A5100338021- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Bladder and Urothelial Cancer Treatments
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Urinary and Genital Oncology Studies
- Pancreatic and Hepatic Oncology Research
- Breast Lesions and Carcinomas
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Esophageal and GI Pathology
- Ferroptosis and cancer prognosis
Qilu Hospital of Shandong University
2016-2025
Dalian Medical University
2011-2024
First Affiliated Hospital of Dalian Medical University
2011-2024
The University of Texas MD Anderson Cancer Center
2020-2024
Shanghai Jiao Tong University
2010-2024
Shanghai Sixth People's Hospital
2010-2024
Lishui University
2024
Wenzhou Medical University
2024
Capital Medical University
2021-2023
Capital University
2023
Tumor hypoxia typically occurs inside a solid tumor with an inadequate oxygen supply, sharply reducing the therapeutic efficiency of radiotherapy and significantly increasing risk local recurrence.
Despite evidence demonstrating an overall survival benefit with up-front hormone therapy in addition to established synergy between and radiation, the of metastasis-directed (MDT) for oligometastatic prostate cancer, date, has not been evaluated a randomized clinical trial.
Abstract Background The interaction between tumor cells and inflammatory has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). main aims of the study were to investigate clinical significance tumor-infiltrating neutrophils neturophil-to-CD8+ lymphocyte ratio (NLR), analyze distribution CD8+ lymphocytes ESCC treated by curative resection. Methods expressions CD66b CD8 assessed with double staining immunohistochemistry surgical specimens from 90 patients...
Abstract The cell surface protein Trop-2 is highly expressed in a wide variety of epithelial cancers. In contrast, there little or no expression adult somatic tissue. Because it that selectively tumor cells, potential therapeutic target. However, whether actively involved tumorigenesis and its targeting for treatment would be effective have not been examined. Here, we show necessary invasiveness colon cancer as both are inhibited when suppressed by RNA interference. Conversely, ectopic cells...
We developed a novel strategy for enhanced radiation therapy based on mitochondria targeted titanium dioxide-gold nanoradiosensitizer.
Non-small cell lung cancer (NSCLC), which consists mainly of adenocarcinoma (LUAD) and squamous carcinoma (LUSC), are the leading cause deaths worldwide. In this study, we performed a comprehensive analysis tumor microenvironmental genetic factors to identify prognostic biomarkers for NSCLC. We evaluated immune stromal scores patients with LUAD LUSC using data from The Cancer Genome Atlas database ESTIMATE algorithm. Based on these scores, differentially expressed genes were obtained...
MiR-21 induces neoplastic transformation, cell proliferation, and metastasis downregulates programmed death4 (PDCD4) in some cancers. The aim of this study was to investigate the roles interactions PDCD4 miR-21 human renal carcinoma (RCC).A total 32 paired tumor normal tissue specimens from RCC patients as well three cancer lines (786-O, A498, caki-1) one epithelial kidney line (HK-2) were studied. expression levels (protein mRNA) examined by Western blot analysis qRT-PCR luciferase reporter...
Background: The interaction between tumor cells and inflammatory has not been systematically investigated in esophageal squamous cell carcinoma (ESCC).The aim of the present study was to evaluate whether preoperative lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR) could predict prognosis ESCC patients undergoing esophagectomy.Materials Methods: Records from 218 with histologically diagnosed who underwent attempted curative surgery January 2007 December...
Cardiovascular and cerebrovascular diseases induced by atherosclerosis (AS) have become the dominant cause of disability mortality throughout world. The typical early pathological process AS involves activation inflammatory macrophages in vulnerable plaque. In this work, we first employed chitosan-coated carbon nanocages (CS-CNCs) as nanocarriers to load Chlorin e6 (Ce6) then linked dextran sulfate (DS) outermost layer electrostatic adsorption create a multifunctional therapeutic...
Abstract The p19ARF tumor suppressor limits ribosome biogenesis and responds to hyperproliferative signals activate the p53 checkpoint response. Although its activation of has been well characterized, role ARF in restraining nucleolar production is poorly understood. Here we report use a mass spectroscopic analysis identify protein changes within nucleoli Arf-deficient mouse cells. Through this approach, discovered that limited localization RNA helicase DDX5, which promotes synthesis...
Socioeconomic status (SES) has been focused on as a key determinant of the incidence cancer, cancer stage at diagnosis well treatment choices in western countries. However, to authors' knowledge, little work done concerning relationship SES and esophageal China.Patients diagnosed with primary from January December 2007 Qilu hospital were included. was determined by questionnaire including religion, years schooling high education, place residence, occupation, annual household income,...
Radiotherapy is an extensively used treatment modality in the clinic and can kill malignant cells by generating cytotoxic reactive oxygen species (ROS). Unfortunately, excessive dosages of radiation are typically required because only a small proportion radiative energy adsorbed soft tissues tumor, which results nonselective killing normal severe systemic side effects. An efficient nanosensitizer that makes cancer more sensitive to radiotherapy under relatively low dose would be highly...
The BSA-MnO<sub>2</sub>/IR820@OCNC nanosystem is a “one for all” system that allows highly efficacious real-time imaging-guided phototherapy of esophageal cancer.
Basal-like breast cancers (BLBC) are highly aggressive, yet selective therapies targeting the specific oncoproteins driving these tumors have not been developed. These frequently express epidermal growth factor receptor (EGFR), with resistance to its inhibition being well documented, albeit poorly understood. Notch pathway activation is also common in this cancer subtype and can be suppressed by gamma-secretase inhibitors, which effectively block cleavage activation. Herein, we show that...
Trop2, an oncogenic cell surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function biology remains relatively unexplored. To investigate the role of Trop2 carcinogenesis, we generated Trop2(-/-) mice, which are viable and possess normal lifespan. Contrary to expectations, loss fails suppress keratinocyte transformation. Instead, ras-transformed keratinocytes preferentially pass through mesenchymal transition...
A low-cost, easy-to-operate, highly sensitive and effective lung cancer diagnostic kit (LCDK) was developed, can realize non-invasive detection of early-, middle- late-stage cancers using clinical salivary urine samples.