A5001475335- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Toxoplasma gondii Research Studies
- Pancreatic and Hepatic Oncology Research
- Urological Disorders and Treatments
- Parasite Biology and Host Interactions
- Sulfur Compounds in Biology
- Parasites and Host Interactions
- Renal cell carcinoma treatment
- Pancreatitis Pathology and Treatment
- Metabolomics and Mass Spectrometry Studies
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Gut microbiota and health
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Listeria monocytogenes in Food Safety
Qinghai University
2015-2025
Qinghai University Affiliated Hospital
2015-2025
Qinghai Institute for Endemic Diease Prevention and Control
2018-2023
Graduate School USA
2013
Introduction Alveolar echinococcosis (AE) is a chronic zoonotic disease caused by the larvae of Echinococcus multilocularis ( E. ). The current chemotherapy for AE relies on albendazole and mebendazole, which exhibit only parasitostatic rather than parasiticidal effects. Therefore, there need to find new anti-Echinococcosis drugs. Pseudolaric acid B (PAB) has been described have strong antiparasitic However, in-depth mechanism PAB acts against remains unclear. Methods To evaluate effect...
// Lei Zhou 1, 2, 3 , Zhixin Wang 4 Xinsen Xu 2 Yong Wan Kai Qu Haining Fan Qiangpu Chen 1 Xuejun Sun Chang Liu Department of Hepatobiliary Surgery, The Affiliated Hospital Binzhou Medical University, Binzhou, China First Hospital, School Medicine, Xi’an Jiaotong Xi’an, General Hepatopancreatobiliary Qinghai Xining, Correspondence to: Chen, e-mail: drcqp@hotmail.com Sun, sunxj@mail.xjtu.edu.cn Liu, liuchangdoctor@163.com Keywords: Nek7, hepatocellular carcinoma, cell...
Hepatocellular carcinoma (HCC) is the third-leading cause of cancer deaths globally. Although considerable progress has been made in treatment, clinical outcomes HCC patients are still poor. Therefore, it necessary to find novel prognostic factors upon which prevention and treatment strategies can be formulated. Ficolin-3 (FCN3) protein a member human ficolin family. It activates complement through pathways associated with mannose-binding lectin-associated serine proteases. Herein, we...
We are concerned with the existence and asymptotic behavior of multiple radial sign-changing solutions nodal characterization for a Kirchhoff-type problem involving nonlinearity $|u|^{p-2}u(2<p<4)$ in $\mathbb{R}^3$. By developing some useful analysis techniques introducing novel definition Nehari manifold auxiliary system equations, we show that, any positive integer $k$, has solution $u_k^b$ changing signs exactly $k$ times. Furthermore, energy is strictly increasing as well behaviors...
Maximizing the pharmacological efficacy of albendazole (ABZ), an anti-echinococcosis drug, is essential in long-term treatment patients with echinococcosis. As a weakly alkaline ABZ has pH-dependent solubility that decreases dramatically from gastric fluid (pH 1.4) to intestinal 6.5), where it absorbed. In this study, we endeavored develop optimized tablet formulation improve its dissolution and oral bioavailability two aspects: faster initial pH condition (i.e., "spring") more prolonged...
Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in liver. It a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease currently not available due to its long asymptomatic incubation period. In study, proton nuclear magnetic resonance (
In our study, we investigated whether circulating T follicular helper (Tfh) and the related cytokines are involved in human cystic echinococcosis (CE). A total of 64 patients with CE 30 healthy controls were enrolled this study. Percentages CCR7loPD-1hi cells within CXCR5+ CD4+ (circulating Tfh cells) detected by flow cytometry. Levels IL-21 IL-4 peripheral blood cytometric bead array. The mRNA expression IL-21, IL-4, Bcl-6, Blimp-1 mononuclear (PBMCs) measured real-time PCR. IgG1, IgG2,...
Echinococcosis is a worldwide anthropozoonosis which highly endemic over large animal husbandry areas in northwestern China. The current clinical therapeutic medicine against echinococcosis albendazole, although it caused serious side effects patients. component traditional Chinese herb medicine, Sophora moorcroftiana alkaloids (SA), thought to be potential drug treat echinococcosis. In order explore the effect and mechanism of SA treatment echinococcosis, we established model treated rats...
Alveolar echinococcosis (AE) is a chronic infectious parasitic disease that fatal and still being neglected. Currently, the AE treatment recommended by WHO complete excision of lesions, followed oral administration albendazole (ABZ), only effective first-line anti-AE drug, for two years. Unfortunately, lesions impossible in most cases, leaving long-term use ABZ as alternative. However, about one-third patients experience remission or cure with such treatments, largely because low...
Alveolar echinococcosis (AE) is a fatal zoonosis caused by the larvae of Echinococcus multilocularis. However, current chemotherapy treatment options are based on benzimidazoles [albendazole (ABZ) and mebendazole], which have limited efficacy. Therefore, novel drugs necessary for this disease.The anthelmintic effects crocin were tested E. multilocularis metacestodes, germinal cells protoscoleces in vitro. Human foreskin fibroblasts (HFFs) Reuber rat hepatoma (RH) used to assess cytotoxicity....
Abstract Background Alveolar echinococcosis (AE) is a serious parasitic disease caused by the larvae of Echinococcus multilocularis. It less common but substantially more deadly 2 major diseases that can occur globally are concentrated in central Asia. Methods We analyzed parasite circulating cell-free DNA (cfDNA) 149 plasma samples using sequencing–based method (105 AE, 16 cystic echinococcosis, 4 liver cancer, gallstones, and 20 healthy volunteers). After identifying Echinococcus-specific...
Alveolar echinococcosis (AE) is considered as a fatal zoonosis caused by the larvae of Echinococcus multilocularis. The lungs and brain are most common metastatic organs. We report human case hepatic alveolar accompanied lung metastasis. In particular, patient had history tuberculosis lesions were easily misdiagnosed abscesses. liver underwent radical resection confirmed pathological examination. no surgical complications after operation was discharged symptomatic treatment. Unfortunately,...
Abstract Background Alveolar echinococcosis (AE) is a chronic zoonosis caused by the larval form of Echinococcus multilocularis ( E. ). Current chemotherapy against AE has relied on albendazole and mebendazole, which only exhibit parasitostatic not parasiticidal efficacy. Therefore, novel compounds for treatment this disease are needed. Methods Phosphoglucose isomerase (PGI) assays were used compound screening seven neonicotinoids. The anti-parasitic effects thiacloprid then evaluated...
Transarterial chemoembolization (TACE) is the standard treatment for most intermediate-to-advanced stage hepatocellular carcinoma. With ongoing development of interventional therapies, TACE in combination with different protocols being explored. A network meta-analysis to collect recent evidence this field required. We searched PubMed, Web Science, Cochrane Central Register Controlled Trials, Embase, Chinese National Knowledge Infrastructure database, Library, and Wanfang database from their...
Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by the infection of Echinococcus multilocularis ( E. ) larvae. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) produces inhibitory signals and induces T cell exhaustion, thereby inhibiting parasiticidal efficacy liver immune system. Therefore, purpose this study to explore how T-cell exhaustion contributes AE whether blocking CTLA-4 could reverse exhaustion. Here we discovered that expression was increased in infiltrating margin...
Abstract Purpose Biliary leakage caused by cystobiliary communication (CBC) is a common clinical concern. This study sought to identify predictors of CBC in hepatic cystic echinococcosis (HCE) patients undergoing hydatid liver cyst surgery and establish nomograms predict CBC. Methods A predictive model was established training cohort 310 HCE diagnosed between January 2013 May 2017. Upon revision the records parameters imaging features these patients, lasso regression used optimize feature...
Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients northern hemisphere.The expression levels 20 cytokines associated with AE infection were measured enzyme-linked immunosorbent assay, and correlations between these analysed R programming language.Serum cytokine differed among individuals both patient healthy control groups. The results showed obvious...