A5101428881- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Pediatric Hepatobiliary Diseases and Treatments
- Peroxisome Proliferator-Activated Receptors
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Heat shock proteins research
- Gastrointestinal motility and disorders
- Phagocytosis and Immune Regulation
- Birth, Development, and Health
Wuhan University
2016-2025
Renmin Hospital of Wuhan University
2016-2025
Xinjiang Production and Construction Corps
2025
Shenyang Fifth People Hospital
2024
Paraza Pharma (Canada)
2020-2024
Hebei University of Engineering
2023-2024
Wenzhou Medical University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
National Clinical Research
2024
Northwest A&F University
2023-2024
Non-invasive methods of detecting cancer by circulating exosomes are challenged inefficient purification and identification. This study hereby proposed an automated centrifugal microfluidic disc system combined with functionalized membranes (Exo-CMDS) to isolate enrich exosomes, which will then be processed a novel aptamer fluorescence (Exo-AFS) in order detect the exosome surface proteins effective manner. Exo-CMDS features highly qualified yields optimal exosomal concentration 5.1 × 109...
Pancreatic cancer (PC) is one of the deadliest cancers worldwide.Cancer cells secrete excessive numbers exosomes that play essential roles in tumorigenesis.Long non-coding RNAs (lncRNAs) are for progression.However, role lncRNA plasmacytoma variant translocation 1 (PVT1) exosome secretion PC remains to be comprehensively investigated.Thus, nanoparticle tracking analysis and transmission electron microscopy were performed determine secretion.Confocal microscopy, western blots, real-time PCR,...
High-fat diet (HFD) often increases oxidative stress and enhances inflammatory status in the body. Toll-like receptor 4 (TLR4) is widely expressed pancreatic tissues plays an important role pancreatitis. This study aimed at investigating effect of HFD on acute pancreatitis (AP) TLR4-mediated necroptosis inflammation this disease. Weight-matched rats were allocated for 8-week feeding standard chow (SCD) or HFD, then, AP model was induced by infusion 5% sodium taurocholate into biliopancreatic...
Background: An outbreak and worldwide spread of COVID-19 was derived from Wuhan, China where over half the confirmed cases were reported. Protection for special populations at high infection risk such as patients with inflammatory bowel diseases (IBD) is extremely urgent challenging. Methods: We kept alerts since first reported case started to send educational instructional took measures 318 registered IBD (204 UC 114 CD) 20 days earlier shutdown Wuhan. The patients' risks, responses our...
Stress-inducible molecular chaperones have essential roles in maintaining protein homeostasis, but the extent to which they affect overall proteome stability remains unclear. Here, we analyze effects of DnaK (Hsp70) system on Escherichia coli using pulse proteolysis combined with quantitative proteomics. We quantify ∼1,500 soluble proteins and find ∼500 these be protease sensitive under normal growth conditions, indicating a high prevalence conformationally dynamic proteins, forming...
Hydrogen (H2), a new antioxidant, was reported to reduce (•)OH and ONOO(-) selectively inhibit certain proinflammatory mediators product, without disturbing metabolic redox reactions or ROS involved in cell signaling. We herein aim explore its protective effects on acute renal injury sodium taurocholate-induced pancreatitis possible mechanisms. Rats were injected with hydrogen-rich saline (HRS group) normal (SO SAP through tail intravenously (6 mL/kg) compensated subcutaneously (20 after...
Acute renal injury caused by acute necrotizing pancreatitis (ANP) is a common complication that associated with high rate of mortality. Paeoniflorin the active ingredient paeonia radix and exhibits number pharmacological effects, such as anti‑inflammatory, anticancer, analgesic immunomodulatory effects. The present study detected potential treatment effects paeoniflorin on induced ANP in rat model. optimal dose for preventing was determined. Then, possible protective mechanism investigated....
Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are deregulated in hepatocellular carcinoma (HCC) and play a role the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, current understanding lncRNAs NAFLD-associated HCC is limited. In this study, transcriptomic profiling analysis three paired human samples from patients with NAFLD-driven adjacent showed LINC01468 expression was significantly upregulated. vitro vivo gain- loss-of-function experiments...
The accurate diagnosis of pancreatic ductal adenocarcinoma (PDAC) suffers low specify, and sensitivity biomarker detection. In complex biological fluid environments, nonspecific adsorption is prevalent, posing challenges to the detection biomarkers at concentrations. Herein, a highly sensitive selective solution-gated graphene transistor (SGGT) fabricated for miRNA-196a in exosomes diagnose PDAC. antifouling modification on surface gate electrode employed through using bovine serum albumin...
Extract of Rabdosia amethystoides (Benth) Hara (ERA), a traditional Chinese medicine has antibacterial, antiviral, anti-tumor, anti-hepatitis and anti-inflammatory properties. However, the hepatoprotective effects molecular mechanisms ERA on acute liver injury have not been fully elucidated. This study aims to investigate effect protection against induced by Concanavalin A (Con A) its underlying in mice. Mice received (50, 100, 150 mg/kg body weight) gavage before Con intravenous...
This study was conducted to investigate the effect of 4-phenylbutyric acid (4-PBA) on vital organ injury following sodium taurocholate-induced acute pancreatitis (AP) in rats and pertinent mechanism. The serum biochemical indicators key inflammatory cytokines, histopathological damage apoptosis organs rat AP, were evaluated presence or absence 4-PBA. Moreover, mRNA protein levels endoplasmic reticulum stress (ERS) markers assessed. 4-PBA significantly attenuated structural functional organs,...
Endoplasmic reticulum (ER) stress is a particular process with an imbalance of homeostasis, which plays important role in pancreatitis, but little known about how ER implicated severe acute pancreatitis (SAP) induced pancreatic beta-cell injury. To investigate the effect 4-phenylbutyric acid (4-PBA) on injury following SAP and underlying mechanism, twenty-four Sprague-Dawley rats were randomly divided into sham-operation (SO) group, model 4-PBA treatment group. was by infusion 5% sodium...
Abstract Background Colonic migrating motor complexes in the rat constitute two distinct propulsive patterns, pan‐colonic rhythmic long distance contractions ( LDC s), and RPMC s) occurring primarily mid/distal colon. Interstitial cells of Cajal govern their rhythmicity, but occurrence is dependent on neural programs. Our aim was to investigate involvement 5‐ HT 3 4 receptors generation pharmacological control patterns. Methods Effects ‐related drugs colonic patterns were analyzed through...
Previous studies have shown that propofol (PPF) plays a protective role in ischemia-reperfusion (I/R) multiple organs and tissues. This study was aimed to explore the mechanism of PPF ameliorating myocardial injury (MIRI). MIRI model established with Sprague-Dawley rats, pretreatment performed before reperfusion. Creatine kinase isoform (CK-MB), lactate dehydrogenase (LDH), hematoxylin eosin stain were used evaluate severity MIRI. H9c2 cells treated hypoxia/reoxygenation (H/R) simulate I/R...