A5108738471- Cancer-related molecular mechanisms research
- Wheat and Barley Genetics and Pathology
- Bone fractures and treatments
- Reconstructive Surgery and Microvascular Techniques
- Circular RNAs in diseases
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Plant Stress Responses and Tolerance
- Plant Disease Resistance and Genetics
- Crop Yield and Soil Fertility
- Surgical Sutures and Adhesives
- Biofuel production and bioconversion
- Plant-Microbe Interactions and Immunity
- Plant Molecular Biology Research
- Hip and Femur Fractures
- Plant Genetic and Mutation Studies
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- COVID-19 Clinical Research Studies
- Myofascial pain diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
Anhui Medical University
2024
Sun Yat-sen University
2024
Sun Yat-sen Memorial Hospital
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Second Hospital of Anhui Medical University
2024
Jinan Central Hospital
2024
Shandong First Medical University
2024
Virginia Tech
2022-2024
Youjiang Medical College for Nationalities
2024
Wuhan Puai Hospital
2017-2024
Cultivating new crop cultivars with multiple abiotic stress tolerances is important for production. The abscisic acid-stress-ripening (ASR) protein has been shown to confer tolerance in plants. However, the mechanisms of ASR function under condition remain largely unclear. In this study, we characterized all family members common wheat and constitutively overexpressed TaASR1-D a commercial hexaploid cultivar Zhengmai 9023. transgenic plants exhibited increased stresses grain yields salt...
Cisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug practice and known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role cisplatin's inner ear toxicity. Hesperidin flavanone glycoside extracted from citrus fruits has anti-inflammatory antioxidant Nonetheless, specific pharmacological actions hesperidin alleviating cisplatin-induced ototoxicity remain elusive. The...
The trihelix gene family is a plant-specific transcription factor that plays important roles in plant growth, development, and responses to abiotic stresses. However, date, no systemic characterization of the genes has yet been conducted wheat its close relatives. We identified total 94 wheat, as well 22 Triticum urartu, 29 Aegilops tauschii, 31 Brachypodium distachyon. analyzed chromosomal locations orthology relations genes, was found be located on chromosome 7A, 7B, or 7D thereby...
Plant protein phosphatase 2Cs (PP2Cs) play crucial roles in phytohormone signaling, developmental processes, and both biotic abiotic stress responses. However, little research has been conducted on the PP2C gene family hexaploid wheat (Triticum aestivum L.), which is an important cereal crop. In this study, a genome-wide investigation of TaPP2C was performed. A total 257 homoeologs 95 genes were identified, 80% had all three across A, B, D subgenomes. Domain analysis indicated that harbored...
WD40 domains are abundant in eukaryotes, and they essential subunits of large multiprotein complexes, which serve as scaffolds. proteins participate various cellular processes, such histone modification, transcription regulation, signal transduction. regarded crucial regulators plant development processes. However, the systematic identification analysis have yet to be reported wheat. In this study, a total 743 were identified wheat, grouped into 5 clusters 11 subfamilies. Their gene...
Cadmium (Cd) accumulation in rice grain is of health concern. Identifying genes involved Cd and performing molecular breeding may reduce it. In this study, knockout OsNRAMP2, a member the NRAMP family, reduced concentrations by more than 38%, overexpressing OsNRAMP2 increased 50%. Physiological experiments showed that facilitated translocation from root to shoot positively regulating efflux vacuoles. At filling stage, was highly expressed all tissues except for husk, suggesting its role...
Wheat, a major worldwide staple food crop, is relatively sensitive to changing environment, including high temperature. The comprehensive mechanism of heat stress response at the molecular level and exploitation candidate tolerant genes are far from enough. Using transcriptome data, we analyzed gene expression profiles wheat under stress. A total 1705 17 commonly differential expressed (DEGs) were identified in grain flag leaf, respectively, through analysis. Gene Ontology (GO) pathway...
Abstract Background The accurate identification of the functional elements in bovine genome is a fundamental requirement for high-quality analysis data informing both biology and genomic selection. Functional annotation was performed to identify more complete catalog transcript isoforms across tissues. Results A total 160,820 unique transcripts (50% protein coding) representing 34,882 genes (60% were identified Among them, 118,563 (73% total) structurally validated by independent datasets...
Abstract Background As the sixth most common cancer worldwide, head and neck squamous cell carcinoma (HNSCC) develops visceral metastases during advanced stage of disease exhibits a low five-year survival rate. The importance tumor microenvironment (TME) in initiation metastasis is widely recognized. In addition, accumulating evidence indicates that long non-coding RNA (lncRNA) involved crosstalk between TME cells. However, lncRNA-associated regulators modulating HNSCC progression remain...
BACKGROUND Salidroside, a natural dietary isothiocyanate, has been widely studied for its multiple effects, including promoting proliferation, anti-inflammation, and anti-apoptosis. In the present study, these effects of Salidroside were explored to assess whether it could prevent osteoarthritis (OA) in vitro. MATERIAL AND METHODS The cytotoxic proliferating on chondrocytes detected by use Cell Counting Kit 8 assay. expression levels proteins Western blot. cell apoptosis level was assessed...
Abstract Background Atherosclerosis is the leading cause of cardiovascular disease with a high mortality worldwide. Understanding atherosclerosis pathogenesis and identification efficient diagnostic signatures remain major problems modern medicine. This study aims to screen potential genes for atherosclerosis. Methods We downloaded gene chip data 135 peripheral blood samples, including 57 samples 78 healthy subjects from GEO database (Accession Number: GSE20129). The weighted co-expression...
Preeclampsia (PE) is a complication of pregnancy, and leading cause maternal mortality morbidity worldwide. Recently, the dysregulation long non‑coding RNAs (lncRNAs) has been reported to contribute pathogenesis progression PE. This study aimed examine alterations in lncRNA family with sequence similarity 99 member A (FAM99A) PE its effects on trophoblasts. The results reverse transcription‑quantitative PCR indicated that expression levels FAM99A were downregulated placental tissues from...
Pulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are few effective drugs approved for pulmonary treatment. This study aimed to evaluate the effect of praziquantel (PZQ) on bleomycin (BLM)-induced fibrosis.
Aim Occlusion dysfunction (OD) is increasingly linked to Alzheimer’s disease (AD). This study aimed elucidate the causal relationship between OD and AD using Mendelian randomization (MR) analysis. Materials methods Genome-wide association (GWAS) meta-analysis data obtained from FinnGen, IEU Open GWAS, UK Biobank (UKBB) was represented as instrumental variables. We validated periodontal (PD), loose teeth (PD & occlusion dysfunction), dentures restoration (occlusion recovery), AD....
The present study aimed to validate the association between core cuproptosis genes (CRGs) and Alzheimer's disease (AD) from both bioinformatics experimental perspectives also develop a risk prediction model. To this end, 78 human‑derived temporal back samples were analyzed GSE109887, biological functions of resulting CRGs explored by cluster analysis, weighted gene co‑expression network analysis similar methods identify best machine Moreover, an external dataset GSE33000 nomogram used mRNA...
Semen Ziziphi Spinosae (SZS) and Fructus Gardeniae (FG) are two herbs commonly used in traditional Chinese medicine. Previous studies have suggested that as well able to regulate the function of central nervous system. However, their effect on learning memory has yet be elucidated. In this study, we examined SZS FG mice using methods step-through -down passive avoidance tasks Morris water maze tasks. The results showed extracts certain effects improving performance memory-impaired mouse...
Objective: The reconstruction of complex soft tissue defects with exposure bones and tendons represents an increasing challenge in wound care, especially large extremity wounds. aim this study was to detect the clinical efficacy combined use negative pressure therapy (NPWT), artificial dermis (ADM), platelet-rich plasma (PRP) split-thickness skin grafting (STSG) traumatic defects. Method: In study, eight cases were treated therapies for repairing wounds results reviewed retrospectively....