A5043098861- Management of metastatic bone disease
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Bone Tumor Diagnosis and Treatments
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Vascular Malformations and Hemangiomas
- Neurofibromatosis and Schwannoma Cases
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Lung Cancer Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Dermatological and Skeletal Disorders
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Medical Imaging and Analysis
- Meningioma and schwannoma management
- Hypertrophic osteoarthropathy and related conditions
- Spine and Intervertebral Disc Pathology
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
First Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Zhengzhou University
2024
Qingdao Municipal Center for Disease Control and Prevention
2024
Soochow University
2024
Tsinghua University
2023
Nankai University
2022
Wuhan University
2010-2021
Renmin Hospital of Wuhan University
2012-2021
Studies investigating the relationship between maternal passive smoking and risk of preterm birth have reached inconsistent conclusions. A cohort study that included 10,095 nonsmoking women who delivered a singleton live was carried out in Lanzhou, China, 2010 2012. Exposure to during pregnancy associated with an increased very (<32 completed weeks gestation; odds ratio = 1.98, 95% confidence interval: 1.41, 2.76) but not moderate (32–36 0.98, 0.81, 1.19). Risk duration exposure (P for trend...
Genetically encoded photoswitches have enabled spatial and temporal control of cellular events to achieve tailored functions in living cells, but their applications probe the structure-function relations signaling proteins are still underexplored. We illustrate herein incorporation various blue light-responsive photoreceptors into modular domains stromal interaction molecule 1 (STIM1) manipulate protein activity faithfully recapitulate STIM1-mediated events. Capitalizing on these optogenetic...
Background: Early detection of infected patients is one the most important steps to mitigate spreading 2019 novel coronavirus (2019-nCoV). Here, we report a set atypical 2019-nCoV pneumonia cases with gastrointestinal symptoms onset but without fever or other respiratory symptoms.Methods: We retrospectively reviewed data admitted only digestive and no on from January 17-24, in Renmin Hospital Wuhan University. The patients' history, clinical features, physical findings, complete blood count,...
Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic immunomodulation. Mechanistically, ASA upregulates the telomerase reverse transcriptase (TERT)/Wnt/β-catenin cascade, leading improvement of regeneration, also TERT/FASL...
Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population, possessing multipotent differentiation capacity and immunomodulatory properties. However, the mechanism by which SHED treat immune diseases is not fully understood. Here we show that systemic transplantation of via tail vein ameliorates ovariectomy (OVX)-induced osteopenia reducing T-helper 1 (Th1) 17 (Th17) numbers in recipient OVX mice. Mechanistically, induces activated T-cell apoptosis...
Background: An outbreak and worldwide spread of COVID-19 was derived from Wuhan, China where over half the confirmed cases were reported. Protection for special populations at high infection risk such as patients with inflammatory bowel diseases (IBD) is extremely urgent challenging. Methods: We kept alerts since first reported case started to send educational instructional took measures 318 registered IBD (204 UC 114 CD) 20 days earlier shutdown Wuhan. The patients' risks, responses our...
This study aimed, through bioinformatics analysis, to identify the potential diagnostic markers of osteoarthritis, and analyze role immune infiltration in synovial tissue.The gene expression profiles were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) identified by R software. Functional enrichment analyses performed protein-protein interaction networks (PPI) constructed. Then hub screened. Biomarkers with high value for diagnosis early...
Denosumab is approved for treating hypercalcemia of malignancy, but data on its efficacy related to primary hyperparathyroidism (PHPT) are limited. To compare the and safety denosumab with zoledronic acid in PHPT-related hypercalcemia. We retrospectively collected from 29 PHPT patients moderate/severe (corrected serum calcium [CSC] ≥ 3.0 mmol/L) treated (60 or 120 mg; Dmab group) CSC-matched (4 ZA group). The outcome was change CSC (ΔCa), while secondary outcomes included response...
Interleukin (IL)-1β is now emerging as a critical cytokine in the pathogenesis of T helper type 17 (Th17)-mediated skin diseases, including psoriasis. Psoriatic keratinocytes are major source IL-1β; however, mechanisms triggering IL-1β processing remain unknown. Recently, an acute-phase protein serum amyloid A (SAA) has been identified danger signal that triggers inflammasome activation and secretion. In this study, we detected increased SAA mRNA expression psoriatic epidermis. cultured...
This study aimed to design a weighted co-expression network and breast cancer (BC) prognosis evaluation system using specific whole-genome expression profile combined with epithelial-mesenchymal transition (EMT)-related genes; thus, providing the basis reference for assessing risk of spreading metastatic (MBC) bone. Four gene datasets large number samples from GEO were downloaded dbEMT database screen out EMT differentially expressed genes (DEGs). Using GSE20685 dataset as training set, we...
Alveolar bone loss is one of the prominent pathologic and clinical features periodontitis. Recently, direct effect follicle-stimulating hormone (FSH) on resorption has been demonstrated. However, FSH alveolar remains unknown. This study tested hypothesis that would exacerbate periodontitis-related loss. Experimental periodontitis was induced in ovariectomized rats, rats were treated with extrinsic or its inhibitor, leuprorelin. After mandibles collected, we performed morphological...
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes (C-DIMs) activate the orphan receptors peroxisome proliferator-activated receptor gamma (PPARgamma) and Nur77 induce receptor-dependent -independent apoptotic pathways in colon other cancer cells. Structure-activity studies show that p-bromo (DIM-C-pPhBr) p-fluoro (DIM-C-pPhF) analogs, which exhibit minimal activation of PPARgamma, expression CCAAT/enhancer-binding protein homologous (CHOP/GADD153) Moreover, among a series bromo fluoro...
A large enhancement of anomalous Hall resistivity was obtained in the perpendicular [Co/Pt]3 multilayers sandwiched by MgO/CoO hybrid bilayers. For example, saturation (ρxy) is greatly increased, which 250% and 67% larger than that pure MgO layers, respectively. Meanwhile, magnetic anisotropy with bilayers enhanced. The ρxy originates from modified metal/oxide interfacial structures, together improved crystallization core multilayers, due to insertion
Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. IL-17 critical in inflammation, but role liver fibrosis has not yet been elucidated. In this study, we investigate on bile duct ligation-induced injury and C57BL/6 mice. Animals were sacrificed at designated times, serum tissues collected for analysis function IL-6, IL-1β, tumour necrosis factor-alpha (TNF-α) transforming growth factor-β (TGF-β) levels. blockade with anti-IL-17A mAb significantly...
The aims of this study were: (i) to determine whether the severity post-hemiplegic shoulder subluxation in stroke patients correlates with soft-tissue injury; and (ii) measurement cut-off points that are indications for further ultrasound examination injuries these patients.Cross-sectional study.A total 39 subluxation.Shoulder was evaluated by physical examination, radiography ultrasound. Soft-tissue were assessed Subluxation parameters entered into stepwise logistic regression analyses...
Advanced breast cancer commonly metastasises to bone; however, the molecular mechanisms underlying affinity for cells bone remains unclear. Thus, we developed nomograms based on a competing endogenous RNA (ceRNA) network and analysed tumour-infiltrating immune elucidate pathways that may predict prognosis in patients with cancer.We obtained expression profile of 1091 primary samples included The Cancer Genome Atlas database, 58 which were from metastasis. We differential patterns between...
To explore the role of NALP3 inflammasome [NALP3, its effector molecule apoptosis associated speck-like protein (ASC), caspase-1, interleukin (IL)-1β and IL-18] in development periapical lesions rats.Periapical were developed within 21 days after mandibular first molar pulp exposure Sprague-Dawley rats. The animals randomly sacrificed at 0, 1, 3, 7, 10, 14 pulpal exposure. bilateral mandibles extracted for histological processing, then they haematoxylin-eosin (HE) stained to examine...
Lung adenocarcinoma (LUAD) is one of the most lethal malignancies and currently lacking in effective biomarkers to assist diagnosis therapy. The aim this study investigate hub genes develop a risk signature for predicting prognosis LUAD patients.RNA-sequencing data relevant clinical were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was performed identify associated with mRNA expression-based stemness...