A5039078808- Advanced biosensing and bioanalysis techniques
- DNA and Biological Computing
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Synthesis and biological activity
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Physics Studies
- Synthesis of Organic Compounds
- Molecular Junctions and Nanostructures
- Computational Drug Discovery Methods
- Marine Sponges and Natural Products
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- Protein Structure and Dynamics
- DNA and Nucleic Acid Chemistry
- Heat shock proteins research
- RNA regulation and disease
- Modular Robots and Swarm Intelligence
- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- RNA Research and Splicing
- Marine Biology and Environmental Chemistry
- Enzyme Structure and Function
- Glycosylation and Glycoproteins Research
- Glutathione Transferases and Polymorphisms
National Sun Yat-sen University
2014-2024
National University of Kaohsiung
2010-2019
Sun Yat-sen University
2014
Changhua Christian Hospital
2010-2012
Tamkang University
2009
I-Shou University
2005-2008
Kun Shan University
2007
Carnegie Mellon University
1999-2000
Case Western Reserve University
1999-2000
The University of Melbourne
1982
Binding energies to pyrrole were determined for a number of main-group and transition-metal cations (both monomer complexes with one ligand dimer two ligands). Experimental data obtained by radiative association kinetics measurements in the Fourier transform ion cyclotron resonance trapping mass spectrometer, along exchange equilibrium determinations (for Mg+ Al+ cases) using benzene as reference ligand. Density functional calculations B3LYP hybrid carried out on all complexes. The indicated...
Binding energies are estimated for the complexes of benzene with first-row transition-metal ions (M+ = Ti+−Cu+) via both kinetic modeling and quantum chemical simulation. A variational transition-state theory model implementing an ion−quadrupole plus ion-induced dipole potential is employed in data collision-induced dissociation these complexes. For Cr+, a global generated its interaction radiative association experiments also modeled. Implementation this analyses indicates only minor...
On the basis of our finding that antitumor effect 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)γ agonist, was, in part, attributable to its ability block glucose uptake independently PPARγ, we used PPARγ-inactive analogue develop novel class transporter (GLUT) inhibitors. This lead optimization led compound 30...
The direct inhibition of bacterial β-glucuronidase (βG) activity is expected to reduce the reactivation glucuronide-conjugated drugs in intestine, thereby reducing drug toxicity. In this study, we report on effects pyrazolo[4,3-c]quinolines acting as a new class βG-specific inhibitors pH-dependent manner. Refinement chemotype for establishing structure–activity relationship resulted identification potential leads. Notably, oral administration...
This work demonstrates two DNA-based logic circuits that behave as a half-adder and half-subtractor. A is composed of an AND gate XOR gate, whereas half-subtractor consists INH gate. The proposed designs are inspired by molecular beacons.
The aims of this study were: (i) to determine whether the severity post-hemiplegic shoulder subluxation in stroke patients correlates with soft-tissue injury; and (ii) measurement cut-off points that are indications for further ultrasound examination injuries these patients.Cross-sectional study.A total 39 subluxation.Shoulder was evaluated by physical examination, radiography ultrasound. Soft-tissue were assessed Subluxation parameters entered into stepwise logistic regression analyses...
Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine that has been recognized as therapeutic target for EML4-ALK fusion-positive nonsmall cell lung cancer (NSCLC) treatment using type I inhibitors such crizotinib to take over the ATP binding site. According Shaw’s measurements, ALK carrying G1202R mutation shows reduced response (IC 50 = 382 nM vs. IC 20 wild-type), whereas L1198F mutant more responsive 0.4 nM). Interestingly, double L1198F/G1202R maintains similar 31 nM)...
The first photoabsorption band of water around 8 eV is studied with the molecular dynamics computer simulation technique under ambient and supercritical conditions. By employment polarizable TAB/10D potential model (Bursulaya, B. D.; Jeon, J.; Zichi, D. A.; Kim, H. J. Chem. Phys. 1997, 108, 3286), electronic structure variations ground low-lying excited states solvation are explicitly accounted for via truncated adiabatic basis-set representation. Compared X̃1A1 → Ã1B1 transition in vacuum,...
This study introduces an optical DNA-based logic circuit that mimics a half-subtractor. The system contains Au-surface immobilized molecular-beacon molecule serves as dual-gate and outputs two series of fluorescence signals following Boolean INH XOR patterns after interacting with one or single-stranded DNA molecules input. To the best our knowledge, reported herein is rather concise compared to other molecular gate systems.
Abstract Over the past decade, DNA has demonstrated remarkable potential in fabrication of molecular logic and arithmetic systems. In this work, a simple DNA-based system mimicking full-subtractor that handles three inputs including one minuend two subtrahends for eight input/output conditions is successfully designed. The whole established by gate molecule input sequences, all made single-stranded sequences.
The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in inflammation and other physiological processes. Because specific inhibitors of p38α p38β MAPK block the production major inflammatory cytokines proteins, represent promising targets for treatment inflammation. In this work, a series based on structural scaffold 4-benzoyl-5-aminopyrazole were analyzed using combination molecular modeling techniques. We generated three-dimensional quantitative...
A series of 4-anilinoquinolinylchalcone derivatives were synthesized and evaluated for antiproliferative activities against the growth human cancer cell lines (Huh-7 MDA-MB-231) normal lung cells (MRC-5). The results exhibited low cytotoxicity Among them, (E)-3-{4-{[4-(benzyloxy)phenyl]amino}quinolin-2-yl}-1-(4-methoxyphenyl) prop-2-en-1-one (4a) was found to have highest in breast cells. Compound 4a causes ATP depletion apoptosis MDA-MB-231 triggers reactive oxygen species (ROS)-dependent...
Abstract GSK3β plays an important role in many physiological functions; dysregulated is involved human diseases such as diabetes, cancer, and Alzheimer's disease. This study uses MD simulations to determine the interaction between a peptide derived from GSKIP, novel interacting protein. Results show that GSKIPtide inlaid binding pocket consisting of α‐helix extended loop near carboxy‐terminal end. hydrophobic, responsible for protein–protein two other proteins: FRAT Axin. The mode closer...
A 72-year-old woman was referred for evaluation of a gastric subepithelial tumor ([Fig. 1]). The patient had no remarkable medical history. Laboratory revealed normal platelet count and coagulation profiles. Following discussion with the patient, diagnostic endoscopic submucosal dissection (ESD) carried out. procedure initiated saline injection using 23-G needle (NM-200L-0423, Olympus, Tokyo, Japan) to raise lesion. Soon after injection, experienced epigastric pain formation hematoma, which...
A 54-year-old woman was referred for endoscopic examination because of an episode tarry stool. Her medical history significant chronic renal failure, which she receiving peritoneal dialysis. Upper endoscopy disclosed ulcerative tumor in the gastric antrum ([Fig. 1]). The first biopsy from ulcer displayed inflammation. An abdominal computed tomography (CT) scan hyperintense, homogeneously enhancing 2]). Abdominal ultrasound showed a hypervascular 3]) and 3-cm, well-defined, hyperechoic with...