A5100630055- Nanoplatforms for cancer theranostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced biosensing and bioanalysis techniques
- Nanofluid Flow and Heat Transfer
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Cancer Research and Treatments
- Mesenchymal stem cell research
- Inflammatory Biomarkers in Disease Prognosis
- Advancements in Battery Materials
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Supercapacitor Materials and Fabrication
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- Advanced Battery Materials and Technologies
- Parkinson's Disease Mechanisms and Treatments
- Plant Reproductive Biology
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Lipids, and Metabolism
- Outsourcing and Supply Chain Management
- Pancreatic and Hepatic Oncology Research
Shandong Normal University
2016-2025
Second Affiliated Hospital of Dalian Medical University
2024-2025
Dalian Medical University
2024-2025
UMass Memorial Medical Center
2024
University of Massachusetts Chan Medical School
2023-2024
Chongqing Cancer Hospital
2024
Chongqing University
2024
Second Military Medical University
2023-2024
Changhai Hospital
2023-2024
Tianjin University of Science and Technology
2022-2024
From 2003 to 2005, standardised 5-year cancer survival in China was much lower than developed countries and varied substantially by geographical area. Monitoring population-level is crucial the understanding of overall effectiveness care. We therefore aimed investigate statistics for people with between 2015.
Potassium-ion batteries (PIBs) are attractive for grid-scale energy storage due to the abundant potassium resource and high density. The key achieving high-performance large-scale technology lies in seeking eco-efficient synthetic processes design of suitable anode materials. Herein, a spherical sponge-like carbon superstructure (NCS) assembled by 2D nanosheets is rationally efficiently designed K
A size-controllable and facile synthetic strategy has been developed to fabricate a series of hollow mesoporous silica nanoparticles (HMSNs) with tunable cores or shell thicknesses by employing gold (Au NPs) cetyltrimethylammonium bromide (CTAB) as dual templates. Various sizes Au NPs different amounts tetraethyl orthosilicate contributed structure-tailored silica-coated NPs. After calcination, CTAB molecules were completely removed, could still support the due high melting point. HMSNs...
Dihydroartemisinin (DHA) has attracted increasing attention as an anticancer agent. However, using DHA to treat cancer usually depends on the synergistic effects of exogenous components, and loss during delivery reduces its effectiveness in therapy. Reported herein is a programmed release nanoplatform synergistically with Fe-TCPP [(4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis(benzoic acid)] NMOF (nanoscale MOF) having CaCO3 mineralized coating, which prevents leakage transport bloodstream....
The development of a specific reaction nanomaterials and reactive species is fundamental importance for the determination biomolecules. Here we report novel nanoprobe detection imaging ascorbic acid (AA) in living cells vivo based on cobalt oxyhydroxide (CoOOH) AA. Persistent luminescence nanoparticles (PLNPs) were used as unit, CoOOH nanoflakes served quencher. When was modified surface PLNPs, PLNPs efficiently quenched by CoOOH. In presence AA, reduced to Co2+ restored. showed high...
Tumor hypoxia typically occurs inside a solid tumor with an inadequate oxygen supply, sharply reducing the therapeutic efficiency of radiotherapy and significantly increasing risk local recurrence.
Blocking energy metabolism of cancer cells and simultaneously stimulating the immune system to perform attack are significant for treatment. However, how potently deliver different drugs with these functions remains a challenge. Herein, we synthesized nanoprodrug formed by F127-coated drug dimer inhibit glycolysis alleviate immunosuppressive microenvironment. The was delicately constructed connect lonidamine (LND) NLG919 disulfide bond which can be cleaved excess GSH release two drugs. LND...
Abstract Formins have long been known to regulate microfilaments but also recently shown associate with microtubules. In this study, Arabidopsis thaliana FORMIN14 (AFH14), a type II formin, was found both microtubule and microfilament arrays. AFH14 expressed in BY-2 cells decorate preprophase bands, spindles, phragmoplasts induce coalignment of microtubules microfilaments. These effects perturbed the process cell division. Localization microtubule-based structures confirmed suspension cells....
A photothermal and immune co-therapy strategy based on natural melanin nanoparticles was developed for treating primary abscopal breast cancers.
Lycopene (Lyc) as a natural antioxidant has attracted widespread attention. Di(2-ethylhexyl) phthalate (DEHP) can cause serious spleen injury in animals via the environment and food chain. For investigation of whether Lyc could alleviate DEHP-exerted pyroptosis through inhibiting Caspase-1/NLRP3 pathway activation, 140 male mice were randomly divided into 7 groups: control group, vehicle group (5 mg/kg BW/day), DEHP-exposed (500 or 1000 BW/day, respectively), DEHP + groups by daily...
Abstract Islet cell replacement is considered as the optimal treatment for type I diabetes. However, availability of human pancreatic islets transplantation limited. Here, we show that bone marrow‐derived mesenchymal stem cells (hMSCs) could be induced to differentiate into functional insulin‐producing by introduction duodenal homeobox‐1 (PDX‐1). Recombinant adenoviral vector was used deliver PDX‐1 gene hMSCs. After being infected with Ad‐PDX‐1, hMSCs were successfully insulin‐secreting...
Developing efficient methods for targeting cancer cells and encapsulating drugs coupled with activated release holds enormous potential cell imaging therapy. Herein, a novel dual-targeted nanocarrier was developed on the basis of gold nanoparticles modified dense shell synthetic oligonucleotides. The folic acid functionalized single-stranded DNA designed to target folate receptor surface, molecular beacon employed as drug carrier associated intracellular tumor mRNA. Intracellular experiments...
Abstract Immunogenic cell death (ICD) is an important modulation type for stimulating anticancer immune responses and amplifying immunotherapy efficacy. When ICD occurs, endoplasmic reticulum (ER) stress plays a vital role exposing immunogens. Herein, functionalized DNA tetrahedron nanoregulator to specifically trigger ER enhancing cancer designed. The can target organelles by binding the sulfonamide receptor of cells. Then glucose depletion reactive oxygen species generation cause strong...
Reactive oxygen species (ROS)-based cancer treatments have attracted much attention in recent years. However, most patients respond poorly to the monotypic ROS during these treatments. In this work, a multiple ROS-based immunotherapy synergistic strategy has been developed enhance therapeutic effect of cancer. We prepare three-dimensional covalent organic framework (3D COF-TATB), and embed copper ions (Cu2+) into skeleton obtain multifunctional nanomaterial, 3D Cu@COF-TATB. system,...
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms pathological features COVID after Omicron BTIs remain unclear. Assessing long-term effects COVID-19 immune recovery is crucial for understanding managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents six-month with routine blood tests, proteomic analysis single-cell RNA sequencing (scRNA-seq). We found that major organs exhibited ephemeral...
A cancer therapy strategy based on nanoscale COFs and GA was developed to enhance photothermal at mild-temperature by inhibiting HSP90.