A5101626048- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- Chemical and Physical Studies
- Bone Metabolism and Diseases
- Molecular Biology Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Brucella: diagnosis, epidemiology, treatment
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Bone health and osteoporosis research
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Cellular Mechanics and Interactions
- Tendon Structure and Treatment
- Yersinia bacterium, plague, ectoparasites research
- Heat shock proteins research
- Orthopaedic implants and arthroplasty
- MicroRNA in disease regulation
Xinjiang Medical University
2018-2024
First Affiliated Hospital of Xinjiang Medical University
2018-2024
Hainan Medical University
2024
China Medical University
2011-2022
Affiliated Hospital of Southwest Medical University
2019-2021
Yangzhou University
2017
Taizhou Second People's Hospital
2017
Abstract Objective This study aimed to identify the potential inflammatory molecular biomarkers that could be utilized for early prediction of different subtypes tuberculosis (TB) in adults. Methods Plasma samples were obtained from a cohort adults diagnosed with 48 cases active TB, including drug-susceptible TB (S-TB, n = 28), multidrug-resistant (R-TB, 20), latent infection (LTBI, as well control group healthy individuals without any (HC, 20). The expression level 92 inflammatory-related...
Micro/nanotopographies (MNTs) have been reported to enhance the osseointegration of biomaterials and modulate cell functions, but underlying mechanisms are incompletely understood. We hypothesized that transient receptor potential vanilloid 4 (TRPV4) may mediate topographically induced osteoblastic differentiation bone marrow stem cells (BMSCs) by regulating NFATc1 Wnt/β-catenin signaling. To test this hypothesis, murine BMSCs were cultured on polished titanium (Ti) discs (PT) Ti carrying...
As a novel class of noncoding RNAs, circular RNAs (circRNAs) have been recently reported to be involved in cell development and function. However, the functional role circRNAs hepatocellular carcinoma (HCC) remains unclear. In present study, we found that expression human circ_101141 was upregulated HCC tissues cells. addition, downregulation dramatically inhibited proliferation, migration, invasion by using bioinformatics tools, potential target predicted. Mechanistic investigations...
Chronic infection induced by immune tolerance to hepatitis B virus (HBV) is one of the most common causes hepatic cirrhosis and hepatoma. Fortunately, application therapeutic vaccine can not only reverse HBV-tolerance, but also serve a potentially effective strategy for treating chronic (CHB). However, clinical effect currently developed CHB optimistic due weak immunogenicity. Given that human leukocyte antigen CTLA-4 owns strong binding ability surface B7 molecules (CD80 CD86) presenting...
Analysis of gene expression can provide important information related to prognostic or predictive factors in clinical work. DNA RNA isolated from formalin fixed and paraffin-embedded tissue is generally accepted be difficult due degradation crosslinking. Factors affecting mRNA quality such as fixation length autolysis period before fixation/freezing have not been systematically addressed. In this study, we analyzed the effect on several reference genes formalin-fixed (FFPE) colorectal...
To investigate the effects and possible mechanisms of negative air ions(NAIs) on blood pressure, oxidative stress, inflammatory status in spontaneous hypertension rats(SHR).
<title>Abstract</title> <bold>Objective</bold> The objective of this study was to identif<underline>y the </underline>potential inflammatory molecular biomarkers that could be utilized for early prediction different subtype tuberculosis (TB) in adults. <bold>Methods</bold> Plasma samples were obtained from a cohort adults diagnosed with 48 cases <bold>active (</bold>TB), including drug susceptible TB (DS-TB, n=28), multidrug resistant (MDR-TB, n=20), latent infection (LTBI, as well control...
The present study investigated the expression of Toll-like receptor 4 (TLR4) and proteins involved in its associated signaling pathways patients with classic Kaposi's sarcoma (KS) acquired immune deficiency syndrome (AIDS)-associated KS (AIDS-KS) Xinjiang Autonomous Region China. A total 35 were enrolled between May 2011 July 2013, including 26 cases AIDS-KS 9 KS. Another 10 healthy subjects Uygur ethnic group included normal control group. tissues subjected to hematoxylin eosin staining...
Abstract Background The detection of cell-free DNA (cfDNA) is a promising early diagnosis method for hepatocellular carcinoma (HCC). We validated the cfDNA-based comprehensive diagnostic model (HIFI) and explored its value in prediction HCC. Methods cfDNA was performed 126 patients, results HIFI were obtainedand compared with HCC markers. Moreover, we conducted comparison between predictive ability aMAP score at 10 months follow-up. Results Chi-square test Kappa analysis showed that...
现对新疆防治肉毒中毒、霍乱、戊型肝炎和脊髓灰质炎流行进行了历史回顾。.
Objective To investigate the effects of changes miR-126 and spouty related EVH, domain containing proteinl(SPRED1) after transient ischemic attack(TIA)on prognostic value for pathogenesis secondary cerebral infarction. Methods Retrospective analysis clinical data 106 patients with TIA was performed.The expression levels miR-126, SPRED1 vascular endothelial growth factor(VEGF)in peripheral blood were detected at 3 h, 6 h 12 onset respectively.The specificity sensitivity in diagnosis...
Objective To investigate the clinical features of brucellosis in children. Methods A total 72 cases with childhood admitted to First Affiliated Hospital Xinjiang Medical University from January 2010 October 2018 were selected summarize data. Results Among cases, male-to-female ratio was 2.13∶1. The disease highly occurred children at 12-17 years old (41.7%) , farming and stockbreeding areas, incidence peak May August each year. main manifestations fever, joint pain, anorexia,...