A5082676747- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cell death mechanisms and regulation
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Urinary Bladder and Prostate Research
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Ideological and Political Education
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Renal and related cancers
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
Dalian Medical University
2014-2025
First Affiliated Hospital of Dalian Medical University
2014-2025
Zhaoqing University
2022-2023
Fifth Hospital In Wuhan
2014
Wuhan University
2014
To compare the safety and efficiency of conventional monopolar, plasmakinetic holmium laser transurethral resection bladder tumor (CM-TURBT, PK-TURBT HoL-TURBT) while managing primary non-muscle invasive cancer.From 2005 to 2009, 173 patients with cancer underwent endoscopic surgery. Among them, 51 CM-TURBT, 58 PK-TURBT, 64 HoL-TURBT. All were divided into three risk groups (low, intermediate, high) based on European Association Urology guidelines prognostic factors recurrence. Clinical...
Abstract Neddylation is a post-translational modification process, similar to ubiquitination, that controls several biological processes. Notably, it often aberrantly activated in neoplasms and plays critical role the intricate dynamics of tumor microenvironment (TME). This regulatory influence neddylation permeates extensively profoundly within TME, affecting behavior cells, immune angiogenesis, extracellular matrix. Usually, promotes progression towards increased malignancy. In this...
MiR-21 induces neoplastic transformation, cell proliferation, and metastasis downregulates programmed death4 (PDCD4) in some cancers. The aim of this study was to investigate the roles interactions PDCD4 miR-21 human renal carcinoma (RCC).A total 32 paired tumor normal tissue specimens from RCC patients as well three cancer lines (786-O, A498, caki-1) one epithelial kidney line (HK-2) were studied. expression levels (protein mRNA) examined by Western blot analysis qRT-PCR luciferase reporter...
Emerging evidence has indicated that long non‑coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) regulates cell growth, differentiation, apoptosis and cancer progression. However, expression function of HOTTIP in progression renal carcinoma (RCC) remain largely unknown. In this study, we investigated role lncRNA RCC. The levels RCC tissues lines were determined by RT‑qPCR. association between clinicopathological characteristics prognosis was analyzed patients with from TCGA...
The inhibitors of apoptosis (IAPs) are a group anti-apoptotic factors in the apoptotic pathway that render cancer cells insensitive to stimulation. Recently, several members IAP family have been investigated context bladder cancer, and some these associated with specific clinical pathological tumor features, prognosis. These data suggested expression an individual nuclear has important relationship progression cancer. To date, there no studies concerning overall tendencies IAPs their...
Background: Neddylation, a post-translational modification process, plays crucial role in various human neoplasms. However, its connection with kidney renal clear cell carcinoma (KIRC) remains under-researched. Methods: We validated the Gene Set Cancer Analysis Lite (GSCALite) platform against The Genome Atlas (TCGA) database, analyzing 33 cancer types and their link 17 neddylation-related genes. This included examining copy number variations (CNVs), single nucleotide (SNVs), mRNA...
Livin, X-linked inhibitor of apoptosis (XIAP), and Survivin are three well-known inhibitors almost exclusively over-expressed in cancer cells considered potent targets for treatment. In the present study, we found that XIAP, were simultaneously expressed bladder cells. We speculated might have synergistic effects on cell growth apoptosis. Our results confirmed combined knockdown all these genes can synergistically inhibit proliferation transformation ability high-grade T24 promote apoptotic...
Abstract BACKGROUND Prostate cancer is the third most common and second leading cause of death for males in US. Livin has recently been described as a cancer‐associated member inhibitor apoptosis proteins family, highly expressed prostate cancer. gene encodes two splicing variants, termed Livin‐α Livin‐β. We hypothesized that deregulation proliferation could be due part to expression. METHODS Pathological analysis was performed 20 tissues 5 benign prostatic hyperplasia tissues. The...