A5100752315- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Endoplasmic Reticulum Stress and Disease
- Generative Adversarial Networks and Image Synthesis
- Digital Media Forensic Detection
- Urticaria and Related Conditions
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Multimodal Machine Learning Applications
- melanin and skin pigmentation
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Advanced Steganography and Watermarking Techniques
- Spondyloarthritis Studies and Treatments
- ATP Synthase and ATPases Research
- Antimicrobial Peptides and Activities
- Hepatitis B Virus Studies
- Inflammatory mediators and NSAID effects
- Vitamin C and Antioxidants Research
- Underground infrastructure and sustainability
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced Sensor Technologies Research
Shandong Sport University
2025
Shanghai University of Traditional Chinese Medicine
2025
Institute of Wetland Research
2024
Chinese Academy of Forestry
2024
Tongji University
2013-2024
Shanghai Skin Disease Hospital
2013-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
South China University of Technology
2023
Weifang Medical University
2023
Data hiding such as steganography and invisible watermarking has important applications in copyright protection, privacy-preserved communication content provenance. Existing works often fall short either preserving image quality, or robustness against perturbations are too complex to train. We propose RoSteALS, a practical technique leveraging frozen pretrained autoencoders free the payload embedding from learning distribution of cover images. RoSteALS lightweight secret encoder just 300k...
Purpose: Inflammasome activation and IL-1β production have been proposed to an important role in age-related macular degeneration (AMD). Growing evidence is emerging for involvement of interleukin-17A (IL-17A) AMD pathogenesis. We investigated the effects IL-17A on inflammasome primary human RPE cells. Methods: Primary cells were isolated cultured following experiments. Expression patterns IL-17 receptor A (IL-17RA), C (IL-17RC), ACT1 analyzed by RT-PCR, flow cytometry, immunofluorescence....
Background Prehypertension is the preclinical stage of hypertension, which more likely to develop into hypertension than normal blood pressure. Although body may experience pathological changes at this stage, there are often no symptoms. Chinese medicine constitution theory widely used assess an individual’s health and disease status, provides a new method for prevention. The phlegm-dampness (PDC) main in prehypertension. Dysbiosis intestinal flora considered be related development...
Interleukin (IL)-1β is now emerging as a critical cytokine in the pathogenesis of T helper type 17 (Th17)-mediated skin diseases, including psoriasis. Psoriatic keratinocytes are major source IL-1β; however, mechanisms triggering IL-1β processing remain unknown. Recently, an acute-phase protein serum amyloid A (SAA) has been identified danger signal that triggers inflammasome activation and secretion. In this study, we detected increased SAA mRNA expression psoriatic epidermis. cultured...
Cadmium (Cd) accumulation in rice grain is of health concern. Identifying genes involved Cd and performing molecular breeding may reduce it. In this study, knockout OsNRAMP2, a member the NRAMP family, reduced concentrations by more than 38%, overexpressing OsNRAMP2 increased 50%. Physiological experiments showed that facilitated translocation from root to shoot positively regulating efflux vacuoles. At filling stage, was highly expressed all tissues except for husk, suggesting its role...
Abstract Objectives Serum amyloid A ( SAA ), an acute phase protein, is highly expressed in psoriatic lesions but its function not fully understood. The aim of this study was to explore role activation keratinocytes. Materials and methods Real‐time PCR immunofluorescence were performed examine expression imiquimod IMQ )‐induced psoriasis‐like mice. In vivo examined by treating mice with neutralising antibody. Cell viability monitored using the CCK ‐8 assay. determine genes associated...
Abstract Generalized pustular psoriasis is an immune‐mediated dermatologic condition characterized by widespread, sterile, subcorneal pustules. However, limited information exists regarding the clinical course of generalized psoriasis. This study aimed to examine precipitating factors, manifestations, laboratory data, relapse patterns, and prognosis at our hospital improve diagnosis treatment. A retrospective analysis was conducted for in department from 2014 2019. In total, 110 patients...
Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening, neutrophilic, autoinflammatory skin disease characterised by recurrent flares of generalised sterile pustules and associated systemic features. Inconsistent diagnostic criteria lack approved therapies pose serious challenges to GPP management. Our objectives were discuss the encountered in care patients with identify healthcare provider (HCP) educational needs clinical practice gaps management.On 24 July 2020, 13...
Psoriasis is an immune-related chronic skin disease, and interleukin-22 (IL-22) involved in psoriasis pathogenesis through promoting proliferation migration abilities of keratinocytes. Here, we analysed the role circular RNA (circRNA) RAB3B, member RAS oncogene family (circRAB3B) regulating phenotypes IL-22-induced HaCaT cells.RT-qPCR was implemented to assess abundance. Western blot assay adopted protein Cell capacity examined by cell counting kit-8 (CCK8) 5-ethynyl-2'-deoxyuridine (Edu)...
Data pertaining to biologic agents used for treating psoriasis in real-world settings are lacking at present. To compare drug survival 52 weeks a range of biologics treat under conditions.This was retrospective, single-center, observational study cohort patients diagnosed with plaque treated using ixekizumab, secukinumab, guselkumab, or adalimumab between January 2020 and December 2021. Baseline demographic characteristics, duration psoriasis, prior biological treatments all were recorded....
Introduction Tobacco smoking is associated with the onset and severity of psoriasis, understanding prevalence tobacco among patients psoriasis critical due to its high physical mental influence heavy disease burden. However, evidence on association between still limited in China. Objectives The objective this study was examine explore diseases psoriasis. Methods A total 4,529 200 selected hospitals were recruited China January 2020 September 2021. Detailed information covering demographic...
Abstract: As cutaneous pigment‐producing cells, melanocytes can become targets of primary and secondary immune response as be seen in diseases like vitiligo Vogt–Koyanagi–Harada (VKH) syndrome. Viral infections have previously been implicated a possible precipitating factor the destruction these disorders. During viral replication, double‐stranded RNA (dsRNA) is produced an intermediate metabolite, which induces antiviral inflammatory responses through Toll‐like receptor 3 (TLR3) cells...
Psoriasis is characterized by a T‐helper (Th)1/Th17 immune response, and an increase in IgE levels prototypical marker of Th2 immunity. The aim this retrospective case–control study was to analyse serum total generalized pustular psoriasis (GPP), rare severe variant psoriasis. patients with GPP vulgaris (PV) were compared those healthy controls. also the C‐reactive protein (CRP), indicator systemic inflammation. percentage who had increased significantly higher than that PV mean group....
The burden of hepatitis B virus (HBV) infection in China is high. safety and efficacy secukinumab psoriasis patients with HBV have not been fully elucidated. To investigate the China. In this retrospective study, 20 were identified, all whom had treated for ≥24 weeks Four chronic inactive infection, two occult other 14 resolved infection. HBV-DNA load markers measured at baseline Week 24 showed no viral reactivation. Nineteen normal levels liver enzymes after therapy. However, one patient...
Incorporating human feedback has been shown to be crucial align text generated by large language models preferences. We hypothesize that state-of-the-art instructional image editing models, where outputs are based on an input and instruction, could similarly benefit from feedback, as their may not adhere the correct instructions preferences of users. In this paper, we present a novel framework harness for visual (HIVE). Specifically, collect edited images learn reward function capture...
Abstract Background Patient global assessment (PtGA) has been recommended as one of the core domains in psoriasis clinical trials. Among multiple versions PtGA, single-question, 11-point PtGA numeric rating scale (NRS) remains to be validated patients with plaque psoriasis. Objectives To evaluate psychometric characteristics an NRS for disease severity moderate-to-severe Methods Data were analysed from 759 Shanghai Psoriasis Effectiveness Evaluation CoHort (SPEECH), a prospective,...
Text-to-image (T2I) models based on diffusion processes have achieved remarkable success in controllable image generation using user-provided captions. However, the tight coupling between current text encoder and decoder T2I makes it challenging to replace or upgrade. Such changes often require massive fine-tuning even training from scratch with prohibitive expense. To address this problem, we propose GlueGen, which applies a newly proposed GlueNet model align features single-modal...
In modern drug discovery, 2-D similarity searching is widely employed as a cost-effective way to screen large compound collections and select subsets of molecules that may have interesting biological activity prior experimental screening. Nowadays, there growing interest in applying the existing methods combinatorial chemistry libraries search for novel hits or evolve lead series. A dilemma thus arises when many identical substructures recur library products they be considered repeatedly...
Abstract Skin injury can trigger formation of new lesions in psoriasis (Koebner phenomenon). The mechanisms through which exacerbates are unclear. During wound repair, epidermal keratinocytes activated and produce abundant IL ‐36γ, further promoting the skin inflammation. ‐17A is cornerstone cytokine pathogenesis psoriasis. We sought to investigate effects on injury‐induced keratinocyte activation ‐36γ production. Here, we demonstrated that ds RNA released from necrotic induced expression...
// Li Tang 1 , Xue-Mei Yi Jia Chen 2 Fu-Juan Wei Lou Yun-Lu Gao Jing Zhou Li-Na Su Xin Xu Jia-Qing Lu Jun Ma Ning Yu Yang-Feng Ding Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, P. R. China Pathology, Correspondence to: Yang-Feng, Ding, e-mail: dingyangfeng@hotmail.com Keywords: melanoma, invasion and metastasis, ubiquitin ligase, UBE3C Received: July 24, 2015 Accepted: January 13, 2016 Published: February 15, ABSTRACT Melanoma is the most aggressive type skin cancer,...
Generalized pustular psoriasis (GPP), the most grievous variant of psoriasis, is featured by dysregulated systemic inflammatory response. The cellular and molecular basis GPP poorly understood. Blood monocytes are key players host defense producers cytokines including IL-1β. How immune response affected metabolic internal environment in remains unclear. Here, we performed a metabolomic functional investigation serum monocytes. We demonstrated significant increase IL-1β production from In...