A5004246268- Prostate Cancer Treatment and Research
- vaccines and immunoinformatics approaches
- Parasitic infections in humans and animals
- Brucella: diagnosis, epidemiology, treatment
- Monoclonal and Polyclonal Antibodies Research
- Congenital Anomalies and Fetal Surgery
- Galectins and Cancer Biology
- Prostate Cancer Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Supercapacitor Materials and Fabrication
- Advanced Polymer Synthesis and Characterization
- Cancer, Lipids, and Metabolism
- Advancements in Battery Materials
- biodegradable polymer synthesis and properties
- Bacteriophages and microbial interactions
- Fish Ecology and Management Studies
- Epigenetics and DNA Methylation
- Toxoplasma gondii Research Studies
- Animal Virus Infections Studies
- Pediatric health and respiratory diseases
- Cancer Genomics and Diagnostics
- Eosinophilic Esophagitis
- Burkholderia infections and melioidosis
Qinghai University
2025
Ministry of Agriculture and Rural Affairs
2025
Beijing Friendship Hospital
2013-2024
Beijing Municipal Education Commission
2024
First Affiliated Hospital of Xinjiang Medical University
2015-2024
Xinjiang Medical University
2015-2024
Capital Medical University
2013-2024
China Institute of Water Resources and Hydropower Research
2024
IHE Delft Institute for Water Education
2022-2023
China University of Petroleum, East China
2022
Significance Formation of androgen receptor splicing variant 7 (AR-V7), a constitutively active form AR, plays key role in the resistance prostate cancer to hormone therapy. However, mechanisms that regulate AR-V7 generation are poorly understood. Here, we identified new for histone demethylase JMJD1A (Jumonji domain containing 1A) formation cells. We found facilitated recruitment factor, heterogeneous nuclear ribonucleoprotein F, alternative and AR-V7. The findings suggest targeting may...
Abstract Brucella , a gram-negative intracellular bacterium, causing Brucellosis, zoonotic disease with range of clinical manifestations, from asymptomatic to fever, fatigue, loss appetite, joint and muscle pain, back severe patients have developed serious diseases affecting various organs. The mRNA vaccine is an innovative type that anticipated supplant traditional vaccines. It widely utilized for preventing viral infections tumor immunotherapy. However, research regarding its effectiveness...
Well-defined ethyl cellulose-graft-poly(ε-caprolactone) (EC-g-PCL) graft copolymers were successfully synthesized via ring-opening polymerization (ROP) of ε-caprolactone (CL) with an cellulose (EC) initiator and a tin 2-ethylhexanoate (Sn(Oct)2) catalyst in xylene at 120 °C. Then, novel cellulose-graft-poly(ε-caprolactone)-block-poly(l-lactide) (EC-g-PCL-b-PLLA) graft-block prepared by ROP l-lactide (L-LA) hydroxyl-terminated EC-g-PCL macroinitiator Sn(Oct)2 bulk Various block lengths...
Well-defined cellulose-based dual graft molecular brushes, composed of ethyl cellulose-graft-poly(N,N-dimethylaminoethyl methacrylate)-graft-poly(ε-caprolactone) (EC-g-PDMAEMA-g-PCL), have been prepared by ring-opening polymerization (ROP) and atom transfer radical (ATRP). Unlike other brush copolymers, the new brushes show some unique physicochemical properties multifunction due to their topological structures. These biocompatible copolymers self-assembled micelles in aqueous solution. Upon...
The androgen receptor (AR) pathway plays a central role in the development of castration-resistant prostate cancer (CRPC). histone demethylase JMJD1A has been shown to regulate activities AR and c-Myc transcription factors promote progression. Here, we report that protein stability is controlled by ubiquitin ligase STUB1. High levels were strongly correlated with low STUB1 human CRPC specimens. inhibited activity, AR-V7 levels, cell growth partly through degradation JMJD1A. Furthermore,...
Abstract Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it difficult to eliminate with current medical treatment. Therefore, multi-epitope vaccine (MEV) should be designed prevent infection. this purpose, we applied the reverse vaccinology approach from Omp10, Omp25, Omp31 and BtpB. Finally, obtained 13 cytotoxic T lymphocyte (CTL) epitopes, 17 helper (HTL) 9 linear B cell 2 conformational epitopes for further study. To keep...
Novel brush copolymers with poly(2-hydroxyethyl methacrylate) (PHEMA) as polymer backbone and diblock copolymer consisting of crystallizable poly(ε-caprolactone) (PCL) poly(ethylene oxide) (PEO) side chains were synthesized successively by the combination ring-opening polymerization (ROP) coupling reaction. The molecular weights methacrylate)-graft-poly(ε-caprolactone) (PHEMA-g-PCL) controllable, weight distributions in range 1.28−1.32. reaction efficiency hydroxyl-terminated mPEO (mPEO-OH)...
Background This study aims to analyze the clinical characteristics and treatment outcomes of 590 patients with brucellosis in Xinjiang, China. Methodology principal findings The characteristics, laboratory findings, complications prognosis infected were retrospectively analyzed. These had a mean age 44.24 ± 15.83 years 60.5% having history close contacting cattle sheep. Of them, 53.6% (316 /590) acute phase 21.5% chronic phase. Agglutination test showed 98.5% positive 34% blood culture...
This study is to investigate the role of regulatory B (Breg) cells in cervical cancer. In total, 70 cases cancer, 52 intraepithelial neoplasia (CIN), and 40 normal controls were enrolled. The percentage Breg was detected by flow cytometry. Serum levels IL-10 measured ELISA. correlation between clinical characterizations cancer analyzed. inhibition effect on CD8 + T tested blocking vitro . CD19 CD5 CD1d level patients with or CIN significantly higher than those control group (<mml:math...
All the time, echinococcosis is a global zoonotic disease which seriously endangers public health all over world. In order to speed up development process of anti- Echinococcus granulosus vaccine, at same it can also save economic cost. this study, immunoinformatics tools and molecular docking methods were used predict screen antigen epitopes , design multi-epitope vaccine containing B- T-cell epitopes. The could activate B lymphocytes produce specific antibodies theoretically, protect human...
Background: This study aimed to describe the aberrations of DNA damage repair genes and other important driving in Chinese patients with metastatic castration-resistant prostate cancer (mCRPC) using circulating tumor (ctDNA) sequencing evaluate associations between clinical outcomes multiple therapies key genomic alterations mCRPC, especially genes. Patients Methods: A total 292 mCRPC enrolled from 8 centers. Multigene targeted was performed on 306 ctDNA samples 23 matched biopsies. The...
The development of an effective multivalent vaccine against SARS-CoV-2 variants is important means to improve the global public health situation caused by COVID-19. In this study, we identified antigen epitopes main epidemic and mutated virus strains using immunoinformatics approach, screened out 8 cytotoxic T lymphocyte (CTLEs), 17 helper (HTLEs), 9 linear B-cell (LBEs) 4 conformational (CBEs). population coverage CTLEs HTLEs was 93.16% 99.9% respectively. These were spliced together...
Abstract In this paper, we present a high peak power passively Q-switched intracavity frequency-doubled green laser based on an efficient LED-pumped Nd:YAG dual-rod module. quasi-continuous wave (QCW) running operation, the average output of fundamental at 1064 nm reaches as 20.98 W repetition rate 50 Hz with maximum single pulse energy 419.6 mJ, corresponding to optical conversion efficiency 38.8% and slope 41%. Under conditions, is 1.4 MW duration 88 ns. Through fine-tuning incident angle...
The degradation of organic matter using TiO2 nanotube photocatalytic technology is limited by the short lifetime and diffusion radius generated hydroxyl radicals, decreasing removal efficiency. This study developed a chlorine radical-coupled photoelectrocatalytic system, significantly enhancing performance arrays in removing sulfonamide antibiotics (SAs) from cold-water aquaculture systems. highest rates were observed at 5 mM NaCl 15 NaNO3. When SA concentrations 0.1–10 mg/L, efficiency...
Th9 cells have been reported to contribute immune responses; however, the role of in Echinococcus granulosus infection is unknown. This study determine whether and IL-9 are involved human infection. Compared with healthy controls (HC group), mRNA levels PU.1, IL-9, GATA-3 were significantly increased patients before therapy (CE as revealed by qRT-PCR. Flow cytometry analysis showed that percentages Th2 CE group higher. The IL-4, IL-10, TGF- β also increased, detected CBA assay. positively...
The DNA damage response (DDR) pathway is a promising target for anticancer therapies. androgen receptor and myeloblastosis transcription factors have been reported to regulate expression of an overlapping set DDR genes in prostate cancer cells. Here, we found that histone demethylase JMJD1A regulates different largely through c-Myc. Inhibition delayed the resolution γ-H2AX foci, reduced formation foci containing ubiquitin, 53BP1, BRCA1 or Rad51, inhibited reporter activity double-strand...
In view of the high infection rate Helicobacter pylori, a safe and effective vaccine is urgently needed. Recent trends in design have shifted toward specific epitope-based vaccines. this study, by using different immunoinformatics approaches, total eight linear B cell epitopes, four HTL three CTL epitopes FlaA UreB proteins H. pylori G27 strain were screened out, we also predicted conformational two proteins. Then, dominant sequentially linked appropriate linkers, cytotoxic T...