A5100769310- Sinusitis and nasal conditions
- Parasitic infections in humans and animals
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Congenital Anomalies and Fetal Surgery
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Nasal Surgery and Airway Studies
- Head and Neck Surgical Oncology
- Renal Transplantation Outcomes and Treatments
- Allergic Rhinitis and Sensitization
- Acne and Rosacea Treatments and Effects
- Pediatric health and respiratory diseases
- Herpesvirus Infections and Treatments
- Oral Health Pathology and Treatment
- Otitis Media and Relapsing Polychondritis
- Cancer Cells and Metastasis
- Psoriasis: Treatment and Pathogenesis
- Amoebic Infections and Treatments
- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Pharmacy and Medical Practices
- Chemokine receptors and signaling
- Mast cells and histamine
- Tryptophan and brain disorders
Second Affiliated Hospital of Xi'an Jiaotong University
2018-2025
Xi'an Jiaotong University
2024
Xiangya Hospital Central South University
2014-2020
Central South University
2008-2020
Huazhong University of Science and Technology
2019
Third Xiangya Hospital
2008-2015
Hunan University of Traditional Chinese Medicine
2015
PharmacoGenetics (China)
2015
Beijing Chao-Yang Hospital
2015
Capital Medical University
2015
A cross-sectional survey of healthcare professionals from 19 hospitals in six cities Heilongjiang Province, China was conducted. This study had two objectives: (1) to examine the factors influencing workers' opinions strategies prevent workplace violence, using social support theory, and (2) encourage organisations larger society offer greater workers. The respondents exposed violence expected receive organisational support. Those psychological a strong opinion need for target training...
Endoplasmic reticulum stress (ERS) has recently been proposed as a core factor in the pathogenesis and aggravation of rosacea. The roles ERS-related genes rosacea are largely unknown were investigated this study. Rosacea microarray datasets downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed patients vs. controls screened using Limma package, LASSO regression was used to screen for characteristic genes. infiltrating fraction evaluated ssGSEA. Clinical samples,...
The management of papulopustular rosacea presents a significant clinical challenge. Anti-inflammatory and vasoconstrictive treatments are ineffective in the rapid amelioration dryness, burning, itching caused by skin barrier damage patients with rosacea. To assess efficacy safety topical application compound heparin sodium allantoin gel to treat Eighty-two participated this randomized, prospective, single-center, controlled trial. Clinician Erythema Assessment score, Investigator Global...
AbstractAirborne particulate matter (PM) exposure is a major environmental health concern and linked to metabolic disorders, such as cardiovascular diseases (CVD) diabetes, which are on the rise in Kingdom of Saudi Arabia. This study investigated changes mouse lung gene expression produced by administration PM10 collected from Jeddah, FVB/N mice were exposed 100 μg or water aspiration euthanized 24 h later. The bronchoalveolar lavage fluid (BALF) was analyzed for neutrophil concentration...
PER3, a circadian clock gene, plays an important role in colorectal cancer, but its action and underlying mechanism cancer stem-like cells (CSCs) remain unclear. In this study, the CSCs were enriched HCT-116 sphere-forming cells, expressing lower levels of stem cell markers CD133, CD44, LGR5, SOX2 compared with cells. A drug-resistant strain from was established. Western blot qRT-PCR analysis showed that PER3 downregulated HCT-116. Overexpression could strengthen 5-FU-induced inhibitory...
This study applied the non-parametric four-stage data envelopment analysis method (Four-Stage DEA) to measure relative efficiencies of Chinese public hospitals from 2010 2016, and determine how were affected by eight factors. A sample (n = 84) was selected Chongqing, China, including general traditional medicine graded level 2 or above. The Four-Stage-DEA chosen since it enables control impact environment factors on efficiency evaluation results. Data number staff, government financial...
Rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor used to lower blood low-density lipoprotein cholesterol, is substrate of the membrane ABCG2 exporter. variants have been shown alter rosuvastatin disposition. The objective this study determine impact 34/421 compound haplotypes on pharmacokinetics in healthy Chinese volunteer subjects. Eight hundred males were genotyped by polymerase chain reaction-pyrosequencing for 34G>A, 421C>A, SLCO1B1 521T>C, and CYP2C9*3...
The prevalence of anxiety and depression is significantly higher in individuals with psoriasis than the general population. Clinical data also show that anti-anxiety antidepression drugs can reduce skin lesions patients psoriasis, but actual mechanism still poorly understood.To investigate whether brain-derived neurotrophic factor (BDNF) tropomyosin receptor kinase B (TrKB) signalling plays a role underlying behaviours.Expression BDNF K5.Stat3C mouse, an animal model were investigated by...
Abstract Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a heterogeneous disorder that can be classified into either eosinophilic or noneosinophilic endotypes. However, the immunological mechanisms of each remain unclear. The purpose present study was to compare and analyze inflammatory signatures CRSwNP (ECRSwNP) (NECRSwNP). Cytokine antibody array used identify mediators were differentially expressed among ECRSwNP, NECRSwNP, control groups. Then, bioinformatics approaches...
Papulopustular rosacea (PPR) is a chronic inflammatory disease with significant impact on facial aesthetics. An impaired skin barrier an important factor in the development and exacerbation of PPR. Tranexamic acid (TXA) has immune regulatory anti-inflammatory effects, inhibits angiogenesis endothelial hyperplasia, promotes repair.
Betel quid chewing has been a major risk factor for oral cancer (OC) in southern China. This study aimed to analyze the scientific publications on relationship between betel and OC construct model quantitatively qualitatively evaluate pertinent from 1998 2017.The 2017 were retrieved Web of Science Core Collection database. Microsoft Excel, Thomson Data Analyzer, VOSviewer, CiteSpace software used publication outcomes, journals, countries/regions, institutions, authors, research areas,...
Aortic allotransplantation is a reliable procedure to study the evolvement of chronic rejection in mice. The progressive nature this process mice characterized by diffuse and concentric myointimal proliferation which inevitably associated with variable degrees luminal constriction. These vascular changes are comparable those that witnessed organ allografts undergoing humans, underscoring its utility as model choice for development lesion. Whilst improved surgical technique has resulted...
To compare protein expression in nasal polyps, chronic sinusitis, and normal mucosa tissues using proteomic technology.Cross-sectional survey.Proteins extracted from the three kinds of (seven samples per group) were separated by immobilized pH4-7 gradient two-dimensional gel electrophoresis (2-DE). PDQuest software was used to analyze 2-DE images, differentially expressed spots identified with use both MALDI-TOF-MS ESI-Q-TOF-MS. Of proteins, Cu/ZnSOD PLUNC validated immunohistochemical...
Wild-type p53-induced phosphatase (WIP1) is overexpressed and functionally altered in multiple human malignancies. The present study investigated its abnormal expression dysfunctions nasopharyngeal carcinoma (NPC) vitro. Here, analysis of WIP1 mRNA protein NPC tissues revealed that both messenger RNA (mRNA) were elevated correlated with clinical stage metastasis patients. In vitro experiments further showed inhibition led to a decrease the proliferative ability CNE-2 5-8F cells accompanied...
Glycinin and β-conglycinin are major soybean allergens involved in food hypersensitivity. However, the mechanism of immune responses induced by glycinin has not been fully understood. Balb/c mice were oral sensitised with different doses (0.1, 1.0 10 mg/day) for five weeks. Allergen-specific immunoglobulin (Ig), serum histamine T-cell tested to assess allergenic activity β-conglycinin. Mice 0.1 or mg/day high levels specific IgE, IgG1 compared treated saline. Furthermore, proliferation...
Abstract Our study presents the genetic landscape betel quid chewing‐associated tongue carcinomas (BQ‐TCs). We compared and mutational signatures of 15 BQ‐TCs, five nonbetel (nBQ‐TCs), 82 in general population from TCGA (TCGA‐TCs) project. The highlights this research mainly include: (a) BQ‐TC was characterized with frequent mutations RASA1 gene CpG islands throughout genome. (b) had a distinct signature that nBQ‐TC population, associated islands. (c) indicates (BQ) chewing classifies group...
ABSTRACT: Backgr ound : Vaccination is an important method for the prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. There currently a lack real-world clinical data regarding safety and efficacy disease 2019 (COVID- 19) vaccines with respect to plaque psoriasis treatment involving tumor necrosis factor (TNF)-α interleukin (IL)- 17A inhibitors. Method s: We longitudinally analyzed 152 patients psoriasis, 86 whom received two doses inactivated COVID- 19...