper-keratinized squamous epithelium and bone destruction. However, direct evidence for epidermis promoting destruction lacking.To determine whether higher degree of keratinization correlated with severe further offer keratinocyte-inducing osteoclastogenesis.Histological changes clinical relevance were analyzed in human-acquired cholesteatoma. Animal models established implanting autologous different degrees keratinization. The severity resorption...