A5018676097- Mesenchymal stem cell research
- Endodontics and Root Canal Treatments
- Periodontal Regeneration and Treatments
- Endometrial and Cervical Cancer Treatments
- Suicide and Self-Harm Studies
- Radiomics and Machine Learning in Medical Imaging
- Bone and Dental Protein Studies
- Mental Health Treatment and Access
- Extracellular vesicles in disease
- Dental Radiography and Imaging
- MRI in cancer diagnosis
- Dental Trauma and Treatments
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Bone and Joint Diseases
- Psychosomatic Disorders and Their Treatments
- Oral microbiology and periodontitis research
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Salivary Gland Disorders and Functions
- Bone Tissue Engineering Materials
China Medical University
2015-2025
Jiangsu University
2009-2025
Communication University of China
2025
First Hospital of China Medical University
2010-2025
Changzhou No.2 People's Hospital
2025
Shenyang Center for Disease Control and Prevention
2018-2024
Huazhong University of Science and Technology
2024
National Center for Nanoscience and Technology
2022-2024
Army Medical University
2024
Air Force Medical University
2024
Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer's disease (AD). The blood-brain barrier (BBB) essential keeping toxic substances entering tissues. However, effect of bacteremia on BBB permeability and its underlying mechanism remains unclear. In present study, rats were injected tail vein three times a week eight weeks induce...
Trained immunity refers to the innate immune system building memory-like features in response subsequent infections and vaccinations. Compared with classical tumor vaccines, trained immunity-related vaccines (TIrV) are independent of tumor-specific antigens. Bacterial outer membrane vesicles (OMVs) contain an abundance PAMPs have potential act as TIrV-inducer, but face challenges endotoxin tolerance, systemic delivery, long-term training, tumor-associated macrophage (TAM)-mediated antitumor...
Cuproptosis-based cancer nanomedicine has received widespread attention recently. However, cuproptosis against pancreatic ductal adenocarcinoma (PDAC) is severely limited by stem cells (CSCs), which reside in the hypoxic stroma and adopt glycolysis metabolism accordingly to resist cuproptosis-induced mitochondria damage. Here, we leverage hyperbaric oxygen (HBO) regulate CSC overcoming tumor hypoxia augment elimination efficacy of polydopamine hydroxyethyl starch stabilized...
Antigen-presenting cells (APCs) process tumor vaccines and present antigens as the first signals to T activate anti-tumor immunity, which requires assistance of co-stimulatory second on APCs. The immune checkpoint programmed death ligand 1 (PD-L1) not only mediates escape but also acts a co-inhibitory signal serious dysfunction due high expression PD-L1 APCs in body results inefficiency vaccines. To overcome this challenge, previously established Plug-and-Display vaccine platform based...
Abstract Aim To compare dental pulp responses to capping with iR oot BP Plus and mineral trioxide aggregate ( MTA ) in dogs. Methodology Pulps 36 incisors of three 8‐month‐old beagle dogs were mechanically exposed assigned two experimental groups group group, n = 15 per group) one control 6). Direct was performed using either or . The animals sacrificed 3 months later. Histological sections stained haematoxylin eosin categorized a histologic scoring system. Statistical analysis the...
Regenerative endodontic procedures (REPs) are a new option for the treatment of dental pulp or periapical diseases in permanent teeth with open apices. Histologically, tissues formed root canal after REPs mainly cementum- bone-like mineralised tissues, but not real dentine-pulp complex. Therefore, how to promote complex regeneration and improve clinical effects has become prominent research topic. Stem cells from apical papilla (SCAP) derived that can differentiate into primary odontoblasts...
The aims of this study were to construct the composite poly (L-lactic-co-glycolic acid) (PLGA) scaffold-nucleus pulposus (NP) cells using tissue engineering methods and investigate in vivo performance a canine model. NP isolated from lumbar intervertebral discs beagle dog. cultured, expanded vitro, seeded onto three-dimensional porous PLGA scaffold. was tested 18 dogs that randomly divided into three groups: nucleotomy alone (A), with implantation (B), scaffold/NP (C). X-ray magnetic...
Stem cells from exfoliated deciduous teeth (SHED) possess multipotent differentiation and immunomodulatory properties. They have been used for orofacial bone regeneration autoimmune disease treatment. In this study, we show that acetylsalicylic acid (ASA) treatment is able to significantly improve SHED-mediated osteogenic immunomodulation. Mechanistically, ASA upregulates the telomerase reverse transcriptase (TERT)/Wnt/β-catenin cascade, leading improvement of regeneration, also TERT/FASL...
Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population, possessing multipotent differentiation capacity and immunomodulatory properties. However, the mechanism by which SHED treat immune diseases is not fully understood. Here we show that systemic transplantation of via tail vein ameliorates ovariectomy (OVX)-induced osteopenia reducing T-helper 1 (Th1) 17 (Th17) numbers in recipient OVX mice. Mechanistically, induces activated T-cell apoptosis...
Abstract Introduction Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived cells (ADSCs) are considered one of most appropriate for However, previous experimental data could not reach an agreement on efficacy ADSC transplantation treating in vivo well its mechanism which hinders their further clinical translational application. Methods To explore hADSC administration neurological...
Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer's disease (AD) mainly due to the paracrine of MSCs, but precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes accumulation amyloid-β plaques and neurofibrillary tangles, involves in onset development AD.In present study, we evaluated protective effects explored related-mitochondrial human umbilical cord derived MSC-CM (hucMSC-CM) an AD model vitro.To...
Abstract Background Reconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration crucial determining therapeutic outcomes CSD. Stem cells from apical papilla (SCAP) are neural crest-derived mesenchymal stem (MSCs) that homologous to represent promising source for regeneration. Exosomes, which contain compound bioactive compounds, key factors cell paracrine action. However, roles exosomes derived SCAP (SCAP-Exo) not fully...
Percutaneous sacroiliac screw placement is the main surgical approach to treat unstable posterior pelvic ring injuries. Intraoperative fluoroscopic imaging an important part of safe placement. However, how determine right perspective view challenging. We developed a trigonometric algorithm verify preoperative computed tomography (CT) can be used predict ideal path and safety angle. The normal CT data 30 volunteers from our hospital between September 2021 June 2023 were collected, analyzed...
Glucoamylases (GLL) hydrolyze starch to glucose syrup without yielding intermediate oligosaccharides, but their lack of stability under industrial conditions poses a major limiting factor. Using consensus- and ancestral-based machine-learning tools, functional GLL with six mutations (GLLI73l/T130V/N212V/D238G/N327M/S332P) was constructed that exhibited superior hydrolytic activity relative the wild-type (WT-GLL). An oxidized multi-walled carbon nanotube (oMW-CNT) used as solid support...
This study examined the impact of direct current electric fields (DCEFs) on biological properties stem cells derived from apical papilla (SCAP) and further elucidated underlying mechanisms involved in odontogenic differentiation induced by DCEFs stimulation. The measurement endogenous currents wounded dentine was achieved using a non-invasive vibrating probe system. Two-dimensional (2D) three-dimensional (3D) systems were developed to apply varying strengths. migration direction trajectories...
To evaluate the effects of exosomes derived from stem cells apical papilla (SCAP-Exos) in rats with experimentally induced pulpitis and SCAP-Exos on conversion regulatory T (Tregs) methylation status Foxp3 locus Tregs vitro.SCAP-Exos were isolated identified using transmission electron microscopy, western blotting, nanoparticle tracking analysis. Lipopolysaccharide was used to rats, detected haematoxylin-eosin staining immunofluorescence staining. CD4+ CD25- treated different doses...
Studies on the effects of interventions in patients who have attempted suicide China not reported so far.To describe basic situation surrounding and follow-up to determine whether would be effective reducing repeat attempts.239 had were evaluated emergency departments four general hospitals. They randomized into three groups: cognitive therapy group, telephone intervention control group. Postintervention participants at 3, 6, 12 months separately by following measurements: a detailed...
Mesenchymal stem cell transplantation (MSCT) regulates immune cells, and is a promising therapeutic approach for treating autoimmune diseases. Stem cells from human exfoliated deciduous teeth (SHED) are unique postnatal population the cranial neural crest with high self-renewal, multipotent differentiation, superior immunomodulatory properties. However, mechanisms by which SHED can treat diseases remain unclear. Sjögren's syndrome (SS) an disease histologically characterized lymphocytic...
Multivalent antigen display on nanoparticles can enhance the immunogenicity of nanovaccines targeting viral moieties, such as receptor binding domain (RBD) SARS-CoV-2. However, particle morphology and size current are significantly different from those Additionally, surface patterns not controllable to enable optimization B cell activation. Herein, we employ an icosahedral DNA origami (ICO) a for RBD nanovaccines, achieving diameter like virus (91 ± 11 nm). The addressability permits facile...
Abstract Aim To evaluate the expression of Foxp3‐positive lymphocytes around newly formed tissue after regenerative endodontic treatment ( RET ) in vivo and investigate effects stem cells from apical papilla SCAP on conversion CD 4 + 25 − T to Foxp3 regulatory (Tregs) vitro . Methodology Three 6‐month‐old beagles with nine doubled‐rooted premolars each dog were randomly assigned group control group. was performed periodontitis had been induced experimental immature teeth. months later,...