A5100362335- Microtubule and mitosis dynamics
- Plant Pathogens and Fungal Diseases
- melanin and skin pigmentation
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Cellular Mechanics and Interactions
- SARS-CoV-2 and COVID-19 Research
- Mycotoxins in Agriculture and Food
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Zebrafish Biomedical Research Applications
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Cell death mechanisms and regulation
- Neurobiology and Insect Physiology Research
- Mycorrhizal Fungi and Plant Interactions
- Autophagy in Disease and Therapy
- Insect Utilization and Effects
- Cell Adhesion Molecules Research
- Pneumonia and Respiratory Infections
- Gold and Silver Nanoparticles Synthesis and Applications
- Curcumin's Biomedical Applications
- Chronic Myeloid Leukemia Treatments
- Bacteriophages and microbial interactions
University of Oklahoma Health Sciences Center
2023
Huaihua University
2023
Zhongshan Hospital of Xiamen University
2023
Fudan University
2023
Sichuan Agricultural University
2020-2022
Xiamen University
2011-2022
Nanjing University
2022
Dian Diagnostics (China)
2022
Bohai University
2022
Shenyang Medical College
2019
Tyrosinase (EC 1.14.18.1), also known as polyphenol oxidase (PPO), is a key enzyme in pigment biosynthesis of organisms. The inhibitory effects propyl gallate on the activity mushroom tyrosinase and pericarp browning harvested longan fruits relation to phenolic metabolism were investigated. results showed that could potently inhibit diphenolase tyrosinase. inhibitor concentration leading 50% lost (IC50) was determined be 0.685 mM. Kinetic analyses reversible mixed type this enzyme....
Non-small cell lung cancer (NSCLC) is the most common type of with a poor prognosis. We previously found that protein disulfide isomerase family 6 (PDIA6) upregulated in squamous carcinoma (LSCC). This study aimed to elucidate clinical relevance, biological functions, and molecular mechanisms PDIA6 NSCLC. The expression NSCLC was assessed using TCGA database, western blotting, immunohistochemistry. Correlations clinicopathological survival features were evaluated. functions regulating...
A portable detection method based on a target-responsive hydrogel for target recognition and gold nanorods as multicolor signal readout circuit was developed.
A facile route is presented for fabricating a new class of nanomimics that overexpress hepatitis B virus (HBV) receptor by natural biosynthetic procedure against HBV infection. nine-transmembrane HBV-specific receptor, human sodium taurocholate co-transporting polypeptide (hNTCP), was engineered to naturally immobilize it onto the cellular surface and subsequently trigger budding hNTCP-anchoring membrane vesicles (hNTCP-MVs) favor virion. hNTCP-MVs could rapidly block infection in cell...
Many species of the genus Bipolaris are important plant pathogens and often cause leaf spot, root rot, seedling blight in an extremely wide range hosts around world. In recent years, maize spot caused by has frequently occurred with complex symptoms is becoming increasingly serious Sichuan Province China. To investigate population diversity spp. their corresponding maize, 747 samples were collected from 132 sampling sites 19 administrative districts 2011 to 2018. Based on morphological...
This study aimed to identify novel tyrosinase inhibitory peptides from collagen of donkey by combining in silico screening with vitro activity verification, and elucidate inhibition mechanism based on molecular docking dynamics simulation. Three tripeptides, that is, Asp-Gly-Leu (DGL), Gly-Ala-Arg (GAR), Ser-Asp-Trp (SDW) were identified exerted potent activities, IC50 values 0.47 ± 0.01 mM, 1.13 0.04 2.08 respectively. Each three had hydrophobic amino acids could stably closely bind the...
In insects, tyrosinase plays important roles in normal developmental processes, such as cuticular tanning, scleration, wound healing, production of opsonins, encapsulation and nodule formation for defense against foreign pathogens. Thus, may be regarded a potential candidate novel bioinsecticide development. A family alkyl 3,4-dihydroxybenzoates (C6–C9), new tyrosinsase inhibitors, were synthesized. Their inhibitory effects on the activity have been investigated. The results showed all them...
Silibinin has been shown to attenuate cognitive dysfunction and inhibit amyloid-beta (Aβ) aggregation in Alzheimer's disease (AD) models. However, the underlying mechanism by which silibinin improves cognition remains poorly understood. In this study, we investigated effect of on β-secretase levels, Aβ enzymatic degradation, oxidative stress brains APP/PS1 mice with impairments. Oral administration for 2 months significantly attenuated deficits Y-maze test, novel object recognition Morris...
To understand the genomic evolution and adaptation strategies of fungi to subseafloor sedimentary environments, we
Micro/nanotopographies (MNTs) have been reported to enhance the osseointegration of biomaterials and modulate cell functions, but underlying mechanisms are incompletely understood. We hypothesized that transient receptor potential vanilloid 4 (TRPV4) may mediate topographically induced osteoblastic differentiation bone marrow stem cells (BMSCs) by regulating NFATc1 Wnt/β-catenin signaling. To test this hypothesis, murine BMSCs were cultured on polished titanium (Ti) discs (PT) Ti carrying...
The human liver chimeric mouse with primary hepatocytes (PHHs) engraftment has been demonstrated to be a useful animal model study hepatitis B virus (HBV) pathogenesis and evaluate anti-HBV drugs. However, the disadvantages of using PHHs include inability for cellular expansion in vitro, limited donor availability, individual differences, ethical issues, necessitating development alternatives. To obtain vitro expandable hepatocytes, we optimized hepatic differentiation procedure progenitor...
Overexpression of Aurora A and B has been reported in a wide range tumor types, including gastric cancer. Anti-angiogenesis considered as an important therapeutic modality advanced Here we identified novel compound TY-011 with promising antitumor activity by targeting mitotic kinases (Aurora B) angiogenic receptor tyrosine kinase (VEGFR2). HTRF® KinEASE™ assay was used to detect the effect against A, VEGFR2 activities. Docking simulation study performed predict binding mode kinases. CCK-8...
Cytoskeletal microtubules (MTs) are nucleated from γ-tubulin ring complexes (γTuRCs) located at MT organizing centers (MTOCs), such as the centrosome. However, exact regulatory mechanism of γTuRC assembly is not fully understood. Here, we showed that nonreceptor tyrosine kinase c-Abl was associated with and phosphorylated γ-tubulin, essential component γTuRC, mainly on Y443 residue by in vivo (immunofluorescence immunoprecipitation) or vitro (surface plasmon resonance) detection. We further...
Abstract Oncolytic adenoviruses (OAs)‐based virotherapy can regulate the tumor microenvironment, providing a rational strategy for combination treatment with other therapy techniques, such as transcatheter arterial embolization (TAE). Here, novel, validated viroembolization (TAVE) strategy—a calcium alginate hydrogel microsphere OA encapsulated (OA@Alg beads) to achieve of TAE oncolytic enhance and prolong antitumor efficacy in hepatocellular carcinoma treatment—is described. The OA@Alg...
Blueberry leaf spots and stem cankers caused by Pestalotiopsis spp. have become a serious threat for the production of blueberry in Sichuan Province. To characterize etiology diseases connected with these fungi, samples showing spot canker symptoms were collected from 12 main blueberry-growing areas Province 2015 to 2020 used pathogen isolation. In total, 91 fungal isolates obtained preliminary morphological identification 48 representative strains selected further pathogenicity test...
Hepatitis B virus (HBV) is the leading cause of liver disease and hepatic carcinoma (HCC). Approximately 350 million people worldwide are infected with HBV at risk chronicity. An efficient HBV-tolerant murine model that mimics infection in humans desirable for HBV-related research. In this study, we investigated established a by hydrodynamic injection (HDI) pAAV/HBV into tail vein AAVS1 site element-transgenic mice. 80% injected mice, serum level HBsAg reached 103-4 IU/ml persisted more than...
Konjac (Amorphophallus konjac) is a perennial herbaceous plant of the Araceae family, cultivated mainly in south-western China and used extensively for weight loss (Chua et al. 2010). In June 2022, leaf blight was detected on 2,00 ha A. konjac plantation Chenxi County, Huaihua City, Hunan Province. It infected almost 20% area under cultivation tends to occur each year during warm, humid weather from May July, causing significant economic losses production. There were small brown spots leaves...