A5100667374- Chronic Myeloid Leukemia Treatments
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Kruppel-like factors research
- SARS-CoV-2 and COVID-19 Research
- Microtubule and mitosis dynamics
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Alzheimer's disease research and treatments
- Hepatitis B Virus Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- 14-3-3 protein interactions
- RNA regulation and disease
- Bacteriophages and microbial interactions
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Quinazolinone synthesis and applications
- PARP inhibition in cancer therapy
- Spine and Intervertebral Disc Pathology
- Chronic Lymphocytic Leukemia Research
- Telomeres, Telomerase, and Senescence
- Fungal Plant Pathogen Control
Nanjing Medical University
2024-2025
Jiangsu Province Hospital
2024-2025
Tianjin University
2024-2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2025
Soochow University
2013-2024
First Affiliated Hospital of Soochow University
2013-2024
Jiangyin People's Hospital
2016-2024
Nantong University
2023-2024
Academy of Military Medical Sciences
1996-2024
Czech Academy of Sciences, Institute of Biotechnology
2000-2024
Abstract An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2 pathogenesis lethality, but the mechanism remains unclear. In this study, N proteins of were found bind MASP-2, key serine protease in lectin pathway complement activation, resulting aberrant activation aggravated inflammatory lung injury. Either blocking protein:MASP-2 interaction or suppressing can significantly alleviate protein-induced hyper-activation injury vitro vivo . Complement was also observed...
Abstract Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but underlying mechanism remains unclear. In this study, N proteins including severe acute respiratory syndrome coronavirus (SARS-CoV), middle east (MERS-CoV) 2 (SARS-CoV-2), were found bind MASP-2, a key serine protease in lectin pathway complement activation, resulting excessive activation by potentiating MBL-dependent MASP-2 deposition C4b, activated C3 C5b-9....
The high-fat Western diet is postulated to be associated with the onset and progression of Alzheimer's disease (AD). However, role high-fat-diet consumption in AD pathology unknown. This study was undertaken examine intake AD.5XFAD mice, a useful mouse model AD, control wild-type mice were fed (1) or (2) for 10 weeks. effects on cerebral pathology, cognitive function, metabolic parameters compared between each group mice. High-fat significantly enhanced cerebrovascular β-amyloid (Aβ)...
In this study, by in vitro assay and live SARS-CoV-2 virus infection, we provide solid evidence that the NP associates with G3BP1 G3BP2 vivo . could efficiently suppress G3BP-mediated SG formation potentiate viral infection overcoming antiviral innate immunity mediated A549 cell lines conditional knockout mice ( g3bp1 -cKO) mice, which in-depth showing mechanism underlying NP-related pathogenesis through G3BPs.
Antigen-presenting cells (APCs) process tumor vaccines and present antigens as the first signals to T activate anti-tumor immunity, which requires assistance of co-stimulatory second on APCs. The immune checkpoint programmed death ligand 1 (PD-L1) not only mediates escape but also acts a co-inhibitory signal serious dysfunction due high expression PD-L1 APCs in body results inefficiency vaccines. To overcome this challenge, previously established Plug-and-Display vaccine platform based...
The Abl family of mammalian non-receptor tyrosine kinases includes c-Abl and Arg. Recent studies have demonstrated that Arg are activated in the response cells to oxidative stress. This work demonstrates catalase, a major effector cellular defense against H2O2, interacts with results show H2O2 induced binding catalase. SH3 domains bound directly catalase at P293FNP site. phosphorylated Tyr231 Tyr386 vitro H2O2. functional significance interaction is supported by demonstration deficient both...
Abstract Recent studies suggest that cell therapy may be an effective way to repair intervertebral disc degeneration. As a strong immune suppressor, TGF-β1 has been shown inhibit inflammation respond effectively. The objective of this study was explore the effects during bone marrow mesenchymal stem cells-based for In vitro assays demonstrated co-culturing nucleus pulposus cells with resulted in significantly higher levels TGF-βl secretion. This increase inhibited IκB phosphorylation and...
Summary Background Coronavirus infectious disease 2019 (COVID-19) has developed into a global pandemic. It is essential to investigate the clinical characteristics of COVID-19 and uncover potential risk factors for severe reduce overall mortality rate COVID-19. Methods Sixty-one critical patients admitted intensive care unit (ICU) 93 non-ICU at Huoshenshan Hospital (Wuhan, China) were included in this study. Medical records, including demographic, platelet counts, heparin-involved...
Kai-Xin-San (KXS) is a traditional Chinese medicinal formula composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii and Poria for relieving major depressive disorder Alzheimer’s disease in medicine (TCM) clinics. Previous studies on the antidepressant mechanism KXS mainly focused neurotransmitter neurotrophic factor regulation, but few reports exist neuronal inflammation regulation. In current study, we found that exerted effects chronic unpredictable mild stress-induced...
The c-Abl and Arg tyrosine kinases are activated in the cellular response to oxidative stress. present studies demonstrate that associate with glutathione peroxidase 1 (GPx1) this interaction is regulated by intracellular oxidant levels. SH3 domains bind directly a proline-rich site GPx1 at amino acids 132–145. also functions as substrate for c-Abl- Arg-mediated phosphorylation on Tyr-96. results further show stimulate GPx activity these contribute GPx-mediated protection of cells against...
Catalase is a major effector in the defense of aerobic cells against oxidative stress. Recent studies have shown that catalase activity stimulated by c-Abl and Arg tyrosine kinases. Little, however, otherwise known about mechanisms responsible for regulation. The present work demonstrates mouse deficient both exhibit increased stability. results also show subject to ubiquitination degradation 26S proteosome. Significantly, dependent on c-Abl- Arg-mediated phosphorylation Y231 Y386. In...
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Excessive inflammation causes a wide range of diseases. Here, we found that stimulating TRPV1+ nerves at the nape activated nucleus solitary tract and C1 neurons in brainstem via somatosensory afferent pathway, rapidly induced secretion corticosterone, drove vagal-adrenal axis to release serum catecholamines, autonomic-splenic reflex suppress cytokine production. RNA sequencing (RNA-seq) analysis revealed significantly changed expression genes enriched multiple pathways related inflammatory...
Blood-contacting devices serve as a mainstay in clinical treatment, yet thrombosis remains major cause of device failure and poses risks to patient health. In this study, we developed diselenide cross-linker, N,N'-bis(methacryloyl)selenocystamine (BMASC), incorporated into poly(sulfobetaine methacrylate) (PSBMA) microgels (defined BSM) create an enzyme-mimetic zwitterionic microgel coating (BSMC). The superhydrophilicity PSBMA provides outstanding antifouling performance, while the bonds...
This study aimed to delineate the temporal tendency in age and gender burden of psoriasis China, spanning from 1990 2021, encompassing metrics such as incidence, prevalence, disability-adjusted life years (DALYs). Furthermore, it sought contrast these findings with global disease burden. It also purposed assess impacts age, time, birth cohort, well forecast China for upcoming 15 years. Utilizing open-access data Global Burden Disease (GBD) database this comprehensively examined globally. In...
The nonreceptor tyrosine kinase c-ABL controls cell growth but its contributions in solid tumors are not fully understood. Here we report that the Polo-like PLK1, an essential mitotic regulator, is important downstream effector of regulating cervical cancer. interacted with and phosphorylated PLK1. Phosphorylation PLK1 by inhibited ubiquitination degradation enhanced activity, leading to cell-cycle progression tumor growth. Both were overexpressed carcinoma. Notably, phosphorylation...